Long-term Epidemiologic Studies on the Possible Role of Physical Activity and Physical Fitness in the Prevention of Premature Clinical Coronary Heart Disease1

2015 ◽  
pp. 274-300 ◽  
Author(s):  
J. Stamler ◽  
D. M. Berkson ◽  
H. A. Lindberg ◽  
I. T. Whipple ◽  
Wilda Miller ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Fitness ◽  
Epidemiologic Studies

Considering a Potential Role of Linalool as a Mood Stabilizer for Bipolar Disorder

2020 ◽  
Vol 26 (40) ◽  
pp. 5128-5133
Author(s):  
Kate Levenberg ◽  
Wade Edris ◽  
Martha Levine ◽  
Daniel R. George
Keyword(s):  
Bipolar Disorder ◽  
Treatment Options ◽  
Mood Stabilizer ◽  
Well Being ◽  
Epidemiologic Studies ◽  
Treatment Regimens ◽  
Bipolar Spectrum Disorders ◽  
Short And Long Term

Epidemiologic studies suggest that the lifetime prevalence of bipolar spectrum disorders ranges from 2.8 to 6.5 percent of the population. To decrease morbidity and mortality associated with disease progression, pharmacologic intervention is indicated for the majority of these patients. While a number of effective treatment regimens exist, many conventional medications have significant side effect profiles that adversely impact patients’ short and long-term well-being. It is thus important to continue advancing and improving therapeutic options available to patients. This paper reviews the limitations of current treatments and examines the chemical compound Linalool, an alcohol found in many plant species, that may serve as an effective mood stabilizer. While relatively little is known about Linalool and bipolar disorder, the compound has been shown to have antiepileptic, anti-inflammatory, anxiolytic, anti-depressive, and neurotrophic effects, with mechanisms that are comparable to current bipolar disorder treatment options.

Leptin Functioning in Eating Disorders

CNS Spectrums ◽  
2004 ◽  
Vol 9 (7) ◽  
pp. 523-529 ◽  
Author(s):  
Palmiero Monteleone ◽  
Antonio DiLieto ◽  
Eloisa Castaldo ◽  
Mario Maj
Keyword(s):  
Physical Activity ◽  
Eating Disorders ◽  
Body Weight ◽  
Eating Behaviors ◽  
Clinical Manifestations ◽  
Immune Functions ◽  
Abnormal Eating ◽  
The Brain

AbstractLeptin is an adipocyte-derived hormone, which is involved predominantly in the long-term regulation of body weight and energy balance by acting as a hunger suppressant signal to the brain. Leptin is also involved in the modulation of reproduction, immune function, physical activity, and some endogenous endocrine axes. Since anorexia nervosa (AN) and bulimia nervosa (BN) are characterized by abnormal eating behaviors, dysregulation of endogenous endocrine axes, alterations of reproductive and immune functions, and increased physical activity, extensive research has been carried out in the last decade in order to ascertain a role of this hormone in the pathophysiology of these syndromes. In this article, we review the available data on leptin physiology in patients with eating disorders. These data support the idea that leptin is not directly involved in the etiology of AN or BN. However, malnutrition-induced alterations in its physiology may contribute to the genesis and/or the maintenance of some clinical manifestations of AN and BN and may have an impact on the prognosis of AN.

IMMUNOLOGIC AND BIOCHEMICAL STUDIES IN INFANTS AND CHILDREN WITH SPECIAL REFERENCE TO RHEUMATIC FEVER

PEDIATRICS ◽  
1948 ◽  
Vol 2 (3) ◽  
pp. 239-241
Author(s):  
MAY G. WILSON
Keyword(s):  
Rheumatic Fever ◽  
Epidemiologic Studies ◽  
Direct Result ◽  
Endogenous Factors ◽  
Number Of Children ◽  
Exogenous Agents ◽  
Exogenous Factors ◽  
Long Term Observation

CERTAIN individuals are more susceptible than others to many conditions. In recent years it has become clear that in rheumatic fever, susceptibility of the host is an important factor in the pathogenesis of the disease. It was concluded from genetic and epidemiologic studies that susceptibility to rheumatic fever is on a genetic and age basis. Although the susceptible child cannot be identified at the present time, the number of children expected to be susceptible in a group of families of known genotype may be determined on the basis of recessive inheritance. It may, therefore, be postulated that distributed among a group of families of known hereditary background are children who are susceptible and insusceptible to the acquisition of rheumatic fever. As a direct result of long term observation of rheumatic families over a period of 30 years, a second generation of children of known hereditary background is available to us for exploratory studies. This group includes children from families in which one or both parents are rheumatic, or in which neither parent is rheumatic. In this group there are normal (insusceptible), susceptible and rheumatic children. The nature of the hereditable factors which may be responsible for susceptibility is obscure. Recent advances in biochemical genetics have provocative implications in rheumatic fever. Of particular interest are the observations which demonstrate that such biochemical reactions as enzyme and protein specificities are gene determined. As a working hypothesis it seemed reasonable to postulate that in a susceptible child, abnormal physiologic, chemical, immunologic or hormonal responses might be found. Differences might then be observed in certain reactions between the normal group and a group containing a high proportion of genetically susceptible children. This approach does not conflict with the concept that exogenous factors, irrespective of their nature, may also be operative. If the nature of the endogenous factors were known, the role of possible exogenous agents would be clarified.

Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention

Gerontology ◽  
2018 ◽  
Vol 65 (3) ◽  
pp. 229-239 ◽  
Author(s):  
Haritz Arrieta ◽  
Gotzone Hervás ◽  
Chloe Rezola-Pardo ◽  
Fátima Ruiz-Litago ◽  
Miren Iturburu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Nursing Home ◽  
Physical Fitness ◽  
Physical Activity Level ◽  
Exercise Intervention ◽  
Nursing Home Residents ◽  
Exercise Program ◽  
Activity Level

Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels. Methods: We obtained study data on 112 participants from long-term nursing homes. Participants were randomly assigned to a control or an intervention group and performed a 6-month multicomponent exercise program. Serum myostatin levels were analyzed by ELISA. Assessments also included body composition (anthropometry and bioelectrical impedance), physical fitness (Senior Fitness Test), physical activity level (accelerometry), and frailty (Fried frailty criteria, Clinical Frailty Scale, and Tilburg frailty indicator). Results: The concentration of myostatin at baseline was positively correlated with: a leaner body composition (p < 0.05), and a higher number of steps per day and light and moderate-vigorous physical activity in women (p < 0.005); greater upper and lower limb strength, endurance, and poorer flexibility (p < 0.05) in men; and better performance (less time) in the 8-ft timed up-and-go test in both women (p < 0.01) and men (p < 0.005). We observed higher concentrations of serum myostatin in non-frail than in frail participants (p < 0.05). Additionally, we found that the implemented physical exercise intervention, which was effective to improve physical fitness, increased myostatin concentration in men (p < 0.05) but not in women. The improvements in physical condition were related with increases in serum myostatin only in men (p < 0.05–0.01). Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.

scholarly journals Long-Term and Transfer Effects of an Action Control Intervention in Overweight Couples: A Randomized Controlled Trial Using Text Messages

2021 ◽  
Vol 12 ◽  
Author(s):  
Corina Berli ◽  
Urte Scholz
Keyword(s):  
Physical Activity ◽  
Physical Fitness ◽  
Text Messaging ◽  
Vigorous Physical Activity ◽  
Action Control ◽  
Text Messages ◽  
Control Group ◽  
Transfer Effects ◽  
Control Intervention

Keeping a physically active lifestyle requires consistent self-regulatory effort such as action control (e.g., continuously monitoring and evaluating a behavior in terms of one’s goals). Involving the romantic partner in interventions might be particularly effective in the long run. The present study examined the long-term and transfer effects of an action control intervention in couples using text messaging for promoting target persons’ and partners’ physical activity, anthropometric measures and physical fitness 6 months post baseline. A total of 121 overweight and obese romantic couples, randomly allocated to an intervention (n = 60; information + action control text messages) or a control group (n = 61; information only) and to participating as target person or partner, completed baseline assessments (T1). 100 couples (82.6%) completed the 6-month follow-up (T3) assessment. Primary outcomes included self-reported moderate-to-vigorous physical activity (MVPA) and objective MVPA and MVPA adherence using triaxial accelerometers across a diary period of 14 days after T3. Secondary outcomes included BMI, waist-to-hip circumference and physical fitness (target persons only) using a submaximal aerobic cycle test. At T3, there were no significant between-group differences between target persons and partners with regard to their objective MVPA, self-reported MVPA, BMI, waist-hip ratio or physical fitness. No significant changes in outcomes were observed from T1 to T3; however, changes in BMI from T1 to T3 between target persons and partners in the intervention group were associated. Overall, the brief 14-days action control intervention was not effective in improving target person’s physical activity, body measures and physical fitness in the long-term. Moreover, no long-term benefits for partners emerged. While brief ecological momentary interventions might be a promising tool for short-term effects, future studies are needed to test features enhancing long-term effectiveness. Associations in romantic partners’ changes suggest that dyadic interventions can be a promising approach, as changes induced in one partner may then transfer over to the other (controlled-trials.com ISRCTN15705531).

scholarly journals Untapped Resources: 10- to 13-Year-Old Primary Schoolchildren’s Views on Additional Physical Activity in the School Setting: A Focus Group Study

2018 ◽  
Vol 15 (12) ◽  
pp. 2713 ◽  
Author(s):  
Vera van den Berg ◽  
Eline Vos ◽  
Renate de Groot ◽  
Amika Singh ◽  
Mai Chinapaw
Keyword(s):  
Physical Activity ◽  
School Setting ◽  
Field Trips ◽  
Focus Group Study ◽  
Physically Active ◽  
School Based ◽  
Teachers And Students ◽  
School Day

Schools are considered ideal venues to promote physical activity (PA) in children. However, a knowledge gap exists on how to adequately integrate PA into the school day and in particular, on the preferences of children regarding additional PA in school. Therefore, the aim of our qualitative study was to gain comprehensive insight into 10–13-year-old primary schoolchildren’s perspectives on how to increase PA in the school setting. We conducted nine focus groups (32 girls and 20 boys) with children attending the final two grades of primary school in the Netherlands. We used inductive thematic analysis to analyze the data. The results showed that children were enthusiastic about additional PA in school. Children suggested various ways to increase PA, including more time for PA in the existing curriculum, e.g., physical education (PE), recess, and occasional activities, such as field trips or sports days; school playground adaptation; improving the content of PE; and implementing short PA breaks and physically active academic lessons. Children emphasized variation and being given a voice in their PA participation as a prerequisite to keep PA enjoyable and interesting in the long term. Finally, children mentioned the role of the teacher and making efforts to accommodate all children and their different preferences as important. Children have concrete ideas, acknowledging the challenges that accompany integrating additional PA in school. We therefore recommend actively involving children in efforts to increase school-based PA and to make “additional PA in school” a shared project of teachers and students.

The role of childhood physical fitness on physical activity in mid-adulthood: A longitudinal study

2014 ◽  
Vol 29 ◽  
pp. S38
Author(s):  
A.D.G. Baxter-Jones ◽  
D. Hillis ◽  
S.A. Jackowski ◽  
J.D. Bailey ◽  
J.C. Eisenmann ◽  
...  
Keyword(s):  
Physical Activity ◽  
Longitudinal Study ◽  
Physical Fitness

scholarly journals The role of the teacher in the implementation of a School-based intervention on the physical activity practice of children

2019 ◽  
Author(s):  
Tegwen Gadais ◽  
Theo Caron ◽  
Marie Belle Ayoub ◽  
Antony Karelis ◽  
Luc Nadeau
Keyword(s):  
Physical Activity ◽  
Elementary School Teachers ◽  
Intervention Group ◽  
Training Session ◽  
Control Group ◽  
Successful Implementation ◽  
School Teachers ◽  
School Based

INTRODUCTION: Medium or long term intervention strategies on physical activity practice (PAP) need to be more effective in their implementation by practitioners. The aim of this study was to evaluate the role of a teacher to implement the Team Pentathlon (TP) in order to improve the PAP in children. METHODS: 203 children (age: 10-13years), grades 5 and 6 (intervention group [IG] N = 104, control group [CG] N = 99) were guided to increase their PAP during an 8-week period by 5 elementary school teachers (physical education or classroom) who received 4 training sessions. Levels of PAP (self-reported) were compared between groups (IG/CG), sex, socioeconomic status of the schools and between teachers: baseline and during TP. RESULTS: Several teachers noted significant increases in PAP in the IG for both boys and girls (p&lt;.05 or p&lt;.01), whereas others found only small improvements in PAP. One teacher even observed higher PAP in the CG. Training session records revealed that the teacher himself, how the TP is implemented, and proper resources were the 3 elements that explained the successful implementation of the TP program. CONCLUSION: The implementation of the TP significantly increased the PAP in children. Training sessions helped teachers to implement the TP program but personal engagement, motivation, respecting protocol and adequate environment are necessary in improving the PAP of children.

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