scholarly journals BMI-Specific Waist Circumference Thresholds to Discriminate Elevated Cardiometabolic Risk in White and African American Adults

Obesity Facts ◽  
2013 ◽  
Vol 6 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Amanda E. Staiano ◽  
Claude Bouchard ◽  
Peter T. Katzmarzyk
Keyword(s):  
African American ◽  
Waist Circumference ◽  
Cardiometabolic Risk ◽  
African American Adults

Differential DNA Methylation and Cardiometabolic Risk in African American Mother-Adolescent Dyads

2021 ◽  
pp. 109980042110390
Author(s):  
Amanda Elswick Gentry ◽  
Jo Robins ◽  
Mat Makowski ◽  
Wendy Kliewer
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Dna Methylation ◽  
African American ◽  
African Americans ◽  
Waist Circumference ◽  
Low Income ◽  
Cardiometabolic Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

Background: Cardiovascular disease disproportionately affects African Americans as the leading cause of morbidity and mortality. Among African Americans, compared to other racial groups, cardiovascular disease onset occurs at an earlier age due to a higher prevalence of cardiometabolic risk factors, particularly obesity, hypertension and type 2 diabetes. Emerging evidence suggests that heritable epigenetic processes are related to increased cardiovascular disease risk, but this is largely unexplored in adolescents or across generations. Materials and Methods: In a cross-sectional descriptive pilot study in low-income African American mother-adolescent dyads, we examined associations between DNA methylation and the cardiometabolic indicators of body mass index, waist circumference, and insulin resistance. Results: Four adjacent cytosine and guanine nucleotides (CpG) sites were significantly differentially methylated and associated with C-reactive protein (CRP), 62 with waist circumference, and none to insulin resistance in models for both mothers and adolescents. Conclusion: Further study of the relations among psychological and environmental stressors, indicators of cardiovascular disease, risk, and epigenetic factors will improve understanding of cardiovascular disease risk so that preventive measures can be instituted earlier and more effectively. To our knowledge this work is the first to examine DNA methylation and cardiometabolic risk outcomes in mother-adolescent dyads.

scholarly journals Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study

2020 ◽  
Author(s):  
Tyler McDaniel ◽  
Dawn K Wilson ◽  
M Sandra Coulon ◽  
Allison M Sweeney ◽  
M Lee Van Horn
Keyword(s):  
African American ◽  
Waist Circumference ◽  
Genetic Risk ◽  
Social Life ◽  
Risk Model ◽  
Neighborhood Environment ◽  
Buccal Swab ◽  
Metabolic Risk ◽  
African American Adults ◽  
The Impact

Abstract Background Understanding determinants of metabolic risk has become a national priority given the increasingly high prevalence rate of this condition among U.S. adults. Purpose This study’s aim was to assess the impact of gene-by-neighborhood social environment interactions on waist circumference (WC) as a primary marker of metabolic risk in underserved African-American adults. Based on a dual-risk model, it was hypothesized that those with the highest genetic risk and who experienced negative neighborhood environment conditions would demonstrate higher WC than those with fewer risk factors. Methods This study utilized a subsample of participants from the Positive Action for Today’s Health environmental intervention to improve access and safety for walking in higher-crime neighborhoods, who were willing to provide buccal swab samples for genotyping stress-related genetic pathways. Assessments were conducted with 228 African-American adults at baseline, 12, 18, and 24 months. Results Analyses indicated three significant gene-by-environment interactions on WC outcomes within the sympathetic nervous system (SNS) genetic pathway. Two interactions supported the dual-risk hypotheses, including the SNS genetic risk-by-neighborhood social life interaction (b = −0.11, t(618) = −2.02, p = .04), and SNS genetic risk-by-informal social control interaction (b = −0.51, t(618) = −1.95, p = .05) on WC outcomes. These interactions indicated that higher genetic risk and lower social-environmental supports were associated with higher WC. There was also one significant SNS genetic risk-by-neighborhood satisfaction interaction (b = 1.48, t(618) = 2.23, p = .02) on WC that was inconsistent with the dual-risk pattern. Conclusions Findings indicate that neighborhood and genetic factors dually influence metabolic risk and that these relations may be complex and warrant further study. Trial Registration NCT01025726.

scholarly journals Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

2015 ◽  
Vol 24 (15) ◽  
pp. 4464-4479 ◽  
Author(s):  
Ellen W. Demerath ◽  
Weihua Guan ◽  
Megan L. Grove ◽  
Stella Aslibekyan ◽  
Michael Mendelson ◽  
...  
Keyword(s):  
African American ◽  
Waist Circumference ◽  
Association Study ◽  
African American Adults

scholarly journals Trunk Versus Extremity Adiposity and Cardiometabolic Risk Factors in White and African American Adults

Diabetes Care ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 1415-1418 ◽  
Author(s):  
G. Hu ◽  
C. Bouchard ◽  
G. A. Bray ◽  
F. L. Greenway ◽  
W. D. Johnson ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
African American Adults

Cultural Familiarity of Figurative Expressions From Three Music Genres and African American Adults

2016 ◽  
Vol 43 (Fall) ◽  
pp. 238-254
Author(s):  
Alaina S. Davis ◽  
Wilhelmina Wright-Harp ◽  
Jay Lucker ◽  
Joan Payne ◽  
Alfonso Campbell
Keyword(s):  
African American ◽  
African American Adults ◽  
Music Genres ◽  
Figurative Expressions

Toward Identifying Mild Cognitive Impairment in Hispanic and African American Adults

2017 ◽  
Vol 2 (2) ◽  
pp. 110-116
Author(s):  
Valarie B. Fleming ◽  
Joyce L. Harris
Keyword(s):  
Older Adults ◽  
African American ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthcare Access ◽  
Communication Disorders ◽  
Healthcare Systems ◽  
Prevention Education ◽  
Education Management ◽  
African American Adults

Across the breadth of acquired neurogenic communication disorders, mild cognitive impairment (MCI) may go undetected, underreported, and untreated. In addition to stigma and distrust of healthcare systems, other barriers contribute to decreased identification, healthcare access, and service utilization for Hispanic and African American adults with MCI. Speech-language pathologists (SLPs) have significant roles in prevention, education, management, and support of older adults, the population must susceptible to MCI.

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