DOPA decarboxylase activity in a transplantable hamster melanoma

1965 ◽  
Vol 21 (5) ◽  
pp. 265-266 ◽  
Author(s):  
R. Håkanson ◽  
H. Möller ◽  
N. G. Stormby
Keyword(s):  
Dopa Decarboxylase ◽  
Decarboxylase Activity ◽  
Hamster Melanoma

scholarly journals Dopa-decarboxylase activity and 5-HTP decarboxylase activity in pregnant rats

1990 ◽  
Vol 52 ◽  
pp. 231
Author(s):  
Naova HAMAUE ◽  
Toru ENDO ◽  
Akiyoshi YANAI ◽  
Yasuteru SHIROSHITA ◽  
Yoshio MONMA ◽  
...  
Keyword(s):  
Dopa Decarboxylase ◽  
Decarboxylase Activity ◽  
Pregnant Rats

scholarly journals Dopa decarboxylase activity of the living human brain.

1991 ◽  
Vol 88 (7) ◽  
pp. 2721-2725 ◽  
Author(s):  
A. Gjedde ◽  
J. Reith ◽  
S. Dyve ◽  
G. Leger ◽  
M. Guttman ◽  
...  
Keyword(s):  
Human Brain ◽  
Dopa Decarboxylase ◽  
Decarboxylase Activity

scholarly journals Dopa-decarboxylase activity and plasma prolactin concentration in rats

1989 ◽  
Vol 49 ◽  
pp. 186
Author(s):  
Naoya Hamaue ◽  
Hiroyuki Sato ◽  
Haruko Kameda ◽  
Yoshio Monma ◽  
Masaru Minami ◽  
...  
Keyword(s):  
Dopa Decarboxylase ◽  
Decarboxylase Activity ◽  
Plasma Prolactin

scholarly journals Plasma dopa decarboxylase activity in treatment-resistant recent-onset psychosis patients

2019 ◽  
Vol 9 ◽  
pp. 204512531987234
Author(s):  
Marieke van der Pluijm ◽  
Arjen L. Sutterland ◽  
André B. P. van Kuilenburg ◽  
Lida Zoetekouw ◽  
Lieuwe de Haan ◽  
...  
Keyword(s):  
Surrogate Marker ◽  
Clinical Problem ◽  
Dopa Decarboxylase ◽  
Antipsychotic Treatment ◽  
Decarboxylase Activity ◽  
Treatment Resistant ◽  
Significant Group ◽  
Adequate Treatment ◽  
Recent Onset ◽  
Potential Biomarker

Treatment resistance (TR) in psychosis is a major clinical problem. A biomarker predicting TR against conventional antipsychotic drugs would be relevant, potentially reducing unnecessary delay to adequate treatment with clozapine. Dopa decarboxylase (DDC) activity in the striatum, measured with positron emission tomography, is elevated in responders, but not in treatment-resistant patients. Plasma DDC activity could be a surrogate marker for DDC brain activity, and thus a potential biomarker that could be used in daily clinical practice. Therefore, we determined plasma DDC activity in 40 male patients with recent-onset psychosis, of whom the majority had started treatment, whereby 21 turned out to be treatment responders and 19 treatment resistant during follow up. We observed no significant group differences. Furthermore, symptom severity was not associated with plasma DCC activity. We did observe a trend level difference in the distribution of plasma DDC activity across categories of medication, with subsequent post hoc analysis showing lower DDC activity in risperidone-using patients. This may suggest that risperidone could influence plasma DDC activity. Based on these results, plasma DDC activity does not appear to be a promising biomarker for TR in recent-onset psychosis patients who are already receiving antipsychotic treatment.

Elevated caudate DOPA decarboxylase activity in vivo in schizophrenia and temporal lobe epilepsy with psychosis

1991 ◽  
Vol 1 (3) ◽  
pp. 472 ◽  
Author(s):  
J Reith ◽  
C Benkelfat ◽  
H Kuwabara ◽  
G Savard ◽  
G Chouinard ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Dopa Decarboxylase ◽  
Decarboxylase Activity

Dopa-decarboxylase activity and 5-HTP decarboxylase activity during rat pregnancy

1990 ◽  
Vol 183 (4) ◽  
pp. 1372
Author(s):  
N. Hamaue ◽  
M. Minami ◽  
T. Endo ◽  
A. Yanai ◽  
H. Matsuda ◽  
...  
Keyword(s):  
Dopa Decarboxylase ◽  
Decarboxylase Activity

Temporal and spatial expression of the yellow gene in correlation with cuticle formation and DOPA decarboxylase activity in drosophila development

1991 ◽  
Vol 147 (1) ◽  
pp. 32-45 ◽  
Author(s):  
Marika F. Walter ◽  
Bruce C. Black ◽  
Golnar Afshar ◽  
Anne-Yvonne Kermabon ◽  
Theodore R.F. Wright ◽  
...  
Keyword(s):  
Yellow Gene ◽  
Dopa Decarboxylase ◽  
Decarboxylase Activity ◽  
Drosophila Development ◽  
Spatial Expression ◽  
Cuticle Formation ◽  
Temporal And Spatial

scholarly journals Quantitative [18F]Fluorodopa/PET and Histology of Fetal Mesencephalic Dopaminergic Grafts to the Striatum of MPTP-Poisoned Minipigs

2002 ◽  
Vol 11 (8) ◽  
pp. 733-746 ◽  
Author(s):  
Annette Møller Dall ◽  
Erik Hvid Danielsen ◽  
Jens Christian Sørensen ◽  
Flemming Andersen ◽  
Arne Møller ◽  
...  
Keyword(s):  
Immunosuppressive Treatment ◽  
Motor Impairment ◽  
Relative Activity ◽  
Functional Restoration ◽  
Dopa Decarboxylase ◽  
Control Group ◽  
Neural Cells ◽  
Decarboxylase Activity ◽  
Dopamine Innervation ◽  
Fetal Pig

The functional restoration of the dopamine innervation of striatum in MPTP-poisoned Göttingen minipigs was assessed for 6 months following grafting of fetal pig mesencephalic neurons. Pigs were assigned to a normal control group and a MPTP-poisoned group, members of which received no further treatment, or which received bilateral grafts to the striatum of tissue blocks harvested from E28 fetal pig mesencephalon with and without immunosuppressive treatment after grafting, or with additional co-grafting with immortalized rat neural cells transfected to produce GDNF. In the baseline condition, and again at 3 and 6 months postsurgery, all animals were subjected to quantitative [18F]fluorodopa PET scans and testing for motor impairment. At the end of 6 months, tyrosine hydroxylase (TH)-containing neurons were counted in the grafts by stereological methods. The MPTP poisoning persistently reduced the magnitude of k3D, the relative activity of DOPA decarboxylase in striatum, by 60%. Grafting restored the rate of [18F]fluorodopa decarboxylation to the normal range, and normalized the scores in motor function. The biochemical and functional recovery was associated with survival of approximately 100,000 TH-positive graft neurons in each hemisphere. Immunosuppression did not impart a greater recovery of [18F]fluorodopa uptake, nor were the number of TH-positive graft neurons or the volumes of the grafts increased in the immunosuppressed group. Contrary to expectation, co-grafting of transfected GDNF-expressing HiB5 cells, a rat-derived neural cell line, tended to impair the survival of the grafts with the lowest values for graft volumes, TH-positive cell numbers, behavioral scores, and relative DOPA decarboxylase activity. From the results we conclude that pig ventral mesencephalic allografts can restore functional dopamine innervation in adult MPTP-lesioned minipigs.

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