Effects of Thromboxane Synthetase Inhibitor (OKY-046) on Placental Blood Flow, Placental Weight and Fetal Weight in Normotensive and Spontaneously Hypertensive Rats

1993 ◽  
Vol 35 (1) ◽  
pp. 23-26 ◽  
Author(s):  
N. Furuhashi ◽  
M. Tsujiei ◽  
H. Kimura ◽  
H. Nagae ◽  
A. Yajima
Keyword(s):  
Blood Flow ◽  
Spontaneously Hypertensive Rats ◽  
Placental Weight ◽  
Fetal Weight ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Synthetase Inhibitor ◽  
Thromboxane Synthetase ◽  
Placental Blood ◽  
Placental Blood Flow

scholarly journals Effect of thromboxane synthetase inhibitor, OKY-046, on brain ischemia in spontaneously hypertensive rats.

Nosotchu ◽  
1989 ◽  
Vol 11 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Seizo Sadoshima ◽  
Takao Ishitsuka ◽  
Kenichiro Fujii ◽  
Yasushi Okada ◽  
Masatoshi Fujishima
Keyword(s):  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Synthetase Inhibitor ◽  
Thromboxane Synthetase Inhibitor ◽  
Thromboxane Synthetase

Excess oxygen delivery during muscle contractions in spontaneously hypertensive rats

1995 ◽  
Vol 78 (1) ◽  
pp. 101-111 ◽  
Author(s):  
J. M. Lash ◽  
H. G. Bohlen
Keyword(s):  
Blood Flow ◽  
Oxygen Saturation ◽  
Oxygen Delivery ◽  
Spontaneously Hypertensive Rats ◽  
Muscle Contractions ◽  
Hypertensive Rats ◽  
Hemoglobin Oxygen Saturation ◽  
Spontaneously Hypertensive ◽  
Tissue Po2 ◽  
Wistar Kyoto

These experiments determined whether a deficit in oxygen supply relative to demand could account for the sustained decrease in tissue PO2 observed during contractions of the spinotrapezius muscle in spontaneously hypertensive rats (SHR). Relative changes in blood flow were determined from measurements of vessel diameter and red blood cell velocity. Venular hemoglobin oxygen saturation measurements were performed by using in vivo spectrophotometric techniques. The relative dilation [times control (xCT)] of arteriolar vessels during contractions was as large or greater in SHR than in normotensive rats (Wistar-Kyoto), as were the increases in blood flow (2 Hz, 3.50 +/- 0.69 vs. 3.00 +/- 1.05 xCT; 4 Hz, 10.20 +/- 3.06 vs. 9.00 +/- 1.48 xCT; 8 Hz, 16.40 +/- 3.95 vs. 10.70 +/- 2.48 xCT). Venular hemoglobin oxygen saturation was lower in the resting muscle of SHR than of Wistar-Kyoto rats (31.0 +/= 3.0 vs. 43.0 +/- 1.9%) but was higher in SHR after 4- and 8-Hz contractions (4 Hz, 52.0 +/- 4.8 vs. 43.0 +/- 3.6%; 8 Hz, 51.0 +/- 4.6 vs. 41.0 +/- 3.6%). Therefore, an excess in oxygen delivery occurs relative to oxygen use during muscle contractions in SHR. The previous and current results can be reconciled by considering the possibility that oxygen exchange is limited in SHR by a decrease in anatomic or perfused capillary density, arteriovenular shunting of blood, or decreased transit time of red blood cells through exchange vessels.

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