scholarly journals Gender disparity in HCC: Is it the fat and not the sex?

2019 ◽  
Vol 216 (5) ◽  
pp. 1014-1015 ◽  
Author(s):  
Tim F. Greten
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gender Disparity

Men are more likely to develop hepatocellular carcinoma (HCC) than women, but it is not clear why. In this issue of JEM, Manieri et al. (https://doi.org/10.1084/jem.20181288) identify reduced adiponectin levels as responsible for the increased incidence of HCC in males.

Gender disparity in hepatocellular carcinoma (HCC): multiple underlying mechanisms

2017 ◽  
Vol 60 (6) ◽  
pp. 575-584 ◽  
Author(s):  
Bo Zheng ◽  
Yan-Jing Zhu ◽  
Hong-Yang Wang ◽  
Lei Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gender Disparity ◽  
Underlying Mechanisms

Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones

Oncology ◽  
2010 ◽  
Vol 78 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Shiou-Hwei Yeh ◽  
Pei-Jer Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Gender Disparity

Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma

2017 ◽  
Vol 410 ◽  
pp. 20-31 ◽  
Author(s):  
Chang Liu ◽  
Yi-Fan Ren ◽  
Jian Dong ◽  
Meng-Yun Ke ◽  
Feng Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gender Disparity ◽  
Male Specific

scholarly journals Interplay of Sphingosine1 phosphate, Adiponectin and Sex Hormones with Gender disparity among patients with Hepatocellular Carcinoma

2021 ◽  
Author(s):  
ragaa abdelshaheed matta ◽  
mohamed shatat ◽  
Mahmoud Mahrous Sedik ◽  
Mostafa Ahmed EL Sayed Abu Elela
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Screening Test ◽  
Healthy Subjects ◽  
Experimental Studies ◽  
Gender Disparity ◽  
Tnm Staging ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Male And Female

Abstract Backgroundcirculating sphingosine 1-phosphate (S1P) showed oncogenic roles in various cancers. It showed conflict data in Hepatitis B virus- hepatocellular carcinoma (HCC). Adiponectin and sex hormones were contributing factors for gender disparity in HCC. Up to date, no clinical study among HCC patients addresses interplay of S1P, adiponectin and sex hormones that was described in experimental studies. The current study aimed to evaluate circulating SIP, adiponectin and sex hormones among sex stratified HCC subgroups and to assess gender disparity of theses parameters regarding HCC development and diagnosis, their interplay and association with clinic -morphological and staging of HCC.MethodWe measures serum S1P, adiponectin, testosterone (T), estradiol (E) and sex hormone binding globulin (SHBG), calculated free and bioavailable T and E/T ratio among HCV – HCC group in comparing with comparable HCV- cirrhotic and healthy groups with their sex stratified male and female subgroupsResultsAmong all, male and female HCC patients, S1P was significant higher than corresponding cirrhotic and healthy subjects with cut off value ≥ 113ng/l as screening test (sensitivity 95%, specificity 56%) for HCC diagnosis. Compared to sex respective cirrhotic subgroups, male-HCC had significant higher SHBG and lower adiponectin and estradiol while opposite profile was observed among female-HCC. Female-HCC had significant higher SIP and adiponectin than male-HCC. Although S1P was positively correlated with adiponectin, testosterone and negatively with E/T ratio among male and female HCC, adiponectin was correlated negatively with testosterone and SHBG and positively with estradiol and E/T ratio among entire HCC group but reverse associations were observed in female (not- male) subgroup. Associations of large tumor size and higher T-class TNM staging with higher adiponectin and testosterone and lower E/T ratio and link of multiplicity with higher estradiol in females while association of higher testosterone among higher T-class TNM staging male were observed. Portal vein thrombosis was related to lower SHBG and higher testosterone in male and female respectively.ConclusionWe suggested S1P as screening test for diagnosis of HCC among HCV-cirrhotic and healthy subjects. There was gender disparity as regard association and interaction of S1P, adiponectin and sex hormone with respect of HCC development and its clinic-morphological features and staging.

scholarly journals Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity

2010 ◽  
Vol 127 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Anna Ruggieri ◽  
Cristiana Barbati ◽  
Walter Malorni
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Mechanisms ◽  
Gender Disparity

scholarly journals A Male-ABCD Algorithm for Hepatocellular Carcinoma Risk Prediction in HBsAg Carriers

2021 ◽  
Author(s):  
Yuting Wang ◽  
Minjie Wang ◽  
He Li ◽  
Kun Chen ◽  
Hongmei Zeng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Prediction ◽  
Hepatitis B Surface Antigen ◽  
Population Based ◽  
Gender Disparity ◽  
Low Risk ◽  
Operating Characteristics ◽  
Logistic Regression Models ◽  
Hbsag Carriers ◽  
Potential Risk Factors

Abstract BACKGROUND: Hepatocellular carcinoma (HCC) development among hepatitis B surface antigen (HBsAg) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBsAg-positive male adults.METHODS: HBsAg-positive, 35-69 years males (N=6 153) were recruited from a multi-center population-based liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using B-ultrasonography and α-fetoprotein (AFP). We used logistic regression models to determine potential risk factors, built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.RESULTS: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant’s Age, Blood levels of GGT (γ-glutamyl-transpeptidase), Counts of platelets, white cells, Concentration of DCP (des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.89-0.93), larger than existing models. At 1.5 points of risk-score, 26.10% of the participants in training, 14.94% in validation were recognized at-low-risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training, 33.68% in validation were recognized at-low-risk with 99.06% and 97.78% of sensitivity. At 4.5 points, only 20.86% of training, 23.73% of validation were recognized at-high-risk, with positive prediction value of 22.85% and 12.35% respectively.DISCUSSION: Male-ABCD algorithm identified individual’s risk for HCC occurrence within short-term for their HCC precision surveillance.

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