Role of Inflammation in Diabetic Macular Edema

2014 ◽  
Vol 232 (3) ◽  
pp. 127-135 ◽  
Author(s):  
Hidetaka Noma ◽  
Tatsuya Mimura ◽  
Kanako Yasuda ◽  
Masahiko Shimura
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema

Surgical Therapy in Diabetic Macular Edema and Diabetic Intravitreal Hemorrhage

2018 ◽  
pp. 194-201
Keyword(s):  
Risk Factors ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Surgical Therapy ◽  
Current Literature ◽  
Preventive Measures ◽  
Timing Of Surgery ◽  
Intravitreal Injections ◽  
Complications Of Diabetes

Diabetic macular edema and diabetic intravitreal hemorrhage are frequent complications of diabetes. In selected cases of diabetic macular edema which is primarily treated with intravitreal injections, surgery may be performed. In this review, the role of surgery in diabetic macular edema will be discussed in light of the current literature. Moreover, changes in the timing of surgery in diabetic intravitreal hemorrhage since DRVS and risk factors and the efficacy of preventive measures for post vitrectomy intravitreal hemorrhage will be discussed.

Evolving Role of Regional Depot Corticosteroids in Management of Diabetic Macular Edema

Retina ◽  
2017 ◽  
Vol 37 (12) ◽  
pp. 2201-2207
Author(s):  
Stephen J. Kim ◽  
Ingrid U. Scott
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema

The current role of steroids in diabetic macular edema

2020 ◽  
Vol 15 (1) ◽  
pp. 11-26
Author(s):  
Maria Vittoria Cicinelli ◽  
Michele Cavalleri ◽  
Rosangela Lattanzio ◽  
Francesco Bandello
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Current Role

Dexamethasone Intravitreal Implant at the Time of Cataract Surgery in Eyes with Diabetic Macular Edema

2016 ◽  
Vol 27 (4) ◽  
pp. 433-437 ◽  
Author(s):  
Giacomo A. Panozzo ◽  
Elena Gusson ◽  
Giorgio Panozzo ◽  
Giulia Dalla Mura
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Foveal Thickness ◽  
Dexamethasone Intravitreal Implant ◽  
Positive Effects ◽  
Intravitreal Implant ◽  
A Prospective Study

Purpose To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification. Methods This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16.7 letters. Mean foveal thickness (FT) was 451 μm. The DME was naive in 11 eyes and refractory in 8 eyes. All eyes underwent a standard phacoemulsification and intraocular lens implantation; DEX-I was injected at the end of surgery. Follow-up was performed at 1 week and then monthly until DME recurrence (up to 8 months). Results At 1 week, mean VA improved by 15 letters (range 0-29 letters) and mean FT decreased by 147 μm (range 69-236 μm). Improvement consolidated at month 1, with a mean VA improvement of 18 letters (range 3-32 letters) and a mean improvement in FT of 193 μm (range 76-304 μm), remaining stable at month 2 after surgery in all eyes. The DME recurred in 1 eye at month 3, in 14 eyes (73.8%) between months 4 and 5, and after month 6 in 4 eyes (21%). Refractory DMEs demonstrated the same benefit but recurred earlier than naive ones (4 months versus 5.8 months, p<0.01). Conclusions Intraoperative DEX-I prevents DME worsening after phacoemulsification. Its positive effects last for at least 3 months.

scholarly journals The Role of Inflammation in the Pathogenesis of Macular Edema Secondary to Retinal Vascular Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Francisco J. Ascaso ◽  
Valentín Huerva ◽  
Andrzej Grzybowski
Keyword(s):  
Macular Edema ◽  
Adhesion Molecules ◽  
Retinal Vein Occlusion ◽  
Diabetic Macular Edema ◽  
Inflammatory Mediators ◽  
Vascular Diseases ◽  
Vein Occlusion ◽  
Inflammatory Processes ◽  
Nonspecific Sign

Macular edema (ME) is a nonspecific sign of numerous retinal vascular diseases. This paper is an updated overview about the role of inflammatory processes in the genesis of both diabetic macular edema (DME) and ME secondary to retinal vein occlusion (RVO). We focus on the inflammatory mediators implicated, the effect of the different intravitreal therapies, the recruitment of leukocytes mediated by adhesion molecules, and the role of retinal Müller glial (RMG) cells.

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