Oral Activity of 1-β-d-Arabinofuranosylcytosine in a Transplantable Hamster Melanoma

Chemotherapy ◽  
1971 ◽  
Vol 16 (5) ◽  
pp. 294-299 ◽  
Author(s):  
D.M. Goldenberg
Keyword(s):  
Oral Activity ◽  
Hamster Melanoma

Regression of Hamster Melanoma by Corynebacterium parvum

1975 ◽  
pp. 276-283
Author(s):  
Nikolai V. Dimitrov ◽  
Ivan Chouroulinkov ◽  
Lucien Israel ◽  
John J. O’Rangers
Keyword(s):  
Corynebacterium Parvum ◽  
Hamster Melanoma

scholarly journals PENGEMBANGAN KREATIVITAS SISWA DALAM PEMBELAJARAN DI MI MA’ARIF NU 01 PAGERAJI KECAMATAN CILONGOK KABUPATEN BANYUMAS

2015 ◽  
Vol 16 (1) ◽  
pp. 120-130
Author(s):  
Abu Dharin
Keyword(s):  
Motor Activity ◽  
Instructional Media ◽  
Environment Design ◽  
Student Activity ◽  
Creativity Development ◽  
Oral Activity

Abstract: The results showed that: The efforts that teachers in developing students' creativity in the leaming process are: a) Giving full freedom to students in leaming, for example, provide an opportunity to ask questions, ideas and suggestions; b) Creating a leaming atmosphere that is comfortable and pleasant, c) Teacher appearances are democratic, friendly, patient, fair, consistent, flexible, cheerful, humorous, intimate, and always pay attention to all students; d) The teacheralways motivate students to be active in leaming and help them with leaming difficulties; e) Teachers often use a variety of leaming methods so that students are not saturated in the leaming process. f) Teachers use a variety of instructional media that is easy to understand the material presented and the students can visually stimulate students. 2) Teachers also try to create a conducive leaming environment design so that the leaming process can run effectively and efficiently. 3) In the process of leaming that support the creativity of the students do various activities, namely: motor activity, oral activity, the activity of listening, and writing activities. The student activity varied use is that the students are not saturated in leaning activities. Keywords: Creativity Development, Learning  

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity

2001 ◽  
Vol 11 (21) ◽  
pp. 2867-2870 ◽  
Author(s):  
Jerry L. Adams ◽  
Jeffrey C. Boehm ◽  
Timothy F. Gallagher ◽  
Shouki Kassis ◽  
Edward F. Webb ◽  
...  
Keyword(s):  
P38 Kinase ◽  
Kinase Inhibition ◽  
Oral Activity

scholarly journals Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Biomedicines ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 90 ◽  
Author(s):  
Volker Herzig ◽  
Aline de Araujo ◽  
Kathryn Greenwood ◽  
Yanni Chin ◽  
Monique Windley ◽  
...  
Keyword(s):  
Oral Toxicity ◽  
Peptide Backbone ◽  
Insect Midgut ◽  
Peptide Toxins ◽  
Oral Activity ◽  
The Stability ◽  
Reduced Rate ◽  
Chemical Strategies ◽  
Orally Active ◽  
Insecticidal Peptides

Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity. We therefore systematically evaluated several synthetic strategies to increase the stability and oral potency of the potent insecticidal spider-venom peptide ω-HXTX-Hv1a (Hv1a). Selective chemical replacement of disulfide bridges with diselenide bonds and N- to C-terminal cyclization were anticipated to improve Hv1a resistance to proteolytic digestion, and thereby its activity when delivered orally. We found that native Hv1a is orally active in blowflies, but 91-fold less potent than when administered by injection. Introduction of a single diselenide bond had no effect on the susceptibility to scrambling or the oral activity of Hv1a. N- to C-terminal cyclization of the peptide backbone did not significantly improve the potency of Hv1a when injected into blowflies and it led to a significant decrease in oral activity. We show that this is likely due to a dramatically reduced rate of translocation of cyclic Hv1a across the insect midgut, highlighting the importance of testing bioavailability in addition to toxin stability.

Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa

1988 ◽  
Vol 89 (3) ◽  
pp. 287-296
Author(s):  
A. Slominski ◽  
G. Moellmann ◽  
E. Kuklinska ◽  
A. Bomirski ◽  
J. Pawelek
Keyword(s):  
Large Scale ◽  
Positive Control ◽  
Tyrosinase Activity ◽  
Pigment Cells ◽  
Positive Regulation ◽  
Melanin Pigmentation ◽  
Subcellular Organelles ◽  
Rate Limiting ◽  
Tyrosine D ◽  
Hamster Melanoma

We describe results demonstrating the positive regulation of melanogenesis by two substrates of the melanogenic pathway. We have found that L-tyrosine and L-dihydroxyphenylalanine (L-dopa), whose metabolic fates are affected by the activity of that pathway, can also act as its regulators. In living pigment cells, tyrosinase (EC 1.14.18.1), a crucial and rate-limiting enzyme of melanogenesis, acts in subcellular organelles known as melanosomes. Melanin is laid down only in these organelles. We demonstrate that supplementing Ham's F-10 medium with additional L-tyrosine or L-dopa during the culture of amelanotic Bomirski hamster melanoma cells results in a rapid increase in melanin formation, which is not simply due to greater availability of substrate. There is a rapid increase in tyrosinase activity and a large scale synthesis of melanosomes. The effects of L-tyrosine and L-dopa are prevented by the addition of cycloheximide. The actions of L-tyrosine and L-dopa are specific in that under similar conditions D-tyrosine, D-dopa, N-acetyl-L-tyrosine, L-phenylalanine, L-tryptophan and L-valine have little or no effect. The two substrates, L-tyrosine and L-dopa, appear to act through related but distinct mechanisms. Our findings provide an example of a little-known phenomenon: regulation of a differentiated eukaryotic phenotype through positive control by substrates in the pathway.

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