Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

Chemotherapy ◽  
2014 ◽  
Vol 60 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Ummugul Uyeturk ◽  
Ugur Uyeturk ◽  
Tulin Firat ◽  
Ayhan Cetinkaya ◽  
Buket Kin Tekce ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Protective Effects ◽  
Testicular Damage

scholarly journals Protective effects of rosmarinic acid on sepsis-induced DNA damage in the liver of Wistar albino rats

2015 ◽  
Vol 6 ◽  
Author(s):  
Goktas Hatice ◽  
Bacanli Merve ◽  
Aydin Sevtap ◽  
Taner Gokce ◽  
Sahin Tolga ◽  
...  
Keyword(s):  
Dna Damage ◽  
Rosmarinic Acid ◽  
Albino Rats ◽  
Protective Effects ◽  
Wistar Albino Rats

scholarly journals Lophira lanceolata protects testicular and spermatological damages induced by cisplatin in male Wistar rats

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Solomon Tsekohol Agu ◽  
Christian Okechukwu Ezihe ◽  
Paul Friday Itodo ◽  
Hyacinth Adakole Abu
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Antineoplastic Agent ◽  
The Body ◽  
Sperm Parameters ◽  
Protective Effects ◽  
Testicular Damage ◽  
Stress Injury ◽  
Male Wistar Rats ◽  
Lophira Lanceolata

Abstracts Background Chemotherapy is associated with male infertility. Cisplatin (CP), an antineoplastic agent has been successfully used for the treatment of diverse kinds of malignancies, however, the use of this effective agent could induce oxidative stress injury, nephrotoxicity, hepatotoxicity, and testicular damage. Combined CP chemotherapy with plant extracts can diminish the toxicity and enhance the antitumor efficacy of the drug. The objective of the study was to determine the protective effect Lophira lanceolata leaf extract (LLLE) on CP-induced toxicity on male reproductive organs. Methods The study was carried out with 30 (n = 30) male Wistar rats (Rattus norvegicus). The rats were randomly assigned into 6 groups of 5 rats each. Rats in group 1 (Control) were administered distilled water per os. Rats in group 2 were administered 5 mg/kg of CP intraperitoneally (i.p). Rats in groups 3 and 4 were administered per os LLLE at the doses of 200 and 400 mg/kg body weight and rats in groups 5 and 6 were administered 5 mg/kg body weight of CP + LLLE at the doses of 200 and 400 mg/kg body weight respectively. Results The results showed a significant decrease in the sperm parameters in the group treated with CP alone when compared with the control and there in the sperm parameters in the groups administered CP + LLLE. The body and organ weights of the rats were significantly (p < 0.05) decreased in the CP treated group relative to the control. However, there was an increase in the weight of the organs in the LLLE pretreated groups. The photomicrographs showed degenerative changes in the testicular tissues of the rats administered CP alone whereas the group pretreated with the LLLE showed amelioration induced by the CP. Our study revealed that CP treatment has deleterious effects on sperm parameters and testicular tissues and the accessory sex organs (Epididymis, prostate, seminal vesicles) of the rats. Oral administration of LLLE at 200 and 400 mg/kg bodyweight for 26 days conferred protective effects against testicular damage induced by CP. Conclusion This study revealed that pretreatment with LLLE protected against CP-induced testicular toxicity.

Protective effects of mirtazapine and chrysin on experimentally induced testicular damage in rats

2017 ◽  
Vol 95 ◽  
pp. 1059-1066 ◽  
Author(s):  
Alaa E. El-Sisi ◽  
Magda E. El-Sayad ◽  
Nermine M. Abdelsalam
Keyword(s):  
Protective Effects ◽  
Testicular Damage ◽  
Experimentally Induced

scholarly journals Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 451 ◽  
Author(s):  
Azahara Rodríguez-Luna ◽  
Javier Ávila-Román ◽  
Helena Oliveira ◽  
Virginia Motilva ◽  
Elena Talero
Keyword(s):  
Natural Products ◽  
Rosmarinic Acid ◽  
Antioxidant Activities ◽  
Skin Inflammation ◽  
Protective Effects ◽  
Hacat Keratinocytes ◽  
Antioxidant Genes ◽  
Genes Expression ◽  
Anti Inflammatory ◽  
Induced Apoptosis

Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense, strategies for its prevention are currently being evaluated. Natural products such as carotenoids or polyphenols, which are abundant in the marine environment, have been used in the prevention of oxidative stress due to their demonstrated antioxidant activities. Nevertheless, the anti-inflammatory activity and its implication in photo-prevention have not been extensively studied. Thus, we aimed to evaluate the combination of fucoxanthin (FX) and rosmarinic acid (RA) on cell viability, apoptosis induction, inflammasome regulation, and anti-oxidative response activation in UVB-irradiated HaCaT keratinocytes. We demonstrated for the first time that the combination of FX and RA (5 µM RA plus 5 μM FX, designated as M2) improved antioxidant and anti-inflammatory profiles in comparison to compounds assayed individually, by reducing UVB-induced apoptosis and the consequent ROS production. Furthermore, the M2 combination modulated the inflammatory response through down-regulation of inflammasome components such as NLRP3, ASC, and Caspase-1, and the interleukin (IL)-1β production. In addition, Nrf2 and HO-1 antioxidant genes expression increased in UVB-exposed HaCaT cells pre-treated with M2. These results suggest that this combination of natural products exerts photo-protective effects by down-regulating NRLP3-inflammasome and increasing Nrf2 signalling pathway.

scholarly journals MP60-12 PROTECTIVE EFFECTS OF KOREAN RED GINSENG AGAINST SUB-ACUTE IMMOBILIZATION STRESS-INDUCED TESTICULAR DAMAGE IN EXPERIMENTAL RATS

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Kyung Hwa Choi ◽  
Sang-Ho Lee ◽  
Kyu-Min Cha ◽  
Seock-Yeon Hwang ◽  
Un-Kyu Park ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Protective Effects ◽  
Red Ginseng ◽  
Testicular Damage ◽  
Korean Red Ginseng

Taurine and pioglitazone attenuate diabetes-induced testicular damage by abrogation of oxidative stress and up-regulation of the pituitary–gonadal axis

2016 ◽  
Vol 94 (6) ◽  
pp. 651-661 ◽  
Author(s):  
Sanaa M. Abd El-Twab ◽  
Hanaa M. Mohamed ◽  
Ayman M. Mahmoud
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Inflammatory Cytokines ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Testicular Damage ◽  
Chronic Hyperglycemia ◽  
Gene And Protein Expression ◽  
Pro Inflammatory Cytokines

Chronic hyperglycemia is associated with impairment of testicular function. The current study aimed to investigate the protective effects and the possible mechanisms of taurine and pioglitazone against diabetes-induced testicular dysfunction in rats. Diabetes was induced by streptozotocin injection. Both normal and diabetic rats received taurine (100 mg/kg) or pioglitazone (10 mg/kg) orally and daily for 6 weeks. Diabetic rats showed a significant (P < 0.001) increase in glycosylated hemoglobin, glucose, homeostasis model of insulin resistance, and pro-inflammatory cytokines. Serum insulin, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were significantly (P < 0.001) decreased in diabetic rats. Taurine and pioglitazone alleviated hyperglycemia, decreased pro-inflammatory cytokines, and increased circulating levels of insulin, testosterone, LH, and FSH. Gene and protein expression of LH and FSH receptors and cytochrome P450 17α-hydroxylase (CYP17) was significantly (P < 0.001) down-regulated in testes of diabetic rats, an effect which was significantly increased after administration of taurine and pioglitazone. In addition, taurine and pioglitazone significantly decreased lipid peroxidation and DNA damage, and enhanced activity of the antioxidant enzymes in testes of diabetic rats. In conclusion, taurine and pioglitazone exerted protective effects against diabetes-induced testicular damage through attenuation of hyperglycemia, inflammation, oxidative stress and DNA damage, and up-regulation of the pituitary/gonadal axis.

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