Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

2015 ◽  
Vol 6 (4) ◽  
pp. 392-397 ◽  
Author(s):  
Aleksandar Perić ◽  
Jelena Sotirović ◽  
Cveta Špadijer-Mirković ◽  
Svjetlana Matković-Jožin ◽  
Aneta V. Perić ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Secretions

scholarly journals Probiotic therapy on children with allergic rhinitis

2016 ◽  
Vol 53 (5) ◽  
pp. 264
Author(s):  
Franky Luhulima ◽  
IPG Karyana ◽  
Sumadiono Sumadiono
Keyword(s):  
Allergic Rhinitis ◽  
Placebo Group ◽  
Standard Therapy ◽  
Controlled Trial ◽  
Nasal Symptom ◽  
Probiotic Supplementation ◽  
Double Blind ◽  
Probiotic Group ◽  
Probiotic Treatment ◽  
Nasal Secretions

phils in nasal secretions of patients with allergic rhinitis may cause persistent nasal blockage. A common therapy for allergic rhinitis is oral or intranasal corticosteroids. However, corticosteroids carry the risk of disrupting growth and development in children. Probiotic treatment in allergic rhinitis patients works by manipulating the bacterial ecosystem of the digestive tract, stimulating the balance of Th1 and Th2 immune responses.Objective To assess the effects of probiotic supplementation on eosinophil levels in nasal secretions, duration of allergic episodes, and total nasal symptom scores in children aged 2-18 years with allergic rhinitis.Methods A randomized, double-blind, controlled trial was performed on children aged 2 to 18 years who visited Sanglah Hospital, Denpasar, between March to July 2012 due to allergic rhinitis. Fifty-five eligible subjects were involved in the study. Subjects were randomly allocated to receive either standard therapy (antihistamines) and probiotics or standard therapy and placebo for 30 days. Mann-Whitney test was used for statistical non-parametric unpaired samples analysis. P values of <0.05 were considered to be statistically significant.Results Fifty-five subjects with allergic rhinitis were randomized into either the probiotic group (27 subjects) or the placebo group (28 subjects). We found that the median (range) nasal eosinophil percentage reduction before the study compared to after 30 days of treatment was higher in the probiotic group than in the placebo group (34 (15-65) vs 6 (0-24) %, respectively, P<0.0001). Median (range) duration of allergic rhinitis episode in the probiotic group was shorter compared to the placebo group (48 (0-96) hours vs 72 (6-168) hours, respectively; P<0.0001). The median (range) total nasal symptom score was also lower in the probiotic group compared to the placebo group (2 (0-3) vs 5 (1-6), respectively; P<0.0001).Conclusion Probiotic supplementation reduces the percentage of nasal eosinophils, duration of allergic rhinitis episode, and total nasal symptoms.

scholarly journals Reliability Assessment of the Endoscopic Examination in Patients with Allergic Rhinitis

2016 ◽  
Vol 7 (3) ◽  
pp. ar.2016.7.0176
Author(s):  
Georges K. Ziade ◽  
Reem A. Karami ◽  
Ghina B. Fakhri ◽  
Elie S. Alam ◽  
Abdul Latif Hamdan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Endoscopic Examination ◽  
Nasal Endoscope ◽  
Mild Disease ◽  
Endoscopic Findings ◽  
Interrater Variability ◽  
Mucosal Edema ◽  
Nasal Secretions ◽  
A Prospective Study ◽  
Bluish Discoloration

Objective To study if nasal endoscope can be a reliable tool in assessing patients with allergic rhinitis. Materials and Methods A prospective study. Patients who were diagnosed with allergic rhinitis underwent a nasal endoscopic examination performed by two physicians blinded to the scoring of each other. A correlation was made among symptom severity, endoscopic findings, and interrater variability. Results Ninety patients were included in the study: 34 patients had mild disease and 56 had moderate-to-severe allergic rhinitis according to the Allergic Rhinitis and its Impact on Asthma guidelines. Increases in mucosal edema and bluish discoloration were predictive of the severity of allergic rhinitis disease (p < 0.05). The presence of nasal secretions was not predictive of allergic rhinitis. Interrater reliability was fair for mucosal edema, moderate-to-almost perfect for the rest of the endoscopic findings. Conclusion Nasal endoscopy may reveal signs that are predictive of the severity of allergic rhinitis. A detailed checklist is needed for the nasal endoscopic examination to decrease interrater variability.

Quantitative Cytology of Nasal Secretions With Perennial Allergic Rhinitis in Children: Comparison of Noninfected and Infected Conditions

1998 ◽  
Vol 108 (5) ◽  
pp. 703-705 ◽  
Author(s):  
Jun Shinogi ◽  
Yuichi Majima ◽  
Kazuhiko Takeuchi ◽  
Teruhiko Harada ◽  
Yasuo Sakakura
Keyword(s):  
Allergic Rhinitis ◽  
Perennial Allergic Rhinitis ◽  
Quantitative Cytology ◽  
Nasal Secretions

Nasal Responses to Metabisulfite (MBS) Solution in Non-Atopic Subjects and Patients with Atopic Rhinitis

1994 ◽  
Vol 8 (5) ◽  
pp. 231-236 ◽  
Author(s):  
Mariola Śliwińska-Kowalska ◽  
Marek L. Kowalski ◽  
Wiestaw Sutkowski ◽  
Wiktor Wesotowski ◽  
Melvyn R. Danzig
Keyword(s):  
Allergic Rhinitis ◽  
Total Protein ◽  
Clinical Symptoms ◽  
Nasal Congestion ◽  
Absolute Amount ◽  
Protein Ratio ◽  
Nasal Symptoms ◽  
Before And After ◽  
Nasal Secretions ◽  
Dose Dependent Increase

In order to characterize the effect of metabisulfite (MBS) on human nasal mucosa, in 10 healthy, non-atopic subjects and in six patients with atopic rhinitis, 50 mg/mL and 100 mg/mL solutions of MBS were sprayed into both nostrils. Clinical symptoms and Nasal Peak Flow (NPF) were recorded. Nasal lavages were performed before and after MBS challenges. MBS challenge induced similar burning/itching sensation in both groups, but rhinorrhea was significantly more intense (P < 0.02) in atopic patients. There was no nasal congestion and no change in NPF after the challenge. Only in atopic patients were nasal symptoms accompanied by a dose-dependent increase in the concentration of total protein and glandular protein lysozyme in nasal washes (P < 0.05). No statistically significant changes were seen in the absolute amount of plasma protein albumin and albumin to total protein ratio (Albumin %) in nasal secretions. This study demonstrates that MBS induces nasal symptoms both in healthy, non-atopic subjects and in patients with allergic rhinitis; but secretory glandular responses are detected only in patients with allergic rhinitis.

Understanding Allergic Rhinitis: Differential Diagnosis and Management

1986 ◽  
Vol 7 (7) ◽  
pp. 212-218
Author(s):  
Gail G. Shapiro
Keyword(s):  
Allergic Rhinitis ◽  
Differential Diagnosis ◽  
Physical Examination ◽  
Therapeutic Response ◽  
Skin Testing ◽  
Common Condition ◽  
Chronic Rhinitis ◽  
Nasal Secretions ◽  
Frequent Reason ◽  
Substantial Morbidity

Chronic rhinitis is a common condition responsible for a substantial morbidity. Allergic rhinitis is the most frequent reason for chronic rhinitis in children. The physician must begin any evaluation with a thorough history and physical examination. Specific questions concerning the environment will be important if allergy is a possible diagnosis. The microscopic examination of nasal secretions may be helpful in corroborating evidence. Treatment of allergic rhinitis should include a serious attempt to avoid exacerbating factors that have been identified from the history. Pharmacologic intervention with antihistamines, decongestants, and topical use of cromolyn or corticosteroids may be highly successful. If such therapy must be constant to achieve an adequate therapeutic response or if the response is suboptimal, an evaluation for specific allergies, including skin testing to identify pertinent allergens, should be considered.

Eosinophil Cationic Protein in the Nasal Secretions of Patients With Mite Allergic Rhinitis

1993 ◽  
Vol 103 (3) ◽  
pp. 189???192 ◽  
Author(s):  
Keiko Nishioka ◽  
Chisato Saito ◽  
Toshiaki Nagano ◽  
Mitsuhiro Okano ◽  
Yu Masuda ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Nasal Secretions

Elevated Levels of Interleukin-33 in the Nasal Secretions of Patients with Allergic Rhinitis

2012 ◽  
Vol 158 (s1) ◽  
pp. 47-50 ◽  
Author(s):  
Daiya Asaka ◽  
Mamoru Yoshikawa ◽  
Tsuguhisa Nakayama ◽  
Tsuyoshi Yoshimura ◽  
Hiroshi Moriyama ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Interleukin 33 ◽  
Nasal Secretions

scholarly journals Current Update of Local Allergic Rhinitis

2021 ◽  
Vol 64 (8) ◽  
pp. 533-539
Author(s):  
Su-Jong Kim ◽  
Jee Won Moon ◽  
Heung-Man Lee
Keyword(s):  
Allergic Rhinitis ◽  
Provocation Test ◽  
High Sensitivity ◽  
Specific Ige ◽  
Nasal Provocation Test ◽  
Local Allergic Rhinitis ◽  
Nasal Provocation ◽  
Nasal Secretions ◽  
Positive Results ◽  
A Current

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The symptoms, duration, severity, and comorbidities of LAR are similar to those of allergic rhinitis. Although pathophysiology of LAR is not fully understood, in some patients specific IgE can be demonstrated in the nasal secretions. The diagnosis currently relies on the positive results of nasal provocation test. Nasal provocation test has shown high sensitivity and specificity with safety, and is considered as the gold standard. LAR patients benefit from the same therapeutic strategies as allergic rhinitis patients, including the avoidance of allergen exposure and the pharmacotherapy. Effectiveness and safety of allergen immunotherapy open a window of treatment opportunity in LAR. This review provides a current update on LAR.

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