scholarly journals Abnormalities in the erythrocyte membrane in acute lymphoid leukaemia

1989 ◽  
Vol 258 (3) ◽  
pp. 903-906 ◽  
Author(s):  
M Kundu ◽  
J Basu ◽  
P Chakrabarti ◽  
M M Rakshit
Keyword(s):  
Spatial Distribution ◽  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Severe Anaemia ◽  
Lymphoid Leukaemia ◽  
Acute Lymphoid Leukaemia ◽  
First Report

Erythrocytes from patients suffering from acute lymphoid leukaemia (ALL) show decreased proportions of spectrin tetrameters and altered spatial distribution of band 4.1 and ankyrins. These abnormalities of the cytoskeleton are probably responsible for altered membrane fluidity and transbilayer distribution of phosphatidylethanolamine in ALL. ALL is associated with severe anaemia and usually, but not always, with overproduction of lymphocytes. To our knowledge, this is the first report of abnormalities in the erythrocyte membrane in ALL which may, in part, be responsible for the observed anaemia.

Erythrocyte membrane fluidity and haemoglobin haemoporphyrin conformation: features revealed in patients with heart failure

2005 ◽  
Vol 11 (4) ◽  
pp. 209-213 ◽  
Author(s):  
O.V. Rodnenkov ◽  
O.G. Luneva ◽  
N.A. Ulyanova ◽  
G.V. Maksimov ◽  
A.B. Rubin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Patients With Heart Failure ◽  
Erythrocyte Membrane Fluidity

scholarly journals A CASE OF ACUTE LYMPHOID LEUKÆMIA.

The Lancet ◽  
1918 ◽  
Vol 191 (4945) ◽  
pp. 803
Author(s):  
JohnC. Tull
Keyword(s):  
Lymphoid Leukaemia ◽  
Acute Lymphoid Leukaemia

Erythrocyte membrane fluidity and indices of plasmatic oxidative damage after acute physical exercise in humans

2010 ◽  
Vol 111 (6) ◽  
pp. 1127-1133 ◽  
Author(s):  
C. Berzosa ◽  
E. M. Gómez–Trullén ◽  
E. Piedrafita ◽  
I. Cebrián ◽  
E. Martínez–Ballarín ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Oxidative Damage ◽  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Erythrocyte Membrane Fluidity ◽  
Acute Physical Exercise ◽  
Exercise In Humans

Mechanism of increased erythrocyte membrane fluidity during magnesium deficiency in weanling rats

1989 ◽  
Vol 257 (2) ◽  
pp. C270-C276 ◽  
Author(s):  
S. Tongyai ◽  
Y. Rayssiguier ◽  
C. Motta ◽  
E. Gueux ◽  
P. Maurois ◽  
...  
Keyword(s):  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Magnesium Deficiency ◽  
Osmotic Fragility ◽  
Magnesium Content ◽  
Male Rats ◽  
Surface Irregularities ◽  
Erythrocyte Membrane Fluidity ◽  
And Control

The erythrocyte membrane was investigated in weanling male rats pair fed with magnesium-deficient and control diets for 8 days. Fluorescence polarization studies revealed a 15% increase in the fluidity of membranes from deficient rats. A similar increase in the fluidity of liposomes indicated that protein was not involved. The change was associated with decreased osmotic fragility of intact erythrocytes; the cells lost their biconcavity and had a flattened appearance with surface irregularities. Analysis of the membranes showed decreased amounts of magnesium, cholesterol, and sphingomyelin in the deficient group. The reduced ratios of cholesterol to phospholipid and sphingomyelin to phosphatidylcholine were consistent with the increased fluidity. Addition of physiological amounts of magnesium to the medium rigidified membranes incubated in tris(hydroxymethyl)-aminomethane buffer, and this was prevented by the presence of EDTA. Cross-incubation experiments with erythrocyte ghosts and plasma from the two groups of rats showed that magnesium-deficient plasma increased the fluidity of control ghosts and control plasma rigidified ghosts from magnesium-deficient rats. Addition of sufficient magnesium chloride to raise the magnesium content of deficient plasma to normal had no significant effect. These results show that the increased fluidity of the erythrocyte membrane in magnesium deficiency is due to physicochemical exchange with the plasma. Although magnesium can directly influence membrane fluidity, the change during its deficiency in vivo is mainly mediated indirectly via disturbances in lipid metabolism.

scholarly journals Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women

2010 ◽  
Vol 104 (11) ◽  
pp. 1655-1661 ◽  
Author(s):  
Ai Guo Ma ◽  
Evert G. Schouten ◽  
Yong Ye Sun ◽  
Fang Yang ◽  
Xiu Xia Han ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Ferrous Sulphate ◽  
Randomised Trial ◽  
Control Group ◽  
Placebo Control ◽  
Group I ◽  
Erythrocyte Membrane Fluidity

Pregnancy is a condition exhibiting increased susceptibility to oxidative stress, and Fe plays a central role in generating harmful oxygen species. The objective of the present study is to investigate the changes in haematological status, oxidative stress and erythrocyte membrane fluidity in anaemic pregnant women after Fe supplementation with and without combined vitamins. The study was a 2 months double-blind, randomised trial. Pregnant women (n 164) were allocated to four groups: group C was the placebo control group; group I was supplemented daily with 60 mg Fe (ferrous sulphate) daily; group IF was supplemented daily with Fe plus 400 μg folic acid; group IM was supplemented daily with Fe plus 2 mg retinol and 1 mg riboflavin, respectively. After the 2-month trial, Hb significantly increased by 15·8, 17·3 and 21·8 g/l, and ferritin by 2·8, 3·6 and 11·0 μg/l, in the I, IF and IM groups compared with placebo. Polarisation (ρ) and microviscosity (η) decreased significantly in other groups compared with placebo, indicating an increase in membrane fluidity. Significant decreases of ρ and η values compared with group C were 0·033 and 0·959 for group I, 0·037 and 1·074 for group IF and 0·064 and 1·865 for group IM, respectively. In addition, significant increases of glutathione peroxidase activities and decreases of malondialdehyde were shown in all treated groups, as well as increases of plasma retinol and urine riboflavin in group IM. The findings show that supplementation with Fe and particularly in combination with vitamins could improve the haematological status as well as oxidative stress and erythrocyte membrane fluidity.

scholarly journals Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)

2018 ◽  
Vol 55 ◽  
pp. 96-103 ◽  
Author(s):  
A. Bonaventure ◽  
L. Orsi ◽  
J. Rudant ◽  
S. Goujon-Bellec ◽  
G. Leverger ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Lymphoid Leukaemia ◽  
Acute Lymphoid Leukaemia ◽  
History Of

Erythrocyte membrane fluidity during mesoglycan treatment

1992 ◽  
Vol 12 (3) ◽  
pp. 449-453
Author(s):  
Gregorio Caimi ◽  
Stefano Romandini ◽  
Rosalia Lo Presti ◽  
Antonio Serra ◽  
Maria Montana ◽  
...  
Keyword(s):  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Erythrocyte Membrane Fluidity
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