Comparative Study of Triamcinolone Acetonide and Hydrocortisone 17-Butyrate in Rosacea with Special Regard to the Rebound Phenomenon

Dermatology ◽  
1976 ◽  
Vol 152 (1) ◽  
pp. 239-246 ◽  
Author(s):  
M.J.Th.H. Go ◽  
J. Wuite
Keyword(s):  
Comparative Study ◽  
Triamcinolone Acetonide ◽  
Special Regard ◽  
Rebound Phenomenon

Rebound of aldosterone but not of corticosterone after suppression of adrenal function by triamcinolone acetonide in rats

1988 ◽  
Vol 75 (5) ◽  
pp. 551-557 ◽  
Author(s):  
Gabriele Meier
Keyword(s):  
Triamcinolone Acetonide ◽  
Renal Excretion ◽  
Statistical Significance ◽  
Plasma Aldosterone ◽  
Adrenal Function ◽  
Sensitive Period ◽  
Blood Levels ◽  
Corticoid Therapy ◽  
Rebound Phenomenon

1. The effects of microcrystalline ‘depot’ triamcinolone acetonide on renal excretion and blood levels of aldosterone, 18-hydroxycorticosterone and corticosterone were studied in rats over a 13 day period. The renal excretion of all of these steroids was found to be suppressed on day 1 after triamcinolone acetonide administration. Corticosterone excretion remained suppressed for 6 days, whereas aldosterone and 18-hydroxycorticosterone excretion normalized within 3 days. 2. While corticosterone excretion was returning to control values, the excretion of aldosterone rose to values above the pretreatment levels (the rebound phenomenon). 18-Hydroxycorticosterone excretion paralleled that of aldosterone, but the rebound was of less statistical significance. 3. The findings in urine were confirmed by plasma steroid determinations. A suppression of plasma aldosterone, 18-hydroxycorticosterone and corticosterone was observed in the first 24 h after triamcinolone acetonide injection. On day 4 only corticosterone showed lowered levels. An aldosterone rebound could be seen at 18.00 hours, the circadian maximum in rats. 4. These findings suggest that in addition to the effects on glucocorticoids, mineralocorticoids have to be taken into account in the restoration of the adrenal function after corticoid therapy. The aldosterone rebound observed during this sensitive period may be important in preventing disturbances of electrolyte and water homoeostasis.

A comparative study of topical tacrolimus and topical triamcinolone acetonide in nodular scabies

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Mukesh Manjhi ◽  
Pravesh Yadav ◽  
Sneha Mohan ◽  
Sidharth Sonthalia ◽  
V. Ramesh ◽  
...  
Keyword(s):  
Comparative Study ◽  
Triamcinolone Acetonide ◽  
Topical Tacrolimus
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