scholarly journals Gender disparity shown during regression of EGFR/MYC-driven hepatocellular carcinoma involved with sex hormones in transgenic zebrafish liver tumor model

2017 ◽  
Vol 145 ◽  
pp. S33
Author(s):  
Hankun Li ◽  
Xiaojing Huo ◽  
Zhen Li ◽  
Zhiyuan Gong
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Liver Tumor ◽  
Tumor Model ◽  
Gender Disparity ◽  
Transgenic Zebrafish ◽  
Zebrafish Liver

Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones

Oncology ◽  
2010 ◽  
Vol 78 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Shiou-Hwei Yeh ◽  
Pei-Jer Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Gender Disparity

Effects of sex hormones on liver tumor progression and regression in Myc/xmrk double oncogene transgenic zebrafish

2019 ◽  
Vol 277 ◽  
pp. 112-121 ◽  
Author(s):  
Hankun Li ◽  
Jeng-Wei Lu ◽  
Xiaojing Huo ◽  
Yan Li ◽  
Zhen Li ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Sex Hormones ◽  
Liver Tumor ◽  
Transgenic Zebrafish

scholarly journals Inducible Liver Cancer Models in Transgenic Zebrafish to Investigate Cancer Biology

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5148
Author(s):  
Ai Qi Lee ◽  
Yan Li ◽  
Zhiyuan Gong
Keyword(s):  
Liver Cancer ◽  
Cancer Biology ◽  
Cancer Cachexia ◽  
Rapid Change ◽  
Tumour Microenvironment ◽  
Gender Disparity ◽  
Transgenic Zebrafish ◽  
Environmental Toxicants ◽  
Cancer Models ◽  
Zebrafish Liver

Primary liver cancer is one of the most prevalent and deadly cancers, which incidence continues to increase while treatment response remains poor; thus, in-depth understanding of tumour events is necessary to develop more effective therapies. Animal models for liver cancer are powerful tools to reach this goal. Over the past decade, our laboratory has established multiple oncogene transgenic zebrafish lines that can be robustly induced to develop liver cancer. Histological, transcriptomic and molecular analyses validate the use of these transgenic zebrafish as experimental models for liver cancer. In this review, we provide a comprehensive summary of our findings with these inducible zebrafish liver cancer models in tumour initiation, oncogene addiction, tumour microenvironment, gender disparity, cancer cachexia, drug screening and others. Induced oncogene expression causes a rapid change of the tumour microenvironment such as inflammatory responses, increased vascularisation and rapid hepatic growth. In several models, histologically-proven carcinoma can be induced within one week of chemical inducer administration. Interestingly, the induced liver tumours show the ability to regress when the transgenic oncogene is suppressed by the withdrawal of the chemical inducer. Like human liver cancer, there is a strong bias of liver cancer severity in male zebrafish. After long-term tumour progression, liver cancer-bearing zebrafish also show symptoms of cancer cachexia such as muscle-wasting. In addition, the zebrafish models have been used to screen for anti-metastasis drugs as well as to evaluate environmental toxicants in carcinogenesis. These findings demonstrated that these inducible zebrafish liver cancer models provide rapid and convenient experimental tools for further investigation of fundamental cancer biology, with the potential for the discovery of new therapeutic approaches.

scholarly journals Interplay of Sphingosine1 phosphate, Adiponectin and Sex Hormones with Gender disparity among patients with Hepatocellular Carcinoma

2021 ◽  
Author(s):  
ragaa abdelshaheed matta ◽  
mohamed shatat ◽  
Mahmoud Mahrous Sedik ◽  
Mostafa Ahmed EL Sayed Abu Elela
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sex Hormones ◽  
Screening Test ◽  
Healthy Subjects ◽  
Experimental Studies ◽  
Gender Disparity ◽  
Tnm Staging ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Male And Female

Abstract Backgroundcirculating sphingosine 1-phosphate (S1P) showed oncogenic roles in various cancers. It showed conflict data in Hepatitis B virus- hepatocellular carcinoma (HCC). Adiponectin and sex hormones were contributing factors for gender disparity in HCC. Up to date, no clinical study among HCC patients addresses interplay of S1P, adiponectin and sex hormones that was described in experimental studies. The current study aimed to evaluate circulating SIP, adiponectin and sex hormones among sex stratified HCC subgroups and to assess gender disparity of theses parameters regarding HCC development and diagnosis, their interplay and association with clinic -morphological and staging of HCC.MethodWe measures serum S1P, adiponectin, testosterone (T), estradiol (E) and sex hormone binding globulin (SHBG), calculated free and bioavailable T and E/T ratio among HCV – HCC group in comparing with comparable HCV- cirrhotic and healthy groups with their sex stratified male and female subgroupsResultsAmong all, male and female HCC patients, S1P was significant higher than corresponding cirrhotic and healthy subjects with cut off value ≥ 113ng/l as screening test (sensitivity 95%, specificity 56%) for HCC diagnosis. Compared to sex respective cirrhotic subgroups, male-HCC had significant higher SHBG and lower adiponectin and estradiol while opposite profile was observed among female-HCC. Female-HCC had significant higher SIP and adiponectin than male-HCC. Although S1P was positively correlated with adiponectin, testosterone and negatively with E/T ratio among male and female HCC, adiponectin was correlated negatively with testosterone and SHBG and positively with estradiol and E/T ratio among entire HCC group but reverse associations were observed in female (not- male) subgroup. Associations of large tumor size and higher T-class TNM staging with higher adiponectin and testosterone and lower E/T ratio and link of multiplicity with higher estradiol in females while association of higher testosterone among higher T-class TNM staging male were observed. Portal vein thrombosis was related to lower SHBG and higher testosterone in male and female respectively.ConclusionWe suggested S1P as screening test for diagnosis of HCC among HCV-cirrhotic and healthy subjects. There was gender disparity as regard association and interaction of S1P, adiponectin and sex hormone with respect of HCC development and its clinic-morphological features and staging.

scholarly journals Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Montella ◽  
Giovanni D’Arena ◽  
Anna Crispo ◽  
Mario Capunzo ◽  
Flavia Nocerino ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sex Hormones ◽  
Molecular Mechanisms ◽  
Developed Countries ◽  
Gender Disparity ◽  
Mrna Levels ◽  
Effective Prevention ◽  
B Virus

Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC. While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels. Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue. This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections. Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases.

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