A comparative study of topical tacrolimus and topical triamcinolone acetonide in nodular scabies

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Mukesh Manjhi ◽  
Pravesh Yadav ◽  
Sneha Mohan ◽  
Sidharth Sonthalia ◽  
V. Ramesh ◽  
...  
Keyword(s):  
Comparative Study ◽  
Triamcinolone Acetonide ◽  
Topical Tacrolimus

scholarly journals A comparative study of fractional carbon dioxide laser, narrowband ultraviolet B and topical tacrolimus 0.1% ointment versus narrowband ultraviolet B, topical tacrolimus 0.1% ointment in stable vitiligo

2020 ◽  
Vol 6 (2) ◽  
pp. 243
Author(s):  
Anusha Putta ◽  
Mohammed Waseem Javed
Keyword(s):  
Comparative Study ◽  
Carbon Dioxide Laser ◽  
Laser System ◽  
Treatment Protocol ◽  
Drug Efficacy ◽  
Ultraviolet B ◽  
Topical Tacrolimus ◽  
Recent Advancement ◽  
Fractional Carbon Dioxide Laser ◽  
Destruction Of Melanocytes

<p class="abstract"><strong>Background:</strong> Vitiligo, an acquired pigmentary disorder of skin and mucous membrane characterized by well circumscribed depigmented macules that occur secondary to selective destruction of melanocytes. Fractional CO<sub>2</sub> laser system is a recent advancement in the treatment of vitiligo which works on the concept of fractional photo-thermolysis, in which microscopic treatment zones are created which help in increasing the penetration of topically applied agent which indirectly improves drug efficacy.</p><p class="abstract"><strong>Methods:</strong> A comparative study was conducted on 40 patients of stable vitiligo attending OPD, Dept of DVL with fractional CO<sub>2</sub> laser, narrowband ultraviolet B (NBUVB) and topical tacrolimus 0.1% vs NBUVB, topical tacrolimus 0.1% for a duration of 4 months and patients were followed up for 12 weeks post treatment.<strong></strong></p><p class="abstract"><strong>Results:</strong> Patients on Fractional CO<sub>2</sub> laser in combination with NBUVB and topical tacrolimus 0.1% ointment showed &gt;50% improvement compared with other group, with duration for initiation of pigmentation being comparatively less.</p><p class="abstract"><strong>Conclusions:</strong> The treatment protocol with CO<sub>2</sub> laser in combination with topical tacrolimus 0.1% cream and NBUVB for stable vitiligo was more effective than NBUVB and topical tacrolimus 0.1% alone and this study demonstrates that adding fractional CO<sub>2</sub> laser improves repigmentation rate of vitiliginous lesions.</p>

scholarly journals COMPARATIVE STUDY OF EFFICACY AND SAFETY OF INTRALESIONAL TRIAMCINOLONE ACETONIDE VERSUS INTRALESIONAL 5-FLUOROURACIL VERSUS COMBINATION OF BOTH IN MANAGEMENT OF KELOIDS

2019 ◽  
pp. 1-3
Author(s):  
Himani Tandon ◽  
Anuj Kumar ◽  
P. K. Rathore
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Triamcinolone Acetonide ◽  
The Other ◽  
Efficacy And Safety ◽  
Mild Pain

BACKGROUND: keloid is a benign overgrowth of brotic tissue and are aesthetically unacceptable to the patients. Management is difcult and pose a challenge for physicians. This study compares the efcacy and safety of intralesional triamcinolone acetonide, intralesional 5-uorouracil and combination of both in management of keloids. METHOD: Total 60 patients, randomly divided into three groups: A, B, C were subjected to intralesional Triamcinolone acetonide, 5- Fluorouracil and their combination respectively, every 3weeks for 18 weeks and assessed with Vancouver Scoring Scale. RESULTS:Improvement seen in all parameters, maximum with combination of triamcinolone and 5-uorouracil. Major side effects were hypopigmentation with intralesional triamcinolone; pain and hyperpigmentation with intralesional 5- uorouracil and mild pain with combination of two. CONCLUSION: Combination of 5-uorouracil and triamcinolone acetonide seemed to be more effective with lesser side effects than the other two.

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