Brain Lipids as Related to Nutrition

2015 ◽  
pp. 83-95
Author(s):  
E. Turchetto ◽  
F. Federici ◽  
P. Borri
Keyword(s):  
Brain Lipids

scholarly journals Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3579
Author(s):  
Svetlana A. Popova ◽  
Evgenia V. Pavlova ◽  
Oksana G. Shevchenko ◽  
Irina Yu. Chukicheva ◽  
Aleksandr V. Kutchin
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
High Reactivity ◽  
Biologically Active ◽  
Brain Lipids ◽  
Wide Range ◽  
Privileged Structure ◽  
Vitro Model

The pyrazoline ring is defined as a “privileged structure” in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.

Lipidomics and cognitive dysfunction – A Narrative review

2020 ◽  
Vol 45 (2) ◽  
Author(s):  
Arpita Chakraborty ◽  
Samir Kumar Praharaj ◽  
R. V. Krishnananda Prabhu ◽  
M. Mukhyaprana Prabhu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Cognitive Dysfunction ◽  
Neurological Disorders ◽  
Brain Lipids ◽  
Complex Lipids ◽  
Functional Components ◽  
The Brain

AbstractBackgroundMore than half portion of the brain is formed by lipids. They play critical roles in maintaining the brain's structural and functional components. Any dysregulation in these brain lipids can lead to cognitive dysfunction which are associated with neurological disorders such as Alzheimer's disease, Parkinson's disease, schizophrenia, vascular dementia etc. Studies have linked lipids with cognitive impairment. But not much has been studied about the complex brain lipids which might play a pivotal role in cognitive impairment. This review aims to highlight the lipidomic profiles in patients with cognitive dysfunction.ResultsForty-five articles were reviewed. These studies show alterations in complex lipids such as sphingolipids, phospholipids, glycolipids and sterols in brain in various neurological disorders such as vascular dementia, Parkinson's and Alzheimer's disease. However, the classes of fatty acids in these lipids involved are different across studies.ConclusionsThere is a need for targeted lipidomics analysis, specifically including sphingolipids in patients with neurodegenerative disorders so as to improve diagnostics as well as management of these disorders.

Quantitative brain autoradiography of [9, 10-3H]palmitic acid incorporation into brain lipids

1990 ◽  
Vol 26 (2) ◽  
pp. 196-208 ◽  
Author(s):  
J. G. Noronha ◽  
J. M. Bell ◽  
S. I. Rapoport
Keyword(s):  
Palmitic Acid ◽  
Brain Lipids ◽  
Acid Incorporation

Brain lipids in fossilized mammoths, mammuthus primigenius

1981 ◽  
Vol 68 (1) ◽  
pp. 135-140 ◽  
Author(s):  
E.M. Kreps ◽  
N.F. Avrova ◽  
M.A. Chebotarëva ◽  
E.V. Chirkovskaya ◽  
M.V. Levitina ◽  
...  
Keyword(s):  
Mammuthus Primigenius ◽  
Brain Lipids

scholarly journals Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism

2017 ◽  
Vol 112 ◽  
pp. 308-317 ◽  
Author(s):  
Melissa McDougall ◽  
Jaewoo Choi ◽  
Kathy Magnusson ◽  
Lisa Truong ◽  
Robert Tanguay ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cognitive Function ◽  
Energy Metabolism ◽  
Adult Zebrafish ◽  
Vitamin E Deficiency ◽  
Brain Lipids

Physicochemical Properties, Volatile Compounds and Phospholipid Classes of Silver Carp Brain Lipids

2013 ◽  
Vol 90 (9) ◽  
pp. 1301-1309 ◽  
Author(s):  
Caixia Wang ◽  
Wenshui Xia ◽  
Yanshun Xu ◽  
Qixing Jang ◽  
Peipie Yu
Keyword(s):  
Physicochemical Properties ◽  
Volatile Compounds ◽  
Silver Carp ◽  
Brain Lipids ◽  
Phospholipid Classes

29 Brain Lipids in Health and Disease

Food Lipids ◽  
2017 ◽  
pp. 747-764
Author(s):  
Jessica H. Hall ◽  
John L. Harwood
Keyword(s):  
Brain Lipids ◽  
Health And Disease

scholarly journals Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Brain ◽  
2014 ◽  
Vol 137 (12) ◽  
pp. 3300-3318 ◽  
Author(s):  
Dun-Sheng Yang ◽  
Philip Stavrides ◽  
Mitsuo Saito ◽  
Asok Kumar ◽  
Jose A. Rodriguez-Navarro ◽  
...  
Keyword(s):  
Mouse Model ◽  
Brain Lipids
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