scholarly journals Either transepidermal water loss rates or stratum corneum hydration levels can predict quality of life in children with atopic dermatitis

2021 ◽  
Author(s):  
Shan Wang ◽  
Chunping Shen ◽  
Mutong Zhao ◽  
Lei Jiao ◽  
Jing Tian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Stratum Corneum Hydration ◽  
Loss Rates

Testing an Ectoin Containing Emollient for Atopic Dermatitis

2019 ◽  
Vol 15 (3) ◽  
pp. 191-195
Author(s):  
Kam Lun Hon ◽  
Jeng Sum Kung ◽  
Wing Gi Gigi Ng ◽  
Ting Fan Leung
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Water Loss ◽  
Historical Data ◽  
Transepidermal Water Loss ◽  
Patient Acceptability ◽  
The Mean ◽  
Topical Medications ◽  
Colonization Status

Aim: To describe the methodology in studying patient’s acceptability and efficacy of an ectoin containing emollient for atopic dermatitis (AD). Methods: We described the methodology that we used in studying emollients and moisturisers, and patient acceptability of a group of AD patients before and following usage of an ectoin-containing proprietary emollient. These data were also compared with other brand emollients that we previously reported, namely Restoradom®, Ezerra® and Ezerra plus®. Results: 30 subjects (50% Male, Mean (SD) age: 9.8 (3.6) years with AD used the trial emollient W for four weeks. AD severity of subjects (by objective SCORAD) was moderate (n=22) and severe (n=8). Compliance was good and patients generally managed to use the moisturisers daily, with individual reports of a ‘tingly’ sensation by some subjects when applied to inflamed wounds. 63% reported “very good” or “good”, whereas 37% reported “fair” or “poor” acceptability of the moisturisers. Following use of the trial emollient, area affected, disease intensity and severity significantly improved, as demonstrated in objective SCORAD (p=0.002). There were also significant improvements in POEM (p=0.035), and PADQLQ scores (p=0.017). For skin measurements, only transepidermal water loss had improved (p=0.035) after the treatment. There was no significant improvement of itch or sleep scores, skin hydration, pH, S. aureus colonization status, or need for use of topical medications. When compared with historical data of other emollients, the mean age of patients on emollient W was younger; efficacy and acceptability among these emollients were similar. Conclusions: Methodology of emollient research is described. Doctors should provide evidencebased information about the efficacy of emollients. The ectoin-containing proprietary emollient improves disease and quality of life following its use in 4 weeks. Efficacy and acceptability are similar among 4 proprietary emollients.

Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men

2021 ◽  
pp. 1-7
Author(s):  
Atsushi Suzuki ◽  
Tomoko Nomura ◽  
Hiroko Jokura ◽  
Naoya Kitamura ◽  
Akihiko Fujii ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Stratum Corneum ◽  
Water Loss ◽  
Nervous Activity ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Sympathetic Nervous Activity ◽  
Healthy Men ◽  
Stratum Corneum Hydration ◽  
Sympathetic Nervous

Abstract. Ferulic acid (FA) is a phytochemical compound with various physiologic functions. To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. Sixteen healthy subjects were divided into 2 groups (n = 8) and ingested capsules containing either FA (200 mg) or placebo daily for 2 weeks. Two measures of SBF, transepidermal water loss and stratum corneum hydration, were assessed before and 2 weeks after the start of the study. Autonomic nervous activity, which is suggested to be related to SBF, was also measured. Compared with the values obtained before the start of the study, FA intake significantly reduced transepidermal water loss (from 6.1 ± 1.1 to 4.8 ± 1.0 g/m2/h, p = 0.005) and increased stratum corneum hydration (from 30.1 ± 7.6 to 32.3 ± 8.1 a.u., p = 0.027) after 2 weeks. In addition, the amount change in sympathetic nervous activity was significantly reduced after ingesting the FA capsules compared with the placebo capsules (−0.7 ± 1.6 vs. 1.1 ± 1.4, p = 0.035). These findings suggest that FA supplementation decreases sympathetic nervous activity and strengthens SBF in healthy men.

Effect of sock type on foot health

2019 ◽  
Vol 89 (18) ◽  
pp. 3871-3881 ◽  
Author(s):  
Rebecca Van Amber ◽  
Raechel M Laing ◽  
Cheryl A Wilson ◽  
Linda A Dunn ◽  
Tim Jowett
Keyword(s):  
Diabetes Mellitus ◽  
Stratum Corneum ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Fiber Content ◽  
Foot Health ◽  
Merino Wool ◽  
Stratum Corneum Hydration ◽  
Structure Changes ◽  
Over Time

The objective was to determine whether changes in indicators of skin health among participants suffering from diabetes mellitus could be attributable to the type of sock worn (fiber content, structure). Changes in skin health over time (e.g. temperature, skin hardness, transepidermal water loss, stratum corneum hydration) can indicate improvement or deterioration, and these may be related to socks worn. Socks of different structure (single jersey, terry), and of fiber content (merino wool, cotton) were worn over a period of 22 weeks by participants suffering from diabetes mellitus. Each participant was their own control: change over time in skin hardness, stratum corneum hydration, transepidermal water loss and temperatures were monitored. Properties of the sock fabrics were measured as new and after use to determine effects of wear. Limited evidence of improved skin health was attributable to socks composed primarily of wool.

scholarly journals Differences in the stratum corneum of Indonesian infants and adults

2017 ◽  
Vol 57 (1) ◽  
pp. 35
Author(s):  
Tsutomu Fujimura ◽  
Kyoko Shima ◽  
Yuki Miyauchi ◽  
Mitsuyuki Hotta ◽  
Hiroshi Hashimoto ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Water Loss ◽  
Skin Diseases ◽  
Transepidermal Water Loss ◽  
Skin Care ◽  
Full Term ◽  
Basic Knowledge ◽  
Upper Arm ◽  
Term Infants

Background Although understanding the stratum corneum (SC) of infant skin is important to avoid skin diseases such as atopic dermatitis, there has been no such investigation in Indonesian infants to date.Objective  To obtain a basic knowledge of SC characteristics in Indonesian infants in order to develop methods for infant-specific skin care and to prevent dermatitis and infection.Methods Seventy-two healthy, full term infants aged 1 to 24 months who were native Indonesians residing in Jakarta were enrolled in this study. Some of the mothers were also enrolled in the study as adults (n=30). Transepidermal water loss (TEWL) and hydration of the SC (capacitance) on the thigh, buttock, and upper arm were measured after sufficient acclimation in an air-conditioned room, in both infants and mothers. Results The SC hydration was significantly higher in infants than adults at all sites measured, including the buttocks, which is a diaper area. Infant TEWL values were also significantly higher than in adults at all sites. Hydration of the SC and TEWL values showed no significant correlation with age of infant for any site. The SC hydration and TEWL values of Indonesian infants did not decrease to adult values within 24 months, which indicates that the SC characteristics in infants continue to develop after 24 months of age.Conclusion  Indonesian infants aged 0-24 months have significantly higher SC hydration and TEWL values than Indonesian mothers. However, infant age has no correlation to SC hydration or to TEWL values.

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