Operability of Fortner’s Hamster Melanoma AMel 3

Dermatology ◽  
1972 ◽  
Vol 144 (2) ◽  
pp. 92-96 ◽  
Author(s):  
E. Haneke ◽  
W. Wohlrab ◽  
J. Peker
Keyword(s):  
Hamster Melanoma

Regression of Hamster Melanoma by Corynebacterium parvum

1975 ◽  
pp. 276-283
Author(s):  
Nikolai V. Dimitrov ◽  
Ivan Chouroulinkov ◽  
Lucien Israel ◽  
John J. O’Rangers
Keyword(s):  
Corynebacterium Parvum ◽  
Hamster Melanoma

Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa

1988 ◽  
Vol 89 (3) ◽  
pp. 287-296
Author(s):  
A. Slominski ◽  
G. Moellmann ◽  
E. Kuklinska ◽  
A. Bomirski ◽  
J. Pawelek
Keyword(s):  
Large Scale ◽  
Positive Control ◽  
Tyrosinase Activity ◽  
Pigment Cells ◽  
Positive Regulation ◽  
Melanin Pigmentation ◽  
Subcellular Organelles ◽  
Rate Limiting ◽  
Tyrosine D ◽  
Hamster Melanoma

We describe results demonstrating the positive regulation of melanogenesis by two substrates of the melanogenic pathway. We have found that L-tyrosine and L-dihydroxyphenylalanine (L-dopa), whose metabolic fates are affected by the activity of that pathway, can also act as its regulators. In living pigment cells, tyrosinase (EC 1.14.18.1), a crucial and rate-limiting enzyme of melanogenesis, acts in subcellular organelles known as melanosomes. Melanin is laid down only in these organelles. We demonstrate that supplementing Ham's F-10 medium with additional L-tyrosine or L-dopa during the culture of amelanotic Bomirski hamster melanoma cells results in a rapid increase in melanin formation, which is not simply due to greater availability of substrate. There is a rapid increase in tyrosinase activity and a large scale synthesis of melanosomes. The effects of L-tyrosine and L-dopa are prevented by the addition of cycloheximide. The actions of L-tyrosine and L-dopa are specific in that under similar conditions D-tyrosine, D-dopa, N-acetyl-L-tyrosine, L-phenylalanine, L-tryptophan and L-valine have little or no effect. The two substrates, L-tyrosine and L-dopa, appear to act through related but distinct mechanisms. Our findings provide an example of a little-known phenomenon: regulation of a differentiated eukaryotic phenotype through positive control by substrates in the pathway.

DOPA decarboxylase activity in a transplantable hamster melanoma

1965 ◽  
Vol 21 (5) ◽  
pp. 265-266 ◽  
Author(s):  
R. Håkanson ◽  
H. Möller ◽  
N. G. Stormby
Keyword(s):  
Dopa Decarboxylase ◽  
Decarboxylase Activity ◽  
Hamster Melanoma

Pathology and Ultrastructural Characteristics of a Hypomelanotic Variant of Transplantable Hamster Melanoma With Elevated Tyrosinase Activity

1987 ◽  
Vol 89 (5) ◽  
pp. 469-473 ◽  
Author(s):  
Andrzej Bomirski ◽  
Teresa Wrzolkowa ◽  
Maria Arendarczyk ◽  
Marta Bomirska ◽  
Elizabeth Kuklinska ◽  
...  
Keyword(s):  
Tyrosinase Activity ◽  
Ultrastructural Characteristics ◽  
Hamster Melanoma

Evidence for Proflavine Sensitive Proteins in Malignant Hamster Melanoma

1971 ◽  
Vol 352 (1) ◽  
pp. 780-790 ◽  
Author(s):  
GEORG D. BIRKMAYER ◽  
BERND-RÜDIGER BALDA
Keyword(s):  
Hamster Melanoma
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