Effects of Nifedipine on Normotensive Rat Placental Blood Flow, Placental Weight and Fetal Weight

1991 ◽  
Vol 32 (1) ◽  
pp. 1-3 ◽  
Author(s):  
N. Furuhashi ◽  
M. Tsujiei ◽  
H. Kimura ◽  
A. Yajima
Keyword(s):  
Blood Flow ◽  
Placental Weight ◽  
Fetal Weight ◽  
Placental Blood ◽  
Placental Blood Flow

Measurement of Placental Blood Flow in the Pig and Its Relation to Placental and Fetal Weight

Neonatology ◽  
1977 ◽  
Vol 31 (5-6) ◽  
pp. 333-339 ◽  
Author(s):  
R. Wootton ◽  
I.R. McFadyen ◽  
J.E. Cooper
Keyword(s):  
Blood Flow ◽  
Fetal Weight ◽  
Placental Blood ◽  
Placental Blood Flow

Chronic maternal hypertension characterized by renal dysfunction is associated with reduced placental blood flow during late gestation in rabbits

2010 ◽  
Vol 298 (4) ◽  
pp. R1043-R1049 ◽  
Author(s):  
Adelle M. McArdle ◽  
Claire T. Roberts ◽  
Devaki Maduwegedera ◽  
Rebecca L. Flower ◽  
Kate M. Denton
Keyword(s):  
Blood Flow ◽  
Sham Group ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Placental Weight ◽  
Late Gestation ◽  
Maternal Hypertension ◽  
Placental Blood ◽  
Placental Efficiency ◽  
Placental Blood Flow

Maternal hypertension associated with renal disease is a common pregnancy complication. Previously, we have shown in a rabbit model of mild hypertension that offspring from hypertensive mothers have increased blood pressure as adults. In human pregnancy, hypertension has been associated with decreased utero-placental blood flow. The aim of this study was to determine placental blood flow (PBF) in mild (2-kidney-1-wrapped; 2K-1W) and moderate (2-kidney-2-wrapped; 2K-2W) rabbit models of maternal hypertension. We hypothesized that PBF would be inversely related to the severity of the hypertension. PBF and renal blood flow (RBF) were measured using microspheres on day 28 of a 32-day gestation, in normotensive (sham), 2K-1W, and 2K-2W hypertensive groups. Mean arterial pressure (MAP, ∼7 mmHg, P < 0.05) was increased, and RBF (∼35%, P < 0.05) was reduced in the 2K-1W and 2K-2W (MAP ∼20 mmHg, P < 0.01; RBF ∼53%, P < 0.05) groups compared with the sham group. In the 2K-1W group, PBF fell by ∼12% ( P = 0.08) and fetal-to-placental weight ratio increased by ∼12% ( P < 0.01) compared with the sham group, reflecting an increase in the functional capacity of the placenta to deliver nutrients to the fetus. In the 2K-2W group, PBF decreased ∼51% ( P < 0.05) compared with the sham group, without changes in placental efficiency. Thus, in late gestation, placental blood flow was significantly reduced in the moderate hypertension group, without accompanying changes in fetal or placental weight or placental efficiency. In contrast, mild hypertension resulted in an increase in placental efficiency, without significant changes in placental blood flow. These findings suggest that mild and moderate hypertension may alter placental delivery of nutrients via differing mechanisms dependent upon the severity of the hypertension.

Placental Blood Flow and Fetal Weight following Uterine Artery Ligation

Neonatology ◽  
1986 ◽  
Vol 49 (3) ◽  
pp. 172-180 ◽  
Author(s):  
Thomas Jansson ◽  
Magnus Thordstein ◽  
Ingemar Kjellmer
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Fetal Weight ◽  
Artery Ligation ◽  
Uterine Artery Ligation ◽  
Placental Blood ◽  
Placental Blood Flow

scholarly journals Non-invasive evaluation of placental blood flow: lessons from animal models

Reproduction ◽  
2017 ◽  
Vol 153 (3) ◽  
pp. R85-R96 ◽  
Author(s):  
E Mourier ◽  
A Tarrade ◽  
J Duan ◽  
C Richard ◽  
C Bertholdt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Animal Models ◽  
Ultrasound Contrast Agents ◽  
Valuable Insight ◽  
Non Invasive ◽  
Placental Blood ◽  
2D And 3D ◽  
Reliable Methods ◽  
Placental Blood Flow ◽  
Invasive Evaluation

In human obstetrics, placental vascularisation impairment is frequent as well as linked to severe pathological events (preeclampsia and intrauterine growth restriction), and there is a need for reliable methods allowing non-invasive evaluation of placental blood flow. Uteroplacental vascularisation is complex, and animal models are essential for the technical development and safety assessment of these imaging tools for human clinical use; however, these techniques can also be applied in the veterinary context. This paper reviews how ultrasound-based imaging methods such as 2D and 3D Doppler can provide valuable insight for the exploration of placental blood flow both in humans and animals and how new approaches such as the use of ultrasound contrast agents or ultrafast Doppler may allow to discriminate between maternal (non-pulsatile) and foetal (pulsatile) blood flow in the placenta. Finally, functional magnetic resonance imaging could also be used to evaluate placental blood flow, as indicated by studies in animal models, but its safety in human pregnancy still requires to be confirmed.

Effect of terbutaline sulphate on ovarian, uterine and maternal placental blood flow in the anaesthetized guinea pig

1978 ◽  
Vol 53 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Lena Mårtensson ◽  
Per-Ove B. Sjöquist ◽  
Leif Bjellin ◽  
Anthony M. Carter
Keyword(s):  
Blood Flow ◽  
Guinea Pig ◽  
Terbutaline Sulphate ◽  
Placental Blood ◽  
Placental Blood Flow
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