Pharmacological analysis of positive chronotropic and inotropic responses to etilefrine in isolated dog heart preparations

1992 ◽  
Vol 7 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Yasuyuki Karasawa ◽  
Yasuyuki Furukawa ◽  
Makoto Murakami ◽  
Lei-Ming Ren ◽  
Shin Takayama ◽  
...  
Keyword(s):  
Dog Heart ◽  
Pharmacological Analysis ◽  
Inotropic Responses ◽  
Isolated Dog Heart

Inhibition by Glibenclamide of Negative Chronotropic and Inotropic Responses to Pinacidil, Acetylcholine, and Adenosine in the Isolated Dog Heart

1992 ◽  
Vol 19 (4) ◽  
pp. 618-624 ◽  
Author(s):  
Makoto Murakami ◽  
Yasuyuki Furukawa ◽  
Yasuyuki Karasawa ◽  
Lei-Ming Ren ◽  
Shin Takayama ◽  
...  
Keyword(s):  
Dog Heart ◽  
Inotropic Responses ◽  
Isolated Dog Heart

scholarly journals The effect of coronary inflow pressure on coronary vascular resistance in the isolated dog heart.

1984 ◽  
Vol 54 (6) ◽  
pp. 760-772 ◽  
Author(s):  
F L Hanley ◽  
L M Messina ◽  
M T Grattan ◽  
I E Hoffman
Keyword(s):  
Vascular Resistance ◽  
Coronary Vascular Resistance ◽  
Dog Heart ◽  
Isolated Dog Heart

A theory for the quantification of transcapillary exchange by tracer-dilution curves

1964 ◽  
Vol 207 (1) ◽  
pp. 162-168 ◽  
Author(s):  
Pablo Martin ◽  
David Yudilevich
Keyword(s):  
Experimental Data ◽  
Turnover Rate ◽  
Mathematical Formulation ◽  
Indicator Dilution ◽  
Capillary Barrier ◽  
Dog Heart ◽  
Tracer Dilution ◽  
Isolated Dog Heart ◽  
Fractional Turnover ◽  
Dilution Curves

A mathematical formulation of the simultaneously obtained indicator-dilution curves of two tracers: one confined to plasma and another diffusible through the capillary barrier, is made. The procedure allows the estimation for the permeable substance of the fractional extraction from the blood, and the interstitial fractional turnover rate and compartment size. The experimental data is obtained in 3–4 min in isolated perfused organs. Na22 (NaCl) and siderophilin-Fe59 first circulation dilution curves obtained in the isolated dog heart are used to exemplify the procedure.

scholarly journals Pharmacological Analysis of Positive Chrono- and Inotropic Responses to Denopamine (TA-064) in Dog Cross-Circulated Atrial and Ventricular Preparations

1990 ◽  
Vol 52 (1) ◽  
pp. 69-79
Author(s):  
Kunio AKAHANE ◽  
Yasuyuki FURUKAWA ◽  
Yasuyuki KARASAWA ◽  
Lei-Ming REN ◽  
Shigetoshi CHIBA
Keyword(s):  
Pharmacological Analysis ◽  
Inotropic Responses

Potassium Transfer Kinetics in the Isolated Dog Heart. Influence of Contraction Rate, Ventricular Fibrillation, High Serum Potassium and Acetylcholine

1958 ◽  
Vol 195 (2) ◽  
pp. 451-458 ◽  
Author(s):  
John C. Wood ◽  
Hadley L. Conn
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Serum Potassium ◽  
Interstitial Fluid ◽  
High Serum ◽  
Extracellular Potassium ◽  
Dog Heart ◽  
Potassium Flux ◽  
Potassium Exchange ◽  
Isolated Dog Heart

Potassium transfer kinetics were studied in the perfused isolated dog heart with the aid of radioactive tracer (K42) techniques. The effects of heart rate, ventricular fibrillation, high serum potassium and acetylcholine on cell-interstitial fluid potassium exchange were investigated. A positive linear correlation between potassium exchange and heart rate was found. Potassium transfer per beat was less than that found previously in the in vivo dog heart. A relative increase in potassium flux was noted when the heart was arrested by high serum potassium or slowed by acetylcholine. A relative decrease in calculated potassium flux accompanied ventricular fibrillation. The results suggest that potassium exchange between the myocardial cell and interstitial fluid is a function of heart rate, and that extracellular potassium concentration, acetylcholine and possibly the strength of myofibril contraction are other factors influencing exchange. The decreased exchange in ventricular fibrillation may reflect incomplete cell membrane depolarization.

Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

1972 ◽  
Vol 140 (1) ◽  
pp. 234-239 ◽  
Author(s):  
E. H. Herman ◽  
R. M. Mhatre ◽  
I. P. Lee ◽  
V. S. Waravdekar
Keyword(s):  
Dog Heart ◽  
Isolated Dog Heart
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