Relationships between the Current Field Surrounding an Isolated Dog Heart and the Potential Distribution on the Surface of the Body

2015 ◽  
pp. 72-76 ◽  
Author(s):  
B. Taccardi ◽  
C. Viganotti ◽  
E. Macchi ◽  
L. De Ambroggi
Keyword(s):  
Potential Distribution ◽  
The Body ◽  
Current Field ◽  
Dog Heart ◽  
Isolated Dog Heart

scholarly journals The effect of coronary inflow pressure on coronary vascular resistance in the isolated dog heart.

1984 ◽  
Vol 54 (6) ◽  
pp. 760-772 ◽  
Author(s):  
F L Hanley ◽  
L M Messina ◽  
M T Grattan ◽  
I E Hoffman
Keyword(s):  
Vascular Resistance ◽  
Coronary Vascular Resistance ◽  
Dog Heart ◽  
Isolated Dog Heart

Metabolism of totally ischemic excised dog heart I. Construction of a computer model

1979 ◽  
Vol 237 (5) ◽  
pp. R318-R326 ◽  
Author(s):  
Murray J. Achs ◽  
David Garfinkel
Keyword(s):  
Computer Model ◽  
Metabolic Regulation ◽  
Krebs Cycle ◽  
The Body ◽  
Heavy Sedation ◽  
Dog Heart ◽  
Rat Hearts ◽  
Heart Preparation ◽  
Time Courses ◽  
Underlying Mechanisms

Construction and fit to the experimental data of a computer model of glycolysis, the Krebs cycle, and related metabolism in an ischemic dog heart preparation, involving 122 metabolites, 65 enzymes, and 406 chemical reactions, is described. The experimental preparation simulated is a dog heart excised from the body, placed in a beaker of Tyrode's solution, and sampled for 100 min; the model required only moderate modification from models representing perfused rat hearts, and little modification from a model of another ischemic dog heart preparation. Common underlying mechanisms for the ischemia are indicated, although this preparation appears to evolve more slowly with time, perhaps owing to heavy sedation and diffusion-limited transport. Lactate is, at first, exported and then accumulates intracellularly; pH falls, but not as much in the mitochondria as the cytoplasm; redox couples go reduced, but with counterintuitive time courses; calcium phosphate is calculated to precipitate, as often observed in cardiac ischemia enzymes; glycolysis; simulation; metabolic regulation Submitted on October 24, 1978 Accepted on May 21, 1979

A theory for the quantification of transcapillary exchange by tracer-dilution curves

1964 ◽  
Vol 207 (1) ◽  
pp. 162-168 ◽  
Author(s):  
Pablo Martin ◽  
David Yudilevich
Keyword(s):  
Experimental Data ◽  
Turnover Rate ◽  
Mathematical Formulation ◽  
Indicator Dilution ◽  
Capillary Barrier ◽  
Dog Heart ◽  
Tracer Dilution ◽  
Isolated Dog Heart ◽  
Fractional Turnover ◽  
Dilution Curves

A mathematical formulation of the simultaneously obtained indicator-dilution curves of two tracers: one confined to plasma and another diffusible through the capillary barrier, is made. The procedure allows the estimation for the permeable substance of the fractional extraction from the blood, and the interstitial fractional turnover rate and compartment size. The experimental data is obtained in 3–4 min in isolated perfused organs. Na22 (NaCl) and siderophilin-Fe59 first circulation dilution curves obtained in the isolated dog heart are used to exemplify the procedure.

Potassium Transfer Kinetics in the Isolated Dog Heart. Influence of Contraction Rate, Ventricular Fibrillation, High Serum Potassium and Acetylcholine

1958 ◽  
Vol 195 (2) ◽  
pp. 451-458 ◽  
Author(s):  
John C. Wood ◽  
Hadley L. Conn
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Serum Potassium ◽  
Interstitial Fluid ◽  
High Serum ◽  
Extracellular Potassium ◽  
Dog Heart ◽  
Potassium Flux ◽  
Potassium Exchange ◽  
Isolated Dog Heart

Potassium transfer kinetics were studied in the perfused isolated dog heart with the aid of radioactive tracer (K42) techniques. The effects of heart rate, ventricular fibrillation, high serum potassium and acetylcholine on cell-interstitial fluid potassium exchange were investigated. A positive linear correlation between potassium exchange and heart rate was found. Potassium transfer per beat was less than that found previously in the in vivo dog heart. A relative increase in potassium flux was noted when the heart was arrested by high serum potassium or slowed by acetylcholine. A relative decrease in calculated potassium flux accompanied ventricular fibrillation. The results suggest that potassium exchange between the myocardial cell and interstitial fluid is a function of heart rate, and that extracellular potassium concentration, acetylcholine and possibly the strength of myofibril contraction are other factors influencing exchange. The decreased exchange in ventricular fibrillation may reflect incomplete cell membrane depolarization.

Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

1972 ◽  
Vol 140 (1) ◽  
pp. 234-239 ◽  
Author(s):  
E. H. Herman ◽  
R. M. Mhatre ◽  
I. P. Lee ◽  
V. S. Waravdekar
Keyword(s):  
Dog Heart ◽  
Isolated Dog Heart

Regional tissue uptake of D2O in perfused organs: rat liver, dog heart and gastrocnemius

1959 ◽  
Vol 197 (4) ◽  
pp. 897-902 ◽  
Author(s):  
Alan M. Thompson ◽  
H. Mead Cavert ◽  
Nathan Lifson ◽  
Robert L. Evans
Keyword(s):  
Rat Liver ◽  
Tissue Concentration ◽  
Tissue Sample ◽  
Sampling Procedure ◽  
Venous Outflow ◽  
Tissue Concentrations ◽  
Dog Heart ◽  
Concentration Curves ◽  
Outflow Concentration ◽  
Isolated Dog Heart

Regional tissue D2O concentrations were measured in the isolated dog heart, dog gastrocnemius and rat liver following relatively brief perfusions with D2O-labeled fluid. Results indicate heterogeneity of tissue concentrations in all three organs. A venous outflow concentration curve for the liver was reconstructed on the assumptions that each regional tissue sample represented an equally probable portion of a composite organ and that in each region D2O transport was flow-limited. The agreement between this curve and the observed outflow curve was sufficiently good to suggest that the discrepancies between the observed venous curve and that for the theoretical case of a completely flow-limited organ can be largely explained for the liver by macroscopic regional perfusion heterogeneity without invoking microscopic tissue transport limitation. In the case of the heart and the gastrocnemius, the observed macroscopic tissue heterogeneity was insufficient to account for the discrepancies between the respective venous outflow concentration curves and the theoretical case. However, in the heart, regions of low tissue concentration were apparently systematically missed in the sampling procedure. The actual heterogeneity in both organs was probably underestimated.

Pharmacological analysis of positive chronotropic and inotropic responses to etilefrine in isolated dog heart preparations

1992 ◽  
Vol 7 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Yasuyuki Karasawa ◽  
Yasuyuki Furukawa ◽  
Makoto Murakami ◽  
Lei-Ming Ren ◽  
Shin Takayama ◽  
...  
Keyword(s):  
Dog Heart ◽  
Pharmacological Analysis ◽  
Inotropic Responses ◽  
Isolated Dog Heart
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