Age-Related Changes in Water and Crystallin Content of the Fetal and Adult Human Lens, Demonstrated by a Microsectioning Technique

1987 ◽  
Vol 19 (4) ◽  
pp. 235-239 ◽  
Author(s):  
J. Bours ◽  
H.J. Födisch ◽  
O. Hockwin
Keyword(s):  
Human Lens ◽  
Adult Human ◽  
Age Related ◽  
Age Related Changes

scholarly journals Nanoceria Prevents Glucose-Induced Protein Glycation in Eye Lens Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1473
Author(s):  
Belal I. Hanafy ◽  
Gareth W. V. Cave ◽  
Yvonne Barnett ◽  
Barbara K. Pierscionek
Keyword(s):  
Protein Glycation ◽  
Human Lens ◽  
Lens Epithelial Cells ◽  
Oxide Nanoparticles ◽  
Lens Protein ◽  
Oxygen Species ◽  
Human Lens Epithelial Cells ◽  
Age Related ◽  
Age Related Changes

Cerium oxide nanoparticles (nanoceria) are generally known for their recyclable antioxidative properties making them an appealing biomaterial for protecting against physiological and pathological age-related changes that are caused by reactive oxygen species (ROS). Cataract is one such pathology that has been associated with oxidation and glycation of the lens proteins (crystallins) leading to aggregation and opacification. A novel coated nanoceria formulation has been previously shown to enter the human lens epithelial cells (HLECs) and protect them from oxidative stress induced by hydrogen peroxide (H2O2). In this work, the mechanism of nanoceria uptake in HLECs is studied and multiple anti-cataractogenic properties are assessed in vitro. Our results show that the nanoceria provide multiple beneficial actions to delay cataract progression by (1) acting as a catalase mimetic in cells with inhibited catalase, (2) improving reduced to oxidised glutathione ratio (GSH/GSSG) in HLECs, and (3) inhibiting the non-enzymatic glucose-induced glycation of the chaperone lens protein α-crystallin. Given the multifactorial nature of cataract progression, the varied actions of nanoceria render them promising candidates for potential non-surgical therapeutic treatment.

Age-Related Changes in Human Lens Crystallins Identified by HPLC and Mass Spectrometry

1998 ◽  
Vol 67 (1) ◽  
pp. 21-30 ◽  
Author(s):  
ZHIXIANG MA ◽  
STACY R.A. HANSON ◽  
KIRSTEN J. LAMPI ◽  
LARRY L. DAVID ◽  
DAVID L. SMITH ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Human Lens ◽  
Lens Crystallins ◽  
Age Related ◽  
Age Related Changes

Age-related changes of alpha-crystallin aggregate in human lens

Amino Acids ◽  
2006 ◽  
Vol 32 (1) ◽  
pp. 87-94 ◽  
Author(s):  
N. Fujii ◽  
Y. Shimmyo ◽  
M. Sakai ◽  
Y. Sadakane ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Human Lens ◽  
Alpha Crystallin ◽  
Age Related ◽  
Age Related Changes

Age-Related Changes of Human Lens Epithelial Cells in vivo

2001 ◽  
Vol 33 (6) ◽  
pp. 363-366 ◽  
Author(s):  
Hideaki Oharazawa ◽  
Nobuhiro Ibaraki ◽  
Hironori Matsui ◽  
Kunitoshi Ohara
Keyword(s):  
Epithelial Cells ◽  
Human Lens ◽  
Lens Epithelial Cells ◽  
Human Lens Epithelial Cells ◽  
Age Related ◽  
Age Related Changes

Age-related changes of anisotropic properties of water self-diffusion in human lens: Diffusion anisotropy in lens with aging

2001 ◽  
Vol 21 (1) ◽  
pp. 89-95
Author(s):  
I. V. Nesmelova ◽  
D. Sh. Idiyatullin ◽  
Z. G. Kamalov ◽  
V. D. Fedotov ◽  
K. H. Mayo
Keyword(s):  
Human Lens ◽  
Diffusion Anisotropy ◽  
Anisotropic Properties ◽  
Self Diffusion ◽  
Age Related ◽  
Age Related Changes

AGE-RELATED CHANGES IN THE HUMAN LENS AS MONITORED BY DETECTION OF PORPHYRIN EXCITED STATES

1995 ◽  
Vol 62 (2) ◽  
pp. 339-341 ◽  
Author(s):  
Joan E. Roberts ◽  
Stephen J. Atherton ◽  
Elizabeth R. Gaillard ◽  
James Dillon
Keyword(s):  
Excited States ◽  
Human Lens ◽  
Age Related ◽  
Age Related Changes

Age-Related Changes in the Lateral Lipid Distribution in a Human Lens Described by Mass Spectrometry Imaging

2015 ◽  
Vol 21 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Jaroslav Pol ◽  
Helena Faltyskova ◽  
Lukas Krasny ◽  
Michael Volný ◽  
Ondrej Vlacil ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Human Lens ◽  
Lipid Distribution ◽  
Age Related ◽  
Age Related Changes
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