Mini-Laparoscopy Guided Liver Biopsy Increases Diagnostic Accuracy in Acute Liver Failure

Digestion ◽  
2014 ◽  
Vol 90 (4) ◽  
pp. 240-247 ◽  
Author(s):  
Alexander Dechêne ◽  
Jan-Peter Sowa ◽  
Martin Schlattjan ◽  
Alexander Wree ◽  
Sandra Blomeyer ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Diagnostic Accuracy ◽  
Liver Failure ◽  
Acute Liver Failure

Liver Biopsy Can Be Safely Performed in Pediatric Acute Liver Failure to Aid in Diagnosis and Management

2018 ◽  
Vol 67 (4) ◽  
pp. 441-445 ◽  
Author(s):  
Catherine A. Chapin ◽  
Saeed Mohammad ◽  
Lee M. Bass ◽  
Sarah A. Taylor ◽  
Susan Kelly ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Diagnosis And Management ◽  
Pediatric Acute Liver Failure

scholarly journals Diffuse Liver Metastasis of Small-Cell Lung Cancer Presenting as Acute Liver Failure and Diagnosed by Transjugular Liver Biopsy: A Rare Case in Whom Nodular Lesions Were Detected by Enhanced CT Examination

2015 ◽  
Vol 9 (1) ◽  
pp. 81-87 ◽  
Author(s):  
S. Mishima ◽  
Y. Nozaki ◽  
S. Mikami ◽  
E. Kihira ◽  
M. Iikura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Liver Metastasis ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Liver Metastases ◽  
Small Cell ◽  
Small Cell Lung ◽  
Enhanced Ct ◽  
Nodular Lesions

Small-cell lung cancer (SCLC) is a subgroup of lung cancer with a high frequency of liver metastasis, which is a predictor of poor prognosis. Diffuse liver metastases of SCLC with no visible nodular lesions in the liver when examined using computed tomography (CT) are relatively rare; however, a few cases with rapid progression to acute liver failure that were diagnosed after death have been reported. In this paper, we report a 63-year-old man with diffuse liver metastases of SCLC that were histologically diagnosed using a transjugular liver biopsy while the patient was alive, even though no lesions were visible during a contrast-enhanced CT examination.

scholarly journals Liver biopsy and prognosis in acute liver failure

Gut ◽  
1973 ◽  
Vol 14 (12) ◽  
pp. 927-933 ◽  
Author(s):  
J. Scotto ◽  
P. Opolon ◽  
J. Eteve ◽  
D. Vergoz ◽  
M. Thomas ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure

Contribution of Transjugular Liver Biopsy in Patients with the Clinical Presentation of Acute Liver Failure

2006 ◽  
Vol 29 (6) ◽  
pp. 1008-1010 ◽  
Author(s):  
Roberto Miraglia ◽  
Angelo Luca ◽  
Salvatore Gruttadauria ◽  
Marta Ida Minervini ◽  
Giovanni Vizzini ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Presentation ◽  
Transjugular Liver Biopsy

scholarly journals Acute liver failure due to visceral leishmaniasis in Barcelona: a case report

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Iratxe Martinez de Narvajas ◽  
Alba Díaz ◽  
Octavio Bassegoda ◽  
Adriá Carpio ◽  
Carla Fuster ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Unknown Origin ◽  
Human Migration ◽  
Negative Results ◽  
Biopsy Specimens ◽  
Inflammatory Pattern

Abstract Background Leishmaniasis is an emerging infectious disease. Due to human migration and tourism, visceral leishmaniasis may become more common in non-endemic areas. In the Mediterranean basin, visceral leishmaniasis typically occurs in rural regions. Case presentation We present an unusual urban case of acute liver failure due to visceral leishmaniasis, following a prolonged fever of unknown origin. After obtaining negative results from the bone marrow aspirate, we performed a liver biopsy that elucidated the diagnosis. The liver involvement in visceral leishmaniasis may appear as chronic granulomatous hepatitis. However diffuse hepatitis process, a necro-inflammatory pattern, without forming granulomas were observed in the liver biopsy specimens in this case. Intracytoplasmic Leishmania amastigotes were observed in the liver biopsy specimens and a polymerase chain reaction confirmed the diagnosis. Only five pathological confirmed cases of acute hepatitis due to visceral leishmaniasis have been described so far, just two in adults and both from Barcelona. A revision of the literature is performed. Conclusions Acute hepatitis is an uncommon debut of visceral leishmaniasis in immunocompetent patients. Furthermore there are only few cases in the literature that describe the histopathological changes that we found in this patient. In conclusion, in case of acute hepatitis leading to liver failure, leishmaniasis should be considered a differential diagnosis (even in non-endemic countries and without clear epidemiological exposure) and liver biopsy can elucidate the diagnosis.

scholarly journals Acute liver failure secondary to chronic lymphocytic leukemia

2019 ◽  
Vol 6 (3) ◽  
pp. 963
Author(s):  
Rohin Saini ◽  
Arvind Mishra ◽  
Kamlesh Gupta ◽  
Rohit Anand ◽  
Umesh Tripathi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chronic Lymphocytic Leukemia ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Lymphocytic Leukemia ◽  
History Of

Chronic lymphocytic leukemia is an indolent malignancy of lymphocytes commonly seen in elderly. Dissemination of malignancy is a rare cause of acute liver failure and has rarely been reported. Here we describe the case of a sixty five year old male presenting with acute liver failure. He is a diabetic with no known history of seropositive hepatits or addiction. Bone marrow and liver biopsy suggestive of chronic lymphocytic leukemia. He eventually succumbed to his illness.

scholarly journals Metastatic Breast Cancer Presenting as Acute Liver Failure

2020 ◽  
pp. 1-3
Author(s):  
Dina Halegoua-DeMarzio ◽  
Cristina Calogero ◽  
Sanaa Arastu ◽  
Dina Halegoua-DeMarzio
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Metastatic Breast ◽  
Abdominal Ultrasound ◽  
Metastatic Carcinoma ◽  
Clinical Syndrome ◽  
Unknown Etiology

Acute liver failure (ALF) is a rare clinical syndrome, with up to 20% of cases having no known etiology. Of the many causes, initial presentation of metastatic carcinoma is rare, with malignant infiltration of the liver usually diagnosed postmortem. We present a case of fulminant liver failure caused by a new diagnosis of metastatic breast cancer. A 55-year-old female with no significant medical history presented with fatigue and jaundice for one month and one week of pruritus and lower extremity edema. On presentation, she had a MELD-Na of 38 with confusion, therefore prompting rapid liver transplant evaluation. An abdominal ultrasound revealed cirrhotic morphology of the liver, ascites, and marked hepatic echogenicity. An abdominal MRI needed for listing revealed an enlarged liver that was replaced by innumerable ringenhancing lesions concerning for metastasis. A liver biopsy was performed and revealed metastatic carcinoma consistent with breast primary with no underlying cirrhosis. Transplant workup was terminated, and the patient was referred to Oncology and Palliative Care for further management. We report a clinical lesson regarding the importance of confirming prior liver disease prior to transplant listing. Rare presentations such as this argue towards liver biopsy prior to listing ALF patients of unknown etiology.

scholarly journals Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ahmed I. Edhi ◽  
Seifeldin Hakim ◽  
Christienne Shams ◽  
Damanpreet Bedi ◽  
Mitual Amin ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hemorrhagic Shock ◽  
Severe Heart Failure ◽  
Current Case ◽  
Diffuse Abdominal Pain ◽  
Shock Liver ◽  
Extensive Evaluation ◽  
Upper Gastrointestinal

While erythromycin has caused numerous cases of acute liver failure (ALF), clarithromycin, a similar macrolide antibiotic, has caused only six reported cases of ALF. A new case of clarithromycin-associated ALF is reported with hepatic histopathology and exclusion of other etiologies by extensive workup, and the syndrome of clarithromycin-associated ALF is better characterized by systematic review. A 60-year-old nonalcoholic man, with normal baseline liver function tests, was admitted with diffuse abdominal pain and AST = 499 U/L and ALT = 539 U/L, six days after completing a 7-day course of clarithromycin 500 mg twice daily for suspected upper respiratory infection. AST and ALT each rose to about 1,000 U/L on day-2 of admission, and rose to ≥6,000 U/L on day-3, with development of severe hepatic encephalopathy and severe coagulopathy. Planned liver biopsy was cancelled due to coagulopathies. Extensive evaluation for infectious, immunologic, and metabolic causes of liver disease was negative. Abdominal computerized tomography and abdominal ultrasound with Doppler were unremarkable. The patient developed massive, acute upper gastrointestinal bleeding associated with coagulopathies. Esophagogastroduodenoscopy was planned after massive blood product transfusions, but the patient rapidly expired from hemorrhagic shock. Autopsy revealed a golden-brown heavy liver with massive hepatic necrosis and sinusoidal congestion. Rise of AST/ALT to about 1,000 U/L each was temporally incompatible with shock liver because this rise preceded the hemorrhagic shock, but the subsequent AST/ALT rise to ≥6,000 U/L each may have had a component of shock liver. The six previously reported cases were limited by failure to exclude hepatitis E (4), lack of liver biopsy (2), and uninterpretable liver biopsy (1) and by confounding potential etiologies including disulfiram, israpidine, or recent acetaminophen use (3), clarithromycin overdose (1), active alcohol use (1), and severe heart failure (1). Review of 6 previously reported and current case of clarithromycin-associated ALF revealed that patients had AST and ALT values in the thousands. Five patients died and 2 survived.

scholarly journals Acute Liver Failure Associated with Levetiracetam and Lacosamide Combination Treatment for Unspecified Epileptic Disorder

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ylse Gutiérrez-Grobe ◽  
Jose Antonio Bahena-Gonzalez ◽  
Magali Herrera-Gomar ◽  
Pedro Mendoza-Diaz ◽  
Sandra García-López ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Liver Enzymes ◽  
Acute Liver Injury ◽  
Adjunctive Treatment ◽  
Drug Induced ◽  
Epileptic Disorder ◽  
Secondary Generalization

Background and Aim. Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes.Methods. We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy.Results. Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis.Conclusions. This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.

scholarly journals Clinical Relevance of Transjugular Liver Biopsy in Comparison with Percutaneous and Laparoscopic Liver Biopsy

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Max G. Beckmann ◽  
Matthias J. Bahr ◽  
Johannes Hadem ◽  
Martin Bredt ◽  
Heiner Wedemeyer ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Relevance ◽  
Clinical Decision ◽  
Hepatocellular Necrosis ◽  
Transjugular Liver Biopsy ◽  
Risk Patients ◽  
Liver Biopsies ◽  
The Impact

Background. Transjugular liver biopsy (TJLB) is frequently used to obtain liver specimens in high-risk patients. However, TJLB sample size possibly limits their clinical relevance.Methods. 102 patients that underwent TJLB were included. Clinical parameters and outcome of TJLB were analyzed. Control samples consisted of 112 minilaparoscopic liver biopsies (mLLBs) and 100 percutaneous liver biopsies (PLBs).Results. Fewer portal tracts were detected in TJLB (4.3±0.3) in comparison with PLB (11.7±0.5) and mLLB (11.0±0.6). No difference regarding the specification of indeterminate liver disease and staging/grading of chronic hepatitis was observed. In acute liver failure (n=32), a proportion of hepatocellular necrosis beyond 25% was associated with a higher rate of death or liver transplantation.Conclusions. Despite smaller biopsy samples the impact on the clinical decision process was found to be comparable to PLB and mLLB. TJLB represents a helpful tool to determine hepatocellular necrosis rates in patients with acute liver failure.

Sign in / Sign up

Export Citation Format

Share Document