Genetic Factors and Lithium Response in Manic-Depressive Illness

2015 ◽  
pp. 23-29 ◽  
Author(s):  
J. Mendlewicz ◽  
F. Stallone
Keyword(s):  
Genetic Factors ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Lithium Response

Lithium Accumulation in Erythrocytes of Manic-Depressive Patients: An in vivo Twin Study

1978 ◽  
Vol 133 (5) ◽  
pp. 436-444 ◽  
Author(s):  
Julien Mendlewicz ◽  
Paul Verbanck ◽  
Paul Linkowski ◽  
Jean Wilmotte
Keyword(s):  
Genetic Factors ◽  
Affective State ◽  
Lithium Ion ◽  
Depressive Illness ◽  
Manic Depression ◽  
Manic Depressive Illness ◽  
Ion Distribution ◽  
Manic Depressive ◽  
Discordant Twins

SummaryGenetic factors play an important role in drug metabolism and drug response. In order to investigate genetic variables in lithium prophylaxis and lithium distribution across the erythrocyte in manic-depression, we have examined forty-two pairs of twins monozygotic (n = 25) and dizygotic (n = 17) with manic-depression. Concordant twins as a group show better lithium prophylaxis than do discordant twins. These results are consistent with previously published family studies of affective illness suggesting a positive relationship between genetic background and success of lithium prophylaxis.Lithium distribution across the red blood cell (RBC) was assessed by estimating lithium RBC/plasma ratios. The lithium ratio's intrapair differences in both groups of twins were minimal with a high heritability index suggesting that genetic factors play a role in lithium ion distribution. A high linear correlation was found between lithium ratio and plasma lithium and there was no difference in lithium ratios according to sex, affective state and response to lithium. The distribution of lithium ratios was homogenous in the lithium responders' population but this was not the case in the non-responders, suggesting biological heterogeneity of lithium distribution in lithium failures. The implications of these results are discussed as they relate to the genetic determinates of lithium prophylaxis in manic-depressive illness.These results indicate that lithium ratios are of limited value in lithium maintenance therapy. Our lithium kinetic data, however, are consistent with the concept of a lithium extrusion mechanism from red blood cells.

GENETIC HISTORY AS A PREDICTOR OF LITHIUM RESPONSE IN MANIC-DEPRESSIVE ILLNESS

The Lancet ◽  
1972 ◽  
Vol 299 (7750) ◽  
pp. 599-600 ◽  
Author(s):  
J Mendlewicz ◽  
R.R Fieve ◽  
F Stallone ◽  
J.L Fleiss
Keyword(s):  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Genetic History ◽  
Manic Depressive ◽  
Lithium Response

Conditioning and Sensitisation in the Longitudinal Course of Affective Illness

1986 ◽  
Vol 149 (2) ◽  
pp. 191-201 ◽  
Author(s):  
Robert M. Post ◽  
David R. Rubinow ◽  
James C. Ballenger
Keyword(s):  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Conceptual Approach ◽  
Longitudinal Course ◽  
Behavioural Sensitisation ◽  
Affective Illness ◽  
Biological Variables ◽  
Manic Depressive ◽  
Progressive Course

Few biological theories of manic-depressive illness have focused on the longitudinal course of affective dysfunction and the mechanisms underlying its often recurrent and progressive course. The authors discuss two models for the development of progressive behavioural dysfunction—behavioural sensitisation and electrophysiological kindling—as they provide clues to important clinical and biological variables relevant to sensitisation in affective illness. The role of environmental context and conditioning in mediating behavioural and biochemical aspects of this sensitisation is emphasised. The sensitisation models provide a conceptual approach to previously inexplicable clinical phenomena in the longitudinal course of affective illness and may provide a bridge between psychoanalytic/psychosocial and neurobiological formulations of manic-depressive illness.

Transmission of Manic-Depressive Illness

JAMA ◽  
1973 ◽  
Vol 224 (8) ◽  
pp. 1187 ◽  
Author(s):  
Julien Mendlewicz
Keyword(s):  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive

Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene

1995 ◽  
Vol 60 (5) ◽  
pp. 434-435 ◽  
Author(s):  
Rosa Puertollano ◽  
Gillermo Visedo ◽  
Jerónimo Saiz-Ruiz ◽  
Consuelo Llinares ◽  
José Fernández-Piqueras
Keyword(s):  
Polymorphic Marker ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive
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