Differential Hemodynamic Effects of Levosimendan in a Porcine Model of Neonatal Hypoxia-Reoxygenation

Neonatology ◽  
2012 ◽  
Vol 101 (3) ◽  
pp. 192-200 ◽  
Author(s):  
J. Esch ◽  
C. Joynt ◽  
N. Manouchehri ◽  
T.F. Lee ◽  
Y.-Q. Li ◽  
...  
Keyword(s):  
Porcine Model ◽  
Hemodynamic Effects ◽  
Neonatal Hypoxia ◽  
Hypoxia Reoxygenation

scholarly journals PS-159 Beta-amyloid And S100b Could Be Valuable Biomarkers After Neonatal Hypoxia-reoxygenation. A Study In Newborn Pigs

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A168.2-A168
Author(s):  
T Benterud ◽  
L Pankratov ◽  
R Solberg ◽  
OD Saugstad ◽  
A Skinningsrud ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Neonatal Hypoxia ◽  
Newborn Pigs ◽  
Hypoxia Reoxygenation

scholarly journals A comparison of the hemodynamic effects of tracheal administration of vasopressin, adrenaline, and vasopressin plus adrenaline in a porcine model

2012 ◽  
Vol 2 (4) ◽  
pp. 103-106
Author(s):  
Pei-Chen Lin ◽  
Hung-Jung Lin ◽  
How-Ran Guo ◽  
Chih-Chan Lin ◽  
Kuo-Tai Chen
Keyword(s):  
Porcine Model ◽  
Hemodynamic Effects

Doxycycline Attenuates Renal Injury In A Swine Model Of Neonatal Hypoxia-Reoxygenation

Shock ◽  
2015 ◽  
Vol 43 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Joseph R. Labossiere ◽  
Jean-Sebastian Pelletier ◽  
Aducio Thiesen ◽  
Richard Schulz ◽  
David L. Bigam ◽  
...  
Keyword(s):  
Renal Injury ◽  
Swine Model ◽  
Neonatal Hypoxia ◽  
Hypoxia Reoxygenation

Hemodynamic Effects of Spiral ePTFE Prosthesis Compared with Standard Arteriovenous Graft in a Carotid to Jugular Vein Porcine Model

2010 ◽  
Vol 12 (3) ◽  
pp. 224-230 ◽  
Author(s):  
Ommid Kh. Jahrome ◽  
Imo Hoefer ◽  
Graeme J. Houston ◽  
Peter A. Stonebridge ◽  
Peter J. Blankestijn ◽  
...  
Keyword(s):  
Porcine Model ◽  
Jugular Vein ◽  
Arteriovenous Graft ◽  
Hemodynamic Effects

Abstract 19325: Hemodynamic Effects of Guideline-compliant Asynchronous vs. Synchronous Ventilations During Cardiopulmonary Resuscitation in a Porcine Model

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Christiane Skåre ◽  
Theresa Olasveengen ◽  
Jo Kramer-Johansen ◽  
Fredrik Nordum ◽  
Eriksen Morten ◽  
...  
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Porcine Model ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Right Atrial ◽  
Hemodynamic Effects ◽  
Chest Compressions ◽  
Hemodynamic Variables ◽  
Airway Pressures ◽  
Normal Chest

Background: Current guidelines for cardiopulmonary resuscitation (CPR) emphasize reducing pauses in chest compressions, and suggest ventilating with 1 second inspiration time and with enough volume to produce normal chest rise 10 times per minute. No specific advice is provided on how ventilations should be timed with ongoing chest compressions. We have compared hemodynamic effects of ventilating synchronously vs. asynchronously during chest compressions in a porcine model. Methods: Twenty anaesthetized domestic pigs (approx. 30 kg) were randomized into two groups; synchronous vs. asynchronous ventilation. Ventricular fibrillation is induced electrically and left for 2 minutes before initiation of basic 30:2 CPR for 4 minutes. CPR with continuous mechanical chest compressions was continued for another 8 minutes with either synchronous or asynchronous ventilation before defibrillation was attempted. Aortic, right atrial and intracerebral pressures, carotid and cerebral blood flow and cardiac output (thermodilution) were measured. Airway monitoring included capnography and spirometry. Results: Hemodynamics, blood gas analysis and airway pressures were similar for both groups during baseline and 30:2 CPR periods. The asynchronous group had higher median peak inspiratory airway pressure (94 vs. 57 cm H 2 O, p<0.001) and lower EtCO 2 (1.8 vs. 3.5 kPa, p=0.023) compared to synchronous group during the last 30 seconds of CPR (after 12 minutes). Asynchronous group also had higher pH (7.55 vs. 7.35, p<0.001), lower pCO 2 (2.4 vs. 4.7, p<0.001) and higher pO 2 (62.1 vs. 29.4, p<0.001) compared to synchronous group. There were no significant differences in any of the measured hemodynamic variables between the two groups with similar coronary and cerebral perfusion pressures. ROSC was achieved in 5/10 vs. 3/10 animals in the synchronous and asynchronous groups, respectively. Conclusion: Synchronous and asynchronous ventilation during mechanical chest compressions provide similar hemodynamics, but guideline-compliant asynchronous ventilation yields significantly higher airway pressures and hyperventilation. Implications for lung injury need to be assessed.

Activated Protein C in the Cardioplegic Solution on a Porcine Model of Coronary Ischemia-Reperfusion has Deleterious Hemodynamic Effects

2006 ◽  
Vol 20 (2) ◽  
pp. 113-121 ◽  
Author(s):  
José A. Fernández ◽  
Antti E. Vento ◽  
Mikko Jormalainen ◽  
John H. Griffin ◽  
Ero Pesonen ◽  
...  
Keyword(s):  
Protein C ◽  
Porcine Model ◽  
Ischemia Reperfusion ◽  
Activated Protein C ◽  
Hemodynamic Effects ◽  
Cardioplegic Solution ◽  
Coronary Ischemia

Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury

2008 ◽  
Vol 53 (2) ◽  
pp. 190-202 ◽  
Author(s):  
C. K. MARUMO ◽  
D. A. OTSUKI ◽  
D. T. FANTONI ◽  
C. B. MARGARIDO ◽  
A. M. AMBRÓSIO ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Porcine Model ◽  
Hemodynamic Effects
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