The effect of theophylline alone and in combination with ouabain on the isolated dog heart

1973 ◽  
Vol 278 (1) ◽  
pp. 45-54 ◽  
Author(s):  
J. Simaan ◽  
G. Fawaz
Keyword(s):  
Dog Heart ◽  
Isolated Dog Heart

scholarly journals The effect of coronary inflow pressure on coronary vascular resistance in the isolated dog heart.

1984 ◽  
Vol 54 (6) ◽  
pp. 760-772 ◽  
Author(s):  
F L Hanley ◽  
L M Messina ◽  
M T Grattan ◽  
I E Hoffman
Keyword(s):  
Vascular Resistance ◽  
Coronary Vascular Resistance ◽  
Dog Heart ◽  
Isolated Dog Heart

A theory for the quantification of transcapillary exchange by tracer-dilution curves

1964 ◽  
Vol 207 (1) ◽  
pp. 162-168 ◽  
Author(s):  
Pablo Martin ◽  
David Yudilevich
Keyword(s):  
Experimental Data ◽  
Turnover Rate ◽  
Mathematical Formulation ◽  
Indicator Dilution ◽  
Capillary Barrier ◽  
Dog Heart ◽  
Tracer Dilution ◽  
Isolated Dog Heart ◽  
Fractional Turnover ◽  
Dilution Curves

A mathematical formulation of the simultaneously obtained indicator-dilution curves of two tracers: one confined to plasma and another diffusible through the capillary barrier, is made. The procedure allows the estimation for the permeable substance of the fractional extraction from the blood, and the interstitial fractional turnover rate and compartment size. The experimental data is obtained in 3–4 min in isolated perfused organs. Na22 (NaCl) and siderophilin-Fe59 first circulation dilution curves obtained in the isolated dog heart are used to exemplify the procedure.

Potassium Transfer Kinetics in the Isolated Dog Heart. Influence of Contraction Rate, Ventricular Fibrillation, High Serum Potassium and Acetylcholine

1958 ◽  
Vol 195 (2) ◽  
pp. 451-458 ◽  
Author(s):  
John C. Wood ◽  
Hadley L. Conn
Keyword(s):  
Heart Rate ◽  
Ventricular Fibrillation ◽  
Serum Potassium ◽  
Interstitial Fluid ◽  
High Serum ◽  
Extracellular Potassium ◽  
Dog Heart ◽  
Potassium Flux ◽  
Potassium Exchange ◽  
Isolated Dog Heart

Potassium transfer kinetics were studied in the perfused isolated dog heart with the aid of radioactive tracer (K42) techniques. The effects of heart rate, ventricular fibrillation, high serum potassium and acetylcholine on cell-interstitial fluid potassium exchange were investigated. A positive linear correlation between potassium exchange and heart rate was found. Potassium transfer per beat was less than that found previously in the in vivo dog heart. A relative increase in potassium flux was noted when the heart was arrested by high serum potassium or slowed by acetylcholine. A relative decrease in calculated potassium flux accompanied ventricular fibrillation. The results suggest that potassium exchange between the myocardial cell and interstitial fluid is a function of heart rate, and that extracellular potassium concentration, acetylcholine and possibly the strength of myofibril contraction are other factors influencing exchange. The decreased exchange in ventricular fibrillation may reflect incomplete cell membrane depolarization.

Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

1972 ◽  
Vol 140 (1) ◽  
pp. 234-239 ◽  
Author(s):  
E. H. Herman ◽  
R. M. Mhatre ◽  
I. P. Lee ◽  
V. S. Waravdekar
Keyword(s):  
Dog Heart ◽  
Isolated Dog Heart

Regional tissue uptake of D2O in perfused organs: rat liver, dog heart and gastrocnemius

1959 ◽  
Vol 197 (4) ◽  
pp. 897-902 ◽  
Author(s):  
Alan M. Thompson ◽  
H. Mead Cavert ◽  
Nathan Lifson ◽  
Robert L. Evans
Keyword(s):  
Rat Liver ◽  
Tissue Concentration ◽  
Tissue Sample ◽  
Sampling Procedure ◽  
Venous Outflow ◽  
Tissue Concentrations ◽  
Dog Heart ◽  
Concentration Curves ◽  
Outflow Concentration ◽  
Isolated Dog Heart

Regional tissue D2O concentrations were measured in the isolated dog heart, dog gastrocnemius and rat liver following relatively brief perfusions with D2O-labeled fluid. Results indicate heterogeneity of tissue concentrations in all three organs. A venous outflow concentration curve for the liver was reconstructed on the assumptions that each regional tissue sample represented an equally probable portion of a composite organ and that in each region D2O transport was flow-limited. The agreement between this curve and the observed outflow curve was sufficiently good to suggest that the discrepancies between the observed venous curve and that for the theoretical case of a completely flow-limited organ can be largely explained for the liver by macroscopic regional perfusion heterogeneity without invoking microscopic tissue transport limitation. In the case of the heart and the gastrocnemius, the observed macroscopic tissue heterogeneity was insufficient to account for the discrepancies between the respective venous outflow concentration curves and the theoretical case. However, in the heart, regions of low tissue concentration were apparently systematically missed in the sampling procedure. The actual heterogeneity in both organs was probably underestimated.

Pharmacological analysis of positive chronotropic and inotropic responses to etilefrine in isolated dog heart preparations

1992 ◽  
Vol 7 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Yasuyuki Karasawa ◽  
Yasuyuki Furukawa ◽  
Makoto Murakami ◽  
Lei-Ming Ren ◽  
Shin Takayama ◽  
...  
Keyword(s):  
Dog Heart ◽  
Pharmacological Analysis ◽  
Inotropic Responses ◽  
Isolated Dog Heart

scholarly journals Circulatory Transport of Iodoantipyrine and Water in the Isolated Dog Heart

1970 ◽  
Vol 27 (3) ◽  
pp. 461-477 ◽  
Author(s):  
TADA YIPINTSOI ◽  
JAMES B. BASSINGTHWAIGHTE
Keyword(s):  
Dog Heart ◽  
Isolated Dog Heart

Cardiac responses to VIP and VIP-ergic-cholinergic interaction in isolated dog heart preparations

1990 ◽  
Vol 187 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Yasuyuki Karasawa ◽  
Yasuyuki Furukawa ◽  
Lei-Ming Ren ◽  
Manabu Takei ◽  
Makoto Murakami ◽  
...  
Keyword(s):  
Dog Heart ◽  
Cardiac Responses ◽  
Isolated Dog Heart
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