scholarly journals Abdominal adiposity depots are correlates of adverse cardiometabolic risk factors in Caucasian and African-American adults

2011 ◽  
Vol 1 (1) ◽  
pp. e2-e2 ◽  
Author(s):  
R L Newton ◽  
C Bouchard ◽  
G Bray ◽  
F Greenway ◽  
W D Johnson ◽  
...  
Diabetes Care ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 1415-1418 ◽  
Author(s):  
G. Hu ◽  
C. Bouchard ◽  
G. A. Bray ◽  
F. L. Greenway ◽  
W. D. Johnson ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3244
Author(s):  
Whitney L. Do ◽  
Kai M. Bullard ◽  
Aryeh D. Stein ◽  
Mohammed K. Ali ◽  
K. M. Venkat Narayan ◽  
...  

In this study, we examined the associations between the consumption of foods derived from crops subsidized under the 2008 United States (US) Farm Bill and cardiometabolic risk factors and whether the magnitude of these associations has changed since the 2002 US Farm Bill. Four federal databases were used to estimate daily consumption of the top seven subsidized commodities (corn, soybeans, wheat, rice, sorghum, dairy, and livestock) and to calculate a subsidy score (0–1 scale) for Americans’ daily dietary intake during 2009–2014, with a higher score indicative of a higher proportion of the diet derived from subsidized commodities. The cardiometabolic risk factors included obesity, abdominal adiposity, hypertension, dyslipidemia, and dysglycemia. Linear and logistic regression models were adjusted for age, sex, race/ethnicity, the poverty–income ratio, the smoking status, educational attainment, physical activity, and daily calorie intake. During 2009–2014, adults with the highest subsidy score had higher probabilities of obesity, abdominal adiposity, and dysglycemia compared to the lowest subsidy score. After the 2002 Farm Bill (measured using data from 2001–2006), the subsidy score decreased from 56% to 50% and associations between consuming a highly-subsidized diet and dysglycemia did not change (p = 0.54), whereas associations with obesity (p = 0.004) and abdominal adiposity (p = 0.002) significantly attenuated by more than half. The proportion of calories derived from subsidized food commodities continues to be associated with adverse cardiometabolic risk factors, though the relationship with obesity and abdominal adiposity has weakened in recent years.


2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Rebecca E. Lee ◽  
Scherezade K. Mama ◽  
Ygnacio Lopez III

Findings from previous research linking sedentary time with cardiometabolic risk factors and body composition are inconsistent, and few studies address population groups most vulnerable to these compromising conditions. The purpose of this paper was to investigate the relationship of sitting time to cardiometabolic risk factors and body composition among African American women. A subsample of African American women (N=135) completed health and laboratory assessments, including measures of blood pressure, resting heart rate, cholesterol, triglycerides, glucose, body mass index, body fat, sitting time, and demographics. Simultaneous, adjusted regression models found a positive association between weekend sitting time and glucose and an inverse association between weekly sedentary time and cholesterol (ps<.05). There were no significant associations between sedentary behavior and body composition. The unexpected relationship between sedentary time and cholesterol suggests that the relationship of sedentary behavior to cardiometabolic risk factors may depend on existing characteristics of the population and measurement definition of sedentary behavior. Results suggest distinctly different relationships between weekend and weekday sitting time, implicating a need for careful measurement and intervention that reflects these differences.


2010 ◽  
Vol 62 (11) ◽  
pp. 3173-3182 ◽  
Author(s):  
Jon T. Giles ◽  
Matthew Allison ◽  
Roger S. Blumenthal ◽  
Wendy Post ◽  
Allan C. Gelber ◽  
...  

2014 ◽  
Vol 103 (3) ◽  
pp. e14-e17 ◽  
Author(s):  
David R. Weber ◽  
Lorraine E. Levitt Katz ◽  
Babette S. Zemel ◽  
Paul R. Gallagher ◽  
Kathryn M. Murphy ◽  
...  

2007 ◽  
Vol 31 (4) ◽  
pp. 692-699 ◽  
Author(s):  
M Côté ◽  
I Matias ◽  
I Lemieux ◽  
S Petrosino ◽  
N Alméras ◽  
...  

2019 ◽  
Vol 110 (5) ◽  
pp. 1079-1087 ◽  
Author(s):  
Anna Viitasalo ◽  
Theresia M Schnurr ◽  
Niina Pitkänen ◽  
Mette Hollensted ◽  
Tenna R H Nielsen ◽  
...  

ABSTRACT Background Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear. Objective We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization. Methods We constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3–17 y. Results WHRadjBMI GRS was associated with higher WHRadjBMI (β = 0.021 SD/allele; 95% CI: 0.016, 0.026 SD/allele; P = 3 × 10−15) and with unfavorable concentrations of blood lipids (higher LDL cholesterol: β = 0.006 SD/allele; 95% CI: 0.001, 0.011 SD/allele; P = 0.025; lower HDL cholesterol: β = −0.007 SD/allele; 95% CI: −0.012, −0.002 SD/allele; P = 0.009; higher triglycerides: β = 0.007 SD/allele; 95% CI: 0.002, 0.012 SD/allele; P = 0.006). No differences were detected between prepubertal and pubertal/postpubertal children. The WHRadjBMI GRS had a stronger association with fasting insulin in children and adolescents with overweight/obesity (β = 0.016 SD/allele; 95% CI: 0.001, 0.032 SD/allele; P = 0.037) than in those with normal weight (β = −0.002 SD/allele; 95% CI: −0.010, 0.006 SD/allele; P = 0.605) (P for difference = 0.034). In a 2-stage least-squares regression analysis, each genetically instrumented 1-SD increase in WHRadjBMI increased circulating triglycerides by 0.17 mmol/L (0.35 SD, P = 0.040), suggesting that the relation between abdominal adiposity and circulating triglycerides may be causal. Conclusions Abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood. The results highlight the importance of early weight management through healthy dietary habits and physically active lifestyle among children with a tendency for abdominal adiposity.


2015 ◽  
Vol 12 (8) ◽  
pp. 1148-1152 ◽  
Author(s):  
Daniel P. Bailey ◽  
Louise A. Savory ◽  
Sarah J. Denton ◽  
Catherine J. Kerr

Background:It is unclear whether cardiorespiratory fitness (CRF) is independently linked to cardiometabolic risk in children. This study investigated a) the association between CRF level and presence of cardiometabolic risk disorders using health-related cut points, and b) whether these associations were mediated by abdominal adiposity in children.Methods:This was a cross-sectional design study. Anthropometry, biochemical parameters and CRF were assessed in 147 schoolchildren (75 girls) aged 10 to 14 years. CRF was determined using a maximal cycle ergometer test. Children were classified as ‘fit’ or ‘unfit’ according to published thresholds. Logistic regression was used to investigate the odds of having individual and clustered cardiometabolic risk factors according to CRF level and whether abdominal adiposity mediated these associations.Results:Children classified as unfit had increased odds of presenting individual and clustered cardiometabolic risk factors (P < .05), but these associations no longer remained after adjusting for abdominal adiposity (P > .05).Conclusions:This study suggests that the association between CRF and cardiometabolic risk is mediated by abdominal adiposity in 10- to 14-year-old children and that abdominal adiposity may be a more important determinant of adverse cardiometabolic health in this age group.


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