scholarly journals Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

2015 ◽  
Vol 24 (15) ◽  
pp. 4464-4479 ◽  
Author(s):  
Ellen W. Demerath ◽  
Weihua Guan ◽  
Megan L. Grove ◽  
Stella Aslibekyan ◽  
Michael Mendelson ◽  
...  
Keyword(s):  
African American ◽  
Waist Circumference ◽  
Association Study ◽  
African American Adults

scholarly journals Interaction of Neighborhood and Genetic Risk on Waist Circumference in African-American Adults: A Longitudinal Study

2020 ◽  
Author(s):  
Tyler McDaniel ◽  
Dawn K Wilson ◽  
M Sandra Coulon ◽  
Allison M Sweeney ◽  
M Lee Van Horn
Keyword(s):  
African American ◽  
Waist Circumference ◽  
Genetic Risk ◽  
Social Life ◽  
Risk Model ◽  
Neighborhood Environment ◽  
Buccal Swab ◽  
Metabolic Risk ◽  
African American Adults ◽  
The Impact

Abstract Background Understanding determinants of metabolic risk has become a national priority given the increasingly high prevalence rate of this condition among U.S. adults. Purpose This study’s aim was to assess the impact of gene-by-neighborhood social environment interactions on waist circumference (WC) as a primary marker of metabolic risk in underserved African-American adults. Based on a dual-risk model, it was hypothesized that those with the highest genetic risk and who experienced negative neighborhood environment conditions would demonstrate higher WC than those with fewer risk factors. Methods This study utilized a subsample of participants from the Positive Action for Today’s Health environmental intervention to improve access and safety for walking in higher-crime neighborhoods, who were willing to provide buccal swab samples for genotyping stress-related genetic pathways. Assessments were conducted with 228 African-American adults at baseline, 12, 18, and 24 months. Results Analyses indicated three significant gene-by-environment interactions on WC outcomes within the sympathetic nervous system (SNS) genetic pathway. Two interactions supported the dual-risk hypotheses, including the SNS genetic risk-by-neighborhood social life interaction (b = −0.11, t(618) = −2.02, p = .04), and SNS genetic risk-by-informal social control interaction (b = −0.51, t(618) = −1.95, p = .05) on WC outcomes. These interactions indicated that higher genetic risk and lower social-environmental supports were associated with higher WC. There was also one significant SNS genetic risk-by-neighborhood satisfaction interaction (b = 1.48, t(618) = 2.23, p = .02) on WC that was inconsistent with the dual-risk pattern. Conclusions Findings indicate that neighborhood and genetic factors dually influence metabolic risk and that these relations may be complex and warrant further study. Trial Registration NCT01025726.

scholarly journals Epigenome-wide association study of metabolic syndrome in African-American adults

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Tomi Akinyemiju ◽  
Anh N. Do ◽  
Amit Patki ◽  
Stella Aslibekyan ◽  
Degui Zhi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African American ◽  
Association Study ◽  
African American Adults

Cultural Familiarity of Figurative Expressions From Three Music Genres and African American Adults

2016 ◽  
Vol 43 (Fall) ◽  
pp. 238-254
Author(s):  
Alaina S. Davis ◽  
Wilhelmina Wright-Harp ◽  
Jay Lucker ◽  
Joan Payne ◽  
Alfonso Campbell
Keyword(s):  
African American ◽  
African American Adults ◽  
Music Genres ◽  
Figurative Expressions

Toward Identifying Mild Cognitive Impairment in Hispanic and African American Adults

2017 ◽  
Vol 2 (2) ◽  
pp. 110-116
Author(s):  
Valarie B. Fleming ◽  
Joyce L. Harris
Keyword(s):  
Older Adults ◽  
African American ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthcare Access ◽  
Communication Disorders ◽  
Healthcare Systems ◽  
Prevention Education ◽  
Education Management ◽  
African American Adults

Across the breadth of acquired neurogenic communication disorders, mild cognitive impairment (MCI) may go undetected, underreported, and untreated. In addition to stigma and distrust of healthcare systems, other barriers contribute to decreased identification, healthcare access, and service utilization for Hispanic and African American adults with MCI. Speech-language pathologists (SLPs) have significant roles in prevention, education, management, and support of older adults, the population must susceptible to MCI.

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