Effect of Addition of Citric Acid and Casein Phosphopeptide-Amorphous Calcium Phosphate to a Sugar-Free Chewing Gum on Enamel Remineralization in situ

2007 ◽  
Vol 41 (5) ◽  
pp. 377-383 ◽  
Author(s):  
F. Cai ◽  
D.J. Manton ◽  
P. Shen ◽  
G.D. Walker ◽  
K.J. Cross ◽  
...  
Keyword(s):  
Citric Acid ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Chewing Gum ◽  
Casein Phosphopeptide

Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate

2008 ◽  
Vol 87 (4) ◽  
pp. 344-348 ◽  
Author(s):  
E.C. Reynolds ◽  
F. Cai ◽  
N.J. Cochrane ◽  
P. Shen ◽  
G.D. Walker ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Double Blind ◽  
Water Slurry ◽  
Supragingival Plaque ◽  
Casein Phosphopeptide

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slows the progression of caries and remineralizes enamel subsurface lesions. The aim of this study was to determine the ability of CPP-ACP to increase the incorporation of fluoride into plaque and to promote enamel remineralization in situ. Randomized, double-blind, cross-over studies involved mouthrinses and dentifrices containing CPP-ACP and fluoride. The mouthrinses were used for 60 sec, three times/day for 5 days, and supragingival plaque was collected and analyzed for F. The dentifrices were rinsed as a water slurry for 60 sec four times/day for 14 days in an in situ model. The addition of 2% CPP-ACP to the 450-ppm-F mouthrinse significantly increased the incorporation of fluoride into plaque. The dentifrice containing 2% CPP-ACP produced a level of remineralization similar to that achieved with a dentifrice containing 2800 ppm F. The dentifrice containing 2% CPP-ACP plus 1100 ppm F was superior to all other formulations.

scholarly journals Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

2013 ◽  
Vol 32 (4) ◽  
pp. 648-653 ◽  
Author(s):  
Rathapong THEPYOU ◽  
Wanvipa CHANMITKUL ◽  
Ornnicha THANATVARAKORN ◽  
Hidenori HAMBA ◽  
Wanwalai CHOB-ISARA ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Glass Ionomer ◽  
Caries Lesion ◽  
Casein Phosphopeptide

Casein Phosphopeptide-Amorphous Calcium Phosphate Incorporated into Sugar Confections Inhibits the Progression of Enamel Subsurface Lesions in situ

2010 ◽  
Vol 44 (1) ◽  
pp. 33-40 ◽  
Author(s):  
G.D. Walker ◽  
F. Cai ◽  
P. Shen ◽  
G.G. Adams ◽  
C. Reynolds ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Casein Phosphopeptide

scholarly journals Enamel Hardness Differences After Topical Application Of Theobromine Gel And Casein Phosphopeptide-Amorphous Calcium Phosphate

2020 ◽  
Vol 10 (1) ◽  
pp. 5
Author(s):  
Tamara Yuanita ◽  
Nanik Zubaidah ◽  
Mifta Izha A R
Keyword(s):  
Citric Acid ◽  
Calcium Phosphate ◽  
Topical Application ◽  
Amorphous Calcium Phosphate ◽  
Acrylic Resin ◽  
Control Group ◽  
Tooth Erosion ◽  
Hardness Tester ◽  
Group I ◽  
Casein Phosphopeptide

Background: Most soft drinks contain citric acid / phosphoric acid with pH <3.5. Strong acids in the oral cavity cause tooth erosion. Tooth erosion leads to demineralization enamel. Remineralization can prevent demineralization process. One of the commercial remineralization agents is Casein Phosphopeptide-amorphous Calcium Phosphate(CPP-ACP) but it has low solubility and less affordable price. Therefore, a natural ingredients such as theobromine from cocoa extract need to be developed as remineralization agent. Objective: To determine enamel hardness differences due to topical application of theobromine gel and CPP-ACP. Method: incisive crowns were cut off (1x1) cm then planted in cylindrical acrylic resin. All samples were immersed with citric acid for 90 minutes then divided into 3 groups. Group I (control) was immersed with aquades (96 min), group II was applied with theobromin gel 200 mg/l (96 min), group III was applied with CPP-ACP (96 min). By using vickers hardness tester, enamel hardness be measured (15 sec) at 3 points. Results: There were significant differences between the control group, CPP-ACP group, and theobromine gel group. Conclusion: Enamel hardnesse with theobromine gel application is higher than CPP-ACP application..

scholarly journals Efficacy of casein derivate CPP-ACP1

2014 ◽  
Vol 62 (3) ◽  
pp. 243-252
Author(s):  
Renata Faria PEREIRA ◽  
Soraya Coelho LEAL
Keyword(s):  
Calcium Phosphate ◽  
Randomized Controlled Trials ◽  
Systematic Reviews ◽  
Amorphous Calcium Phosphate ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Pubmed Database ◽  
Casein Phosphopeptide

OBJECTIVE: A literature review of systematic reviews and in situ and in vivo randomized controlled trials was conducted in order to assess the role of casein phosphopeptide - amorphous calcium phosphate in providing caries-preventive effect superior to any intervention or placebo. METHODS: Initially, Pubmed database was searched for systematic reviews. Two systematic reviews were identified, which concluded that the quantity and quality of randomized controlled trials were insufficient to recommend the clinical use of the product. After this, Pubmed database was searched for in situ and in vivo randomized controlled trials that were not included in the reviews identified. In vivo and in situ studies yielded mixed results. RESULTS: In situ studies indicated greater efficacy of casein phosphopeptide - amorphous calcium phosphate in comparison with placebo. Whereas, in vivo studies demonstrated different findings CONCLUSION: Casein phosphopeptide - amorphous calcium phosphate had a performance equivalent to or greater efficacy than placebo; fluoride was more effective than the casein complex; casein phosphopeptide - amorphous calcium phosphate associated with fluoride showed better or equivalent performance to that of placebo. In view of available evidence, it was not possible to generalize the indication of casein phosphopeptide - amorphous calcium phosphate for preventing dental caries. Further studies on the preventive effect and longer treatment applications are recommended.

scholarly journals The effect of two types chewing gum containing casein phosphopeptide-amorphous calcium phosphate and xylitol on salivary Streptococcus mutans

2015 ◽  
Vol 18 (3) ◽  
pp. 192 ◽  
Author(s):  
Shila Emamieh ◽  
Yosra Khaterizadeh ◽  
Hossein Goudarzi ◽  
Amir Ghasemi ◽  
AlirezaAkbarzadeh Baghban ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Streptococcus Mutans ◽  
Amorphous Calcium Phosphate ◽  
Chewing Gum ◽  
Casein Phosphopeptide

scholarly journals Effect of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums, and Probiotic Yogurt on Periodontal Parameters: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Maryam Mehrabkhani ◽  
Iman Parisay ◽  
Niayesh Mastoory ◽  
Vajihe Barati Doghai
Keyword(s):  
Clinical Trial ◽  
Calcium Phosphate ◽  
Randomized Clinical Trial ◽  
Amorphous Calcium Phosphate ◽  
Dental Students ◽  
Chewing Gum ◽  
Probiotic Yogurt ◽  
Chewing Gums ◽  
Casein Phosphopeptide ◽  
Non Parametric

Objectives: This study aimed to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) and xylitol chewing gums, and probiotic yogurt, as chemical plaque control strategies, on periodontal parameters. Materials and Methods: This randomized clinical trial evaluated 120 eligible dental students that were randomly divided into four groups (n=30) for use of (I) CPP-ACP chewing gum, (II) xylitol chewing gum, (III) probiotic yogurt, and (IV) chlorhexidine (CHX) mouthwash. The oral hygiene index-simplified (OHI-S), Silness and Loe gingival index (GI), and Silness and Loe modified plaque index (PI) were measured before and on days 15 and 30 after using the products. Paired t-test or its non-parametric equivalent was used to analyze the parameters after the intervention compared with baseline. The study groups were compared using one-way ANOVA or its non-parametric equivalent. Results: The OHI-S did not change over time, and most participants had a good OHI-S. The CHX group had the most favorable, and the probiotic yogurt group had the least favorable GI. Pairwise comparisons of the groups did not reveal a significant difference in GI between the CPP-ACP gum and CHX groups (P>0.05). CHX caused the greatest improvement in PI, with significant differences with other groups. Conclusion: CHX was the most effective for improvement of periodontal parameters followed by CPP-ACP, which showed better results compared with other groups.

scholarly journals THE EFFECT OF CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE-PROPOLIS CHEWING GUM ON CALCIUM AND PHOSPHATE ION LEVELS IN CARIES-FREE SUBJECT’S SALIVA AND STREPTOCOCCUS MUTANS BIOFILM FORMATION

2017 ◽  
Vol 10 (17) ◽  
pp. 174
Author(s):  
Sri Angky Soekanto ◽  
Gadiacanaparimita Ghrena Duhita ◽  
Endang Winiati Bachtiar ◽  
Muhamad Sahlan
Keyword(s):  
Calcium Phosphate ◽  
Streptococcus Mutans ◽  
Calcium Ions ◽  
Amorphous Calcium Phosphate ◽  
Chewing Gum ◽  
Phosphate Ion ◽  
Phosphate Ions ◽  
Casein Phosphopeptide ◽  
Mass Formation

 Objective: The aim of this study is to analyze the amount of calcium and phosphate ion released by casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), which supports the remineralization and the effectiveness of propolis wax in suppressing the mass formation of Streptococcus mutans biofilm on caries-free subjects and to observe if these two active components are effective when combined into one substance and placed inside sugar-free chewing gum.Methods: Twenty-five samples of caries-free saliva before and after the mastication simulation (five concentrations of chewing gum) in vitro were observed to check for release of calcium and phosphate ions along with a biofilm assay. The release of calcium ions was detected using AAS, the release of phosphate ions was detected using spectrophotometry ultraviolet-visible, and the biofilm assay was detected using a crystal violet 96-well plate ELISA and was evaluated with an ELISA reader.Result: Chewing gum with a concentration of 0% prop + 5% CPP-ACP showed the highest release level of calcium ions (p<0.05) and phosphate ions (p>0.05) and is significant in suppressing the mass formation of the S. mutans biofilm (p<0.05).Conclusions: Mastication simulation of CPP-ACP-Propolis chewing gum can increase calcium and phosphate ion levels in caries-free saliva and decrease S. mutans biofilm mass formation; this can support remineralization and becomes a dental caries prevention alternative.

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