Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones

Oncology ◽  
2010 ◽  
Vol 78 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Shiou-Hwei Yeh ◽  
Pei-Jer Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Gender Disparity

scholarly journals Interplay of Sphingosine1 phosphate, Adiponectin and Sex Hormones with Gender disparity among patients with Hepatocellular Carcinoma

2021 ◽  
Author(s):  
ragaa abdelshaheed matta ◽  
mohamed shatat ◽  
Mahmoud Mahrous Sedik ◽  
Mostafa Ahmed EL Sayed Abu Elela
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Screening Test ◽  
Healthy Subjects ◽  
Experimental Studies ◽  
Gender Disparity ◽  
Tnm Staging ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Male And Female

Abstract Backgroundcirculating sphingosine 1-phosphate (S1P) showed oncogenic roles in various cancers. It showed conflict data in Hepatitis B virus- hepatocellular carcinoma (HCC). Adiponectin and sex hormones were contributing factors for gender disparity in HCC. Up to date, no clinical study among HCC patients addresses interplay of S1P, adiponectin and sex hormones that was described in experimental studies. The current study aimed to evaluate circulating SIP, adiponectin and sex hormones among sex stratified HCC subgroups and to assess gender disparity of theses parameters regarding HCC development and diagnosis, their interplay and association with clinic -morphological and staging of HCC.MethodWe measures serum S1P, adiponectin, testosterone (T), estradiol (E) and sex hormone binding globulin (SHBG), calculated free and bioavailable T and E/T ratio among HCV – HCC group in comparing with comparable HCV- cirrhotic and healthy groups with their sex stratified male and female subgroupsResultsAmong all, male and female HCC patients, S1P was significant higher than corresponding cirrhotic and healthy subjects with cut off value ≥ 113ng/l as screening test (sensitivity 95%, specificity 56%) for HCC diagnosis. Compared to sex respective cirrhotic subgroups, male-HCC had significant higher SHBG and lower adiponectin and estradiol while opposite profile was observed among female-HCC. Female-HCC had significant higher SIP and adiponectin than male-HCC. Although S1P was positively correlated with adiponectin, testosterone and negatively with E/T ratio among male and female HCC, adiponectin was correlated negatively with testosterone and SHBG and positively with estradiol and E/T ratio among entire HCC group but reverse associations were observed in female (not- male) subgroup. Associations of large tumor size and higher T-class TNM staging with higher adiponectin and testosterone and lower E/T ratio and link of multiplicity with higher estradiol in females while association of higher testosterone among higher T-class TNM staging male were observed. Portal vein thrombosis was related to lower SHBG and higher testosterone in male and female respectively.ConclusionWe suggested S1P as screening test for diagnosis of HCC among HCV-cirrhotic and healthy subjects. There was gender disparity as regard association and interaction of S1P, adiponectin and sex hormone with respect of HCC development and its clinic-morphological features and staging.

scholarly journals Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Montella ◽  
Giovanni D’Arena ◽  
Anna Crispo ◽  
Mario Capunzo ◽  
Flavia Nocerino ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sex Hormones ◽  
Molecular Mechanisms ◽  
Developed Countries ◽  
Gender Disparity ◽  
Mrna Levels ◽  
Effective Prevention ◽  
B Virus

Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC. While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels. Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue. This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections. Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases.

Gender disparity in hepatocellular carcinoma (HCC): multiple underlying mechanisms

2017 ◽  
Vol 60 (6) ◽  
pp. 575-584 ◽  
Author(s):  
Bo Zheng ◽  
Yan-Jing Zhu ◽  
Hong-Yang Wang ◽  
Lei Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gender Disparity ◽  
Underlying Mechanisms

scholarly journals Gender disparity in HCC: Is it the fat and not the sex?

2019 ◽  
Vol 216 (5) ◽  
pp. 1014-1015 ◽  
Author(s):  
Tim F. Greten
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gender Disparity

Men are more likely to develop hepatocellular carcinoma (HCC) than women, but it is not clear why. In this issue of JEM, Manieri et al. (https://doi.org/10.1084/jem.20181288) identify reduced adiponectin levels as responsible for the increased incidence of HCC in males.

Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: A randomized, controlled trial

Hepatology ◽  
1995 ◽  
Vol 21 (6) ◽  
pp. 1535-1542 ◽  
Author(s):  
Emanuel K. Manesis ◽  
Gregory Giannoulis ◽  
Pavlos Zoumboulis ◽  
Irini Vafiadou ◽  
Stephanos J. Hadziyannis
Keyword(s):  
Hepatocellular Carcinoma ◽  
Randomized Controlled Trial ◽  
Sex Hormones ◽  
Controlled Trial ◽  
Randomized Controlled
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