Casein Phosphopeptide-Amorphous Calcium Phosphate Incorporated into Sugar Confections Inhibits the Progression of Enamel Subsurface Lesions in situ

2010 ◽  
Vol 44 (1) ◽  
pp. 33-40 ◽  
Author(s):  
G.D. Walker ◽  
F. Cai ◽  
P. Shen ◽  
G.G. Adams ◽  
C. Reynolds ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Casein Phosphopeptide

Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate

2008 ◽  
Vol 87 (4) ◽  
pp. 344-348 ◽  
Author(s):  
E.C. Reynolds ◽  
F. Cai ◽  
N.J. Cochrane ◽  
P. Shen ◽  
G.D. Walker ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Double Blind ◽  
Water Slurry ◽  
Supragingival Plaque ◽  
Casein Phosphopeptide

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.

scholarly journals Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

2013 ◽  
Vol 32 (4) ◽  
pp. 648-653 ◽  
Author(s):  
Rathapong THEPYOU ◽  
Wanvipa CHANMITKUL ◽  
Ornnicha THANATVARAKORN ◽  
Hidenori HAMBA ◽  
Wanwalai CHOB-ISARA ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Glass Ionomer ◽  
Caries Lesion ◽  
Casein Phosphopeptide

scholarly journals Efficacy of casein derivate CPP-ACP1

2014 ◽  
Vol 62 (3) ◽  
pp. 243-252
Author(s):  
Renata Faria PEREIRA ◽  
Soraya Coelho LEAL
Keyword(s):  
Calcium Phosphate ◽  
Randomized Controlled Trials ◽  
Systematic Reviews ◽  
Amorphous Calcium Phosphate ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Pubmed Database ◽  
Casein Phosphopeptide

OBJECTIVE: A literature review of systematic reviews and in situ and in vivo randomized controlled trials was conducted in order to assess the role of casein phosphopeptide - amorphous calcium phosphate in providing caries-preventive effect superior to any intervention or placebo. METHODS: Initially, Pubmed database was searched for systematic reviews. Two systematic reviews were identified, which concluded that the quantity and quality of randomized controlled trials were insufficient to recommend the clinical use of the product. After this, Pubmed database was searched for in situ and in vivo randomized controlled trials that were not included in the reviews identified. In vivo and in situ studies yielded mixed results. RESULTS: In situ studies indicated greater efficacy of casein phosphopeptide - amorphous calcium phosphate in comparison with placebo. Whereas, in vivo studies demonstrated different findings CONCLUSION: Casein phosphopeptide - amorphous calcium phosphate had a performance equivalent to or greater efficacy than placebo; fluoride was more effective than the casein complex; casein phosphopeptide - amorphous calcium phosphate associated with fluoride showed better or equivalent performance to that of placebo. In view of available evidence, it was not possible to generalize the indication of casein phosphopeptide - amorphous calcium phosphate for preventing dental caries. Further studies on the preventive effect and longer treatment applications are recommended.

Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate

2006 ◽  
Vol 73 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Glenn Walker ◽  
Fan Cai ◽  
Peiyan Shen ◽  
Coralie Reynolds ◽  
Brent Ward ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Tooth Enamel ◽  
Bovine Milk ◽  
Double Blind ◽  
Milk Samples ◽  
Randomized Clinical Study ◽  
Casein Phosphopeptide ◽  
Control Milk

Casein phosphopeptide amorphous calcium phosphate nanocomplexes (CPP-ACP) in chewing gum, lozenges and mouthrinses have been shown to remineralize enamel subsurface lesions in human in situ experiments. The aim of this double-blind, randomized clinical study was to investigate the capacity of CPP-ACP added to bovine milk to remineralize enamel subsurface lesions in situ. Ten subjects drank milk containing either 2·0 or 5·0 g CPP-ACP/l or a control milk whilst wearing removable appliances with enamel slabs containing subsurface demineralized lesions. Each 200 ml milk sample was consumed once a day for each weekday over three consecutive weeks. After each treatment and one weeks rest the subjects crossed over to the other treatments. At the completion of the treatments the enamel slabs were removed and remineralization determined using microradiography and microdensitometry. The results demonstrated that all three milk samples remineralized enamel subsurface lesions. However, the milk samples containing CPP-ACP produced significantly greater remineralization than the control milk. The remineralising effect of CPP-ACP in milk was dose-dependent with 2·0 and 5·0 g CPP-ACP/l producing an increase in mineral content of 70 and 148%, respectively, relative to the control milk. The differences in remineralization following exposure to the three milk samples were all statistically significant (P<0·001). In conclusion, this study shows that the addition of 2·0–5·0 g CPP-ACP/l to milk substantially increases its ability to remineralize enamel subsurface lesions.

scholarly journals Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia

2021 ◽  
pp. 1-10
Author(s):  
Ahmed Sleibi ◽  
Anwar R. Tappuni ◽  
Aylin Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Primary Root ◽  
Severity Index ◽  
Salivary Flow ◽  
Root Caries ◽  
Carious Lesions ◽  
Group 2 ◽  
Casein Phosphopeptide ◽  
Group 1

Different formulas of topical fluoride have been used to manage root carious lesions. This clinical trial aimed to investigate the efficacy of a dental varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride compared with fluoride alone in reversing/arresting root caries in xerostomic patients over 1 year. A total of 80 patients (age range 45–92 years) with primary root caries (<i>n</i> = 184 root carious lesions) and unstimulated salivary flow rate of &#x3c;0.2 mL/min were randomly allocated to receive either dental varnish containing CPP-ACP and 5% fluoride (group 1: MI varnish; GC, Japan) (<i>n</i> = 41, 83 lesions), or dental varnish with 5% fluoride alone (group 2: NUPRO White; Dentsply, USA) (<i>n</i> = 39, 101 lesions). Clinical assessments with Severity Index (SI) for root caries, DIAGNOdent measurements, and varnish application were carried out at baseline, 3, 6, and 12 months. Standard oral hygiene instructions with 1,450 ppm fluoride toothpastes were provided for both groups. After 3 months, 63.9% (<i>n</i> = 46) of root caries in group 1 became hard (SI: 0) compared with 39.3% (<i>n</i> = 35) in group 2 (<i>p</i> &#x3c; 0.01). After 6 and 12 months, the differences in SI were insignificant (group 1, <i>n</i> = 60, 83.3%) (group 2, <i>n</i> = 66, 74.2%) (<i>p</i> = 0.36), and (group 1, <i>n</i> = 60, 89.6%) (group 2, <i>n</i> = 67, 81.7%, <i>n</i> = 1 soft, 1.2%) (<i>p</i> = 0.29), respectively. In both groups, noncavitated leathery lesions were more likely to become hard when compared to the cavitated root caries. A significant decrease in plaque index, surface roughness, lesion dimension, and DIAGNOdent readings with a significant increase in lesion distance from the gingival margin was reported in both groups (<i>p</i> &#x3c; 0.05). This study has provided evidence that fluoride dental varnish either with or without calcium and phosphate has the potential to arrest/reverse root caries, especially noncavitated lesions for patients with xerostomia.

Casein phosphopeptide–amorphous calcium phosphate fluoride treatment enriches the symbiotic dental plaque microbiome in children

2021 ◽  
Vol 106 ◽  
pp. 103582
Author(s):  
Armelia Sari Widyarman ◽  
Nadeeka S. Udawatte ◽  
Citra Fragrantia Theodorea ◽  
Anie Apriani ◽  
Mario Richi ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Dental Plaque ◽  
Fluoride Treatment ◽  
Casein Phosphopeptide

Efficacy of in-office bleaching techniques combined with the application of a casein phosphopeptide-amorphous calcium phosphate paste at different moments and its influence on enamel surface properties

2012 ◽  
Vol 75 (8) ◽  
pp. 1019-1025 ◽  
Author(s):  
Ana Gabriela Gama Cunha ◽  
Adriana Alcantara Meira De Vasconcelos ◽  
Boniek Castillo Dutra Borges ◽  
Jussier De Oliveira Vitoriano ◽  
Clodomiro Alves-Junior ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Surface Properties ◽  
Amorphous Calcium Phosphate ◽  
Enamel Surface ◽  
Casein Phosphopeptide
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