Interleukin-8 Content in the Stratum Corneum as an Indicator of the Severity of Inflammation in the Lesions of Atopic Dermatitis

2013 ◽  
Vol 160 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Tseveendorj Amarbayasgalan ◽  
Hitoshi Takahashi ◽  
Itaru Dekio ◽  
Eishin Morita
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Interleukin 8

scholarly journals Interleukin-8 Levels in the Stratum Corneum as a Biomarker for Monitoring Therapeutic Effect in Atopic Dermatitis Patients

2021 ◽  
pp. 1-15
Author(s):  
Susumu Murata ◽  
Sakae Kaneko ◽  
Eishin Morita
Keyword(s):  
Atopic Dermatitis ◽  
Topical Corticosteroid ◽  
Stratum Corneum ◽  
Corticosteroid Treatment ◽  
Skin Inflammation ◽  
Interleukin 8 ◽  
Tape Stripping ◽  
Therapeutic Effects ◽  
Local Skin ◽  
Before And After

<b><i>Introduction:</i></b> The stratum corneum contains several growth factors and cytokines that are synthesized in keratinocytes. We previously reported that the amount of interleukin-8 in the stratum corneum (scIL-8) is related to the severity of local skin inflammation in atopic dermatitis (AD). However, it is unknown whether scIL-8 levels reflect pharmacologic responses to a therapeutic intervention in AD patients. Therefore, in this study, we aimed to investigate whether the improvement of dermatitis in AD is correlated with scIL-8 levels before and after topical corticosteroid treatment. <b><i>Methods:</i></b> Stratum corneum samples were collected from 22 AD patients using the noninvasive tape-stripping method before treatment, 2 weeks after topical treatment, and 4–6 weeks after treatment. <b><i>Results:</i></b> scIL-8 levels on the forearm reduced significantly from 790 ± 348 pg/mg before treatment to 163 ± 68 pg/mg 2 weeks after treatment and 100 ± 37 pg/mg 4–6 weeks after corticosteroid treatment. scIL-8 levels on the abdomen also reduced significantly from 902 ± 391 to 142 ± 38 pg/mg at the end of study. The reduction in scIL-8 levels was associated with the improvement in local skin severity in AD. We also found that scIL-8 levels, along with blood biomarker levels (serum thymus and activation-regulated chemokine, lactate dehydrogenase, and %eosinophil), decreased significantly after the treatment. <b><i>Conclusion:</i></b> The scIL-8 concentration decreases with improvements in skin symptoms in AD patients after topical corticosteroid treatment; thus, it may be a suitable biomarker for monitoring therapeutic effects in AD patients.

scholarly journals Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis

2018 ◽  
Vol 180 (3) ◽  
pp. 586-596 ◽  
Author(s):  
M.A. McAleer ◽  
I. Jakasa ◽  
G. Hurault ◽  
P. Sarvari ◽  
W.H.I. McLean ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis

2016 ◽  
Vol 308 (9) ◽  
pp. 631-642 ◽  
Author(s):  
Nükhet Cavusoglu ◽  
Caroline Delattre ◽  
Mark Donovan ◽  
Sylvie Bourassa ◽  
Arnaud Droit ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Quantitative Proteomics

Stratum corneum lipid abnormalities in atopic dermatitis

1991 ◽  
Vol 283 (4) ◽  
pp. 219-223 ◽  
Author(s):  
A. Yamamoto ◽  
S. Serizawa ◽  
M. Ito ◽  
Y. Sato
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Stratum Corneum Lipid ◽  
Lipid Abnormalities

Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis

Allergy ◽  
2010 ◽  
Author(s):  
E. Morita ◽  
H. Takahashi ◽  
H. Niihara ◽  
I. Dekio ◽  
Y. Sumikawa ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Skin Inflammation ◽  
Lesional Skin
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