Elevated Levels of Interleukin-33 in the Nasal Secretions of Patients with Allergic Rhinitis

2012 ◽  
Vol 158 (s1) ◽  
pp. 47-50 ◽  
Author(s):  
Daiya Asaka ◽  
Mamoru Yoshikawa ◽  
Tsuguhisa Nakayama ◽  
Tsuyoshi Yoshimura ◽  
Hiroshi Moriyama ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Interleukin 33 ◽  
Nasal Secretions

scholarly journals Influence of interleukin-33 gene expression on clinical and morphological characteristics of the nasal mucosa in allergic rhinitis

Immunologiya ◽  
2021 ◽  
Vol 42 (1) ◽  
pp. 68-79
Author(s):  
S.A. Gusniev ◽  
◽  
S.A. Polner ◽  
L.M. Mikhaleva ◽  
N.I. Ilina ◽  
...  
Keyword(s):  
Gene Expression ◽  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Morphological Characteristics ◽  
Interleukin 33

scholarly journals Probiotic therapy on children with allergic rhinitis

2016 ◽  
Vol 53 (5) ◽  
pp. 264
Author(s):  
Franky Luhulima ◽  
IPG Karyana ◽  
Sumadiono Sumadiono
Keyword(s):  
Allergic Rhinitis ◽  
Placebo Group ◽  
Standard Therapy ◽  
Controlled Trial ◽  
Nasal Symptom ◽  
Probiotic Supplementation ◽  
Double Blind ◽  
Probiotic Group ◽  
Probiotic Treatment ◽  
Nasal Secretions

phils in nasal secretions of patients with allergic rhinitis may cause persistent nasal blockage. A common therapy for allergic rhinitis is oral or intranasal corticosteroids. However, corticosteroids carry the risk of disrupting growth and development in children. Probiotic treatment in allergic rhinitis patients works by manipulating the bacterial ecosystem of the digestive tract, stimulating the balance of Th1 and Th2 immune responses.Objective To assess the effects of probiotic supplementation on eosinophil levels in nasal secretions, duration of allergic episodes, and total nasal symptom scores in children aged 2-18 years with allergic rhinitis.Methods A randomized, double-blind, controlled trial was performed on children aged 2 to 18 years who visited Sanglah Hospital, Denpasar, between March to July 2012 due to allergic rhinitis. Fifty-five eligible subjects were involved in the study. Subjects were randomly allocated to receive either standard therapy (antihistamines) and probiotics or standard therapy and placebo for 30 days. Mann-Whitney test was used for statistical non-parametric unpaired samples analysis. P values of <0.05 were considered to be statistically significant.Results Fifty-five subjects with allergic rhinitis were randomized into either the probiotic group (27 subjects) or the placebo group (28 subjects). We found that the median (range) nasal eosinophil percentage reduction before the study compared to after 30 days of treatment was higher in the probiotic group than in the placebo group (34 (15-65) vs 6 (0-24) %, respectively, P<0.0001). Median (range) duration of allergic rhinitis episode in the probiotic group was shorter compared to the placebo group (48 (0-96) hours vs 72 (6-168) hours, respectively; P<0.0001). The median (range) total nasal symptom score was also lower in the probiotic group compared to the placebo group (2 (0-3) vs 5 (1-6), respectively; P<0.0001).Conclusion Probiotic supplementation reduces the percentage of nasal eosinophils, duration of allergic rhinitis episode, and total nasal symptoms.

scholarly journals Reliability Assessment of the Endoscopic Examination in Patients with Allergic Rhinitis

2016 ◽  
Vol 7 (3) ◽  
pp. ar.2016.7.0176
Author(s):  
Georges K. Ziade ◽  
Reem A. Karami ◽  
Ghina B. Fakhri ◽  
Elie S. Alam ◽  
Abdul Latif Hamdan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Endoscopic Examination ◽  
Nasal Endoscope ◽  
Mild Disease ◽  
Endoscopic Findings ◽  
Interrater Variability ◽  
Mucosal Edema ◽  
Nasal Secretions ◽  
A Prospective Study ◽  
Bluish Discoloration

Objective To study if nasal endoscope can be a reliable tool in assessing patients with allergic rhinitis. Materials and Methods A prospective study. Patients who were diagnosed with allergic rhinitis underwent a nasal endoscopic examination performed by two physicians blinded to the scoring of each other. A correlation was made among symptom severity, endoscopic findings, and interrater variability. Results Ninety patients were included in the study: 34 patients had mild disease and 56 had moderate-to-severe allergic rhinitis according to the Allergic Rhinitis and its Impact on Asthma guidelines. Increases in mucosal edema and bluish discoloration were predictive of the severity of allergic rhinitis disease (p < 0.05). The presence of nasal secretions was not predictive of allergic rhinitis. Interrater reliability was fair for mucosal edema, moderate-to-almost perfect for the rest of the endoscopic findings. Conclusion Nasal endoscopy may reveal signs that are predictive of the severity of allergic rhinitis. A detailed checklist is needed for the nasal endoscopic examination to decrease interrater variability.

Quantitative Cytology of Nasal Secretions With Perennial Allergic Rhinitis in Children: Comparison of Noninfected and Infected Conditions

1998 ◽  
Vol 108 (5) ◽  
pp. 703-705 ◽  
Author(s):  
Jun Shinogi ◽  
Yuichi Majima ◽  
Kazuhiko Takeuchi ◽  
Teruhiko Harada ◽  
Yasuo Sakakura
Keyword(s):  
Allergic Rhinitis ◽  
Perennial Allergic Rhinitis ◽  
Quantitative Cytology ◽  
Nasal Secretions

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

2015 ◽  
Vol 6 (4) ◽  
pp. 392-397 ◽  
Author(s):  
Aleksandar Perić ◽  
Jelena Sotirović ◽  
Cveta Špadijer-Mirković ◽  
Svjetlana Matković-Jožin ◽  
Aneta V. Perić ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Secretions

Nasal Responses to Metabisulfite (MBS) Solution in Non-Atopic Subjects and Patients with Atopic Rhinitis

1994 ◽  
Vol 8 (5) ◽  
pp. 231-236 ◽  
Author(s):  
Mariola Śliwińska-Kowalska ◽  
Marek L. Kowalski ◽  
Wiestaw Sutkowski ◽  
Wiktor Wesotowski ◽  
Melvyn R. Danzig
Keyword(s):  
Allergic Rhinitis ◽  
Total Protein ◽  
Clinical Symptoms ◽  
Nasal Congestion ◽  
Absolute Amount ◽  
Protein Ratio ◽  
Nasal Symptoms ◽  
Before And After ◽  
Nasal Secretions ◽  
Dose Dependent Increase

In order to characterize the effect of metabisulfite (MBS) on human nasal mucosa, in 10 healthy, non-atopic subjects and in six patients with atopic rhinitis, 50 mg/mL and 100 mg/mL solutions of MBS were sprayed into both nostrils. Clinical symptoms and Nasal Peak Flow (NPF) were recorded. Nasal lavages were performed before and after MBS challenges. MBS challenge induced similar burning/itching sensation in both groups, but rhinorrhea was significantly more intense (P < 0.02) in atopic patients. There was no nasal congestion and no change in NPF after the challenge. Only in atopic patients were nasal symptoms accompanied by a dose-dependent increase in the concentration of total protein and glandular protein lysozyme in nasal washes (P < 0.05). No statistically significant changes were seen in the absolute amount of plasma protein albumin and albumin to total protein ratio (Albumin %) in nasal secretions. This study demonstrates that MBS induces nasal symptoms both in healthy, non-atopic subjects and in patients with allergic rhinitis; but secretory glandular responses are detected only in patients with allergic rhinitis.

scholarly journals Efektivitas terapi komplementer propolis telaah terhadap SGHT dan IL-33 sekret hidung penderita rinitis alergi

2019 ◽  
Vol 49 (1) ◽  
pp. 57
Author(s):  
Yunis Sucipta Ibnu ◽  
Dwi Reno Pawarti ◽  
Mansyur Siddiq Wiyadi
Keyword(s):  
Clinical Trial ◽  
Allergic Rhinitis ◽  
Randomized Clinical Trial ◽  
Standard Therapy ◽  
Nasal Secretion ◽  
Tropical Disease ◽  
Double Blind ◽  
Interleukin 33 ◽  
Group A ◽  
Group B

Latar belakang: Rinitis alergi (RA) adalah inflamasi mukosa hidung yang diperantarai oleh IgE. Gejala dapat dinilai dengan Skor Gejala Hidung Total (SGHT). Patofisiologi dan manifestasi klinis RA dipengaruhi oleh berbagai sitokin diantaranya interleukin 33 (IL-33). Efektivitas propolis maupun flavonoid dalam menurunkan SGHT dan kadar IL-33 sekret hidung masih kontroversi. Tujuan: Membuktikan bahwa penambahan propolis pada terapi komplementer RA lebih efektif menurunkan SGHT dan kadar IL-33 sekret hidung. Metode: Penelitian double blind randomized clinical trial (RCT), dilakukan di Unit Rawat Jalan (URJ) Divisi Alergi Imunologi, Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher (THT-KL) RSUD Dr. Soetomo, dan Institute of Tropical Disease, Universitas Airlangga, Surabaya pada bulan September 2018-Januari 2019. Pasien RA yang memenuhi kriteria inklusi diperiksa SGHT dan kadar IL-33 sekret hidung. Terapi diberikan selama 14 hari, evaluasi SGHT dan kadar IL-33 dilakukan hari ke-15. Hasil: Sepuluh sampel mendapat propolis dan terapi standar (kelompok A), sepuluh sampel mendapat terapi standar (kelompok B). Perbandingan SGHT antar kelompok setelah terapi rerata kelompok A=1,6 (SD 1,7), kelompok B=5,2 (SD 1,6). Uji Mann-Whitney satu arah p=0,001 menunjukkan SGHT antar kelompok setelah terapi berbeda signifikan (p<0,005). Rerata kadar IL-33 setelah terapi kelompok A=0,051 (SD 0,005), kelompok B=0,051 (SD 0,013). Uji t nilai p=0,881 menunjukkan kadar IL-33 sekret hidung antar kelompok setelah terapi berbeda tidak signifikan (p>0,005). Kesimpulan: Penambahan propolis sebagai terapi komplementer lebih efektif dalam menurunkan SGHT dibandingkan dengan terapi standar saja, namun tidak efektif dalam menurunkan kadar IL-33 sekret hidung penderita RA. Background: Allergic rhinitis (AR) is a nasal mucosa inflammation mediated by IgE. The symptoms severity is determined by total nasal symptom score (TNSS). The pathophysiology and clinical manifestations of AR are affected by several cytokines, one of which is interleukin 33 (IL-33). Efficacy of propolis or flavonoid in reducing TNSS and IL-33 level in nasal secretion is still a controversy. Purpose: To find out whether propolis addition to standard therapy could be more effective in reducing TNSS and IL-33 level of nasal secretion. Method: Double blind randomized clinical trial (RCT). The study was conducted at Outpatient unit of Department of Allergic and Immunology, Dr. Soetomo General Hospital, Surabaya and Institute of Tropical Disease (ITD) Universitas Airlangga. Allergic rhinitis patients who met inclusion criteria were examined for TNSS and IL-33 nasal secretion level. Therapy was given for 14 days, after which TNSS and IL-33 levels were evaluated on day 15th. Ten samples received propolis and standard therapy (group A), ten samples received standard therapy only (group B). Result: The comparison of TNSS groups after treatment: mean group A=1.6 (SD 1.7), and mean group B=5.2 (SD 1.6). One way Mann-Whitney test showed p=0.001 indicating the TNSS after treatment was significantly different (p<0.005). The comparison of IL-33: mean group A=0.051(SD=0.005) and mean group B=0.051(SD=0.013), t-test p=0.0881 indicating the IL-33 level of nasal secretion after treatment was not significantly different (p>0.005). Conclusion: Propolis as a complementary therapy was more effective reducing TNSS compared to standard therapy only, but it was not effective in reducing IL-33 level of nasal secretion.

Understanding Allergic Rhinitis: Differential Diagnosis and Management

1986 ◽  
Vol 7 (7) ◽  
pp. 212-218
Author(s):  
Gail G. Shapiro
Keyword(s):  
Allergic Rhinitis ◽  
Differential Diagnosis ◽  
Physical Examination ◽  
Therapeutic Response ◽  
Skin Testing ◽  
Common Condition ◽  
Chronic Rhinitis ◽  
Nasal Secretions ◽  
Frequent Reason ◽  
Substantial Morbidity

Chronic rhinitis is a common condition responsible for a substantial morbidity. Allergic rhinitis is the most frequent reason for chronic rhinitis in children. The physician must begin any evaluation with a thorough history and physical examination. Specific questions concerning the environment will be important if allergy is a possible diagnosis. The microscopic examination of nasal secretions may be helpful in corroborating evidence. Treatment of allergic rhinitis should include a serious attempt to avoid exacerbating factors that have been identified from the history. Pharmacologic intervention with antihistamines, decongestants, and topical use of cromolyn or corticosteroids may be highly successful. If such therapy must be constant to achieve an adequate therapeutic response or if the response is suboptimal, an evaluation for specific allergies, including skin testing to identify pertinent allergens, should be considered.

Eosinophil Cationic Protein in the Nasal Secretions of Patients With Mite Allergic Rhinitis

1993 ◽  
Vol 103 (3) ◽  
pp. 189???192 ◽  
Author(s):  
Keiko Nishioka ◽  
Chisato Saito ◽  
Toshiaki Nagano ◽  
Mitsuhiro Okano ◽  
Yu Masuda ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Nasal Secretions
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