A study of tetraphenylborate transport through rat brain lipids impregnated filter-membranes

1989 ◽  
Vol 11 (4) ◽  
pp. 525-531 ◽  
Author(s):  
D. Yova ◽  
G. Boudouris
Keyword(s):  
Rat Brain ◽  
Brain Lipids

Effects of desmethylimipramine and diphenylpropene derivatives on synthesis of rat brain lipids

Life Sciences ◽  
1973 ◽  
Vol 13 (7) ◽  
pp. 875-883 ◽  
Author(s):  
Peter Johnson ◽  
Trevor J. Rising ◽  
David G. Trist
Keyword(s):  
Rat Brain ◽  
Brain Lipids

scholarly journals ERRATUM

1962 ◽  
Vol 10 (3) ◽  
pp. 369-369
Keyword(s):  
Rat Brain ◽  
The Other ◽  
Brain Lipids

In the paper "Action of Formaldehyde on Rat Brain Lipids" by Deierkauf and Heslinga in the January 1962 issue, Figures 3 and 4 on page 81 have been transposed, so that the legends each refer to the other of the two figures.

scholarly journals Lipogenesis in the brain of suckling rats. Studies on the mechanism of mitochondrial-cytosolic carbon transfer

1980 ◽  
Vol 188 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Tarun B. Patel ◽  
John B. Clark
Keyword(s):  
Rat Brain ◽  
Mitochondrial Membrane ◽  
Lipid Fraction ◽  
Co2 Production ◽  
Brain Lipid ◽  
Atp Citrate Lyase ◽  
Brain Lipids ◽  
Citrate Lyase ◽  
Carbon Transfer ◽  
The Brain

1. Studies on the incorporation of [3-14C]pyruvate and d-3-hydroxy[3-14C]butyrate into the brain lipid fraction by brain homogenates of the suckling (7-day-old) rat have been carried out. 2. Whereas approximately twice as much CO2 was evolved from pyruvate compared with 3-hydroxybutyrate metabolism, similar amounts of the radioactivity of these two precursors were incorporated into the lipid fraction. Furthermore, in both cases the incorporation into lipid was almost tripled when glucose (10mm) or NADPH (2.5mm) was added to the incubation media. 3. If 5mm-(—)-hydroxycitrate, an ATP–citrate lyase inhibitor, was added to the incubation the incorporation of carbon from pyruvate was inhibited to 39% of the control and from 3-hydroxybutyrate to 73% of the control, whereas CO2 production from both precursors was not affected. 4. The incorporation from pyruvate or 3-hydroxybutyrate into lipids was not affected by the presence of 10mm-glutamate in the medium (to encourage N-acetylaspartate production). However, incorporation from pyruvate was inhibited by 21% in the presence of 5mm-amino-oxyacetate (a transaminase inhibitor) and by 83% in the presence of both hydroxycitrate (5mm) and amino-oxyacetate. 5. Incorporation from 3-hydroxybutyrate into brain lipids was inhibited by 20% by amino-oxyacetate alone, but by 55% in the presence of both hydroxycitrate and amino-oxyacetate. 6. It is concluded that the mechanism of carbon transfer from pyruvate into lipids across the mitochondrial membrane in the suckling rat brain is mainly via citrate and N-acetylaspartate. 3-Hydroxybutyrate, in addition to using these routes, may also be incorporated via acetoacetate formation and transport to the cytosol.

High-fat diets impede the lowering effect of cyclosporine a on rat brain lipids and interact with the expression of apolipoproteins E and J

Lipids ◽  
2005 ◽  
Vol 40 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Pascale Montpied ◽  
Nicole Domingo ◽  
Michèle Senft ◽  
Henri Portugal ◽  
Pierre Petit ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cyclosporine A ◽  
High Fat ◽  
Brain Lipids ◽  
Lowering Effect ◽  
High Fat Diets ◽  
Fat Diets ◽  
Apolipoproteins E

scholarly journals Hypolipidemic Drugs Can Change the Composition of Rat Brain Lipids

2004 ◽  
Vol 204 (4) ◽  
pp. 299-308 ◽  
Author(s):  
Marek Vecka ◽  
Eva Tvrzická ◽  
Barbora Stanková ◽  
František Novák ◽  
Olga Nováková ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Lipids ◽  
Hypolipidemic Drugs

scholarly journals Regional differences in rat brain lipids during global ischemia.

Stroke ◽  
1992 ◽  
Vol 23 (7) ◽  
pp. 1000-1004 ◽  
Author(s):  
M Chavko ◽  
E M Nemoto
Keyword(s):  
Rat Brain ◽  
Regional Differences ◽  
Global Ischemia ◽  
Brain Lipids

scholarly journals Lipogenesis from ketone bodies in rat brain. Evidence for conversion of acetoacetate into acetyl-coenzyme A in the cytosol

1976 ◽  
Vol 156 (3) ◽  
pp. 603-607 ◽  
Author(s):  
M S Patel ◽  
O E Owen
Keyword(s):  
Rat Brain ◽  
Ketone Bodies ◽  
Brain Mitochondria ◽  
Atp Citrate Lyase ◽  
Acetyl Coa ◽  
Cellular Compartment ◽  
Brain Lipids ◽  
Acetyl Coenzyme A ◽  
Citrate Lyase ◽  
Old Rats

The metabolism of acetoacetate via a proposed cytosolic pathway in brain of 1-week-old rats was investigated. (-)-Hydroxycitrate, an inhibitor of ATP citrate lyase, markedly inhibited the incorporation of carbon from labelled glucose and 3-hydroxybutyrate into cerebral lipids, but had no effect on the incorporation of labelled acetate and acetoacetate into brain lipids. Similarly, n-butylmalonate and benzene-1,2,3-tricarboxylate inhibited the incorporation of labelled 3-hydroxybutyrate but not of acetoacetate into cerebral lipids. These inhibitors had no effect on the oxidation to 14CO2 of the labelled substrates used. (-)-Hydroxycitrate decreased the incorporation of 3H from 3H2O into cerebral lipids by slices metabolizing either glucose or 3-hydroxybutyrate, but not in the presence of acetoacetate. (-)-Hydroxycitrate also differentially inhibited the incorporation of [2-14C]-leucine and [U-14C]leucine into cerebral lipids. The data show that, although the acetyl moiety of acetyl-CoA generated in brain mitochondria is largely translocated as citrate from these organelles to the cytosol, a cytosolic pathway exists by which acetoacetate is converted directly into acetyl-COA in this cellular compartment.

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