Cooperation between Transcription Factors Regulates Liver Development

Neonatology ◽  
1995 ◽  
Vol 67 (6) ◽  
pp. 387-396 ◽  
Author(s):  
Adi Aran ◽  
Hanoch Cassuto ◽  
Lea Reshef
Keyword(s):  
Transcription Factors ◽  
Liver Development

scholarly journals Liver-enriched transcription factors regulate MicroRNA-122 that targets CUTL1 during liver development

Hepatology ◽  
2010 ◽  
Vol 52 (4) ◽  
pp. 1431-1442 ◽  
Author(s):  
Hui Xu ◽  
Jie-Hua He ◽  
Zhen-Dong Xiao ◽  
Qian-Qian Zhang ◽  
Yue-Qin Chen ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Liver Development

scholarly journals Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation

Cell Reports ◽  
2020 ◽  
Vol 30 (5) ◽  
pp. 1319-1328.e6 ◽  
Author(s):  
Panagiota Karagianni ◽  
Panagiotis Moulos ◽  
Dominic Schmidt ◽  
Duncan T. Odom ◽  
Iannis Talianidis
Keyword(s):  
Transcription Factors ◽  
Gene Activation ◽  
Liver Development

scholarly journals Transcription Control of Liver Development

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2026
Author(s):  
Evangelia C. Tachmatzidi ◽  
Ourania Galanopoulou ◽  
Iannis Talianidis
Keyword(s):  
Transcription Factors ◽  
Target Genes ◽  
Expression Profiles ◽  
Gene Activation ◽  
Condensed Chromatin ◽  
Liver Development ◽  
Transcription Control ◽  
Memory Mechanism ◽  
Hepatic Expression ◽  
Pioneer Factors

During liver organogenesis, cellular transcriptional profiles are constantly reshaped by the action of hepatic transcriptional regulators, including FoxA1-3, GATA4/6, HNF1α/β, HNF4α, HNF6, OC-2, C/EBPα/β, Hex, and Prox1. These factors are crucial for the activation of hepatic genes that, in the context of compact chromatin, cannot access their targets. The initial opening of highly condensed chromatin is executed by a special class of transcription factors known as pioneer factors. They bind and destabilize highly condensed chromatin and facilitate access to other “non-pioneer” factors. The association of target genes with pioneer and non-pioneer transcription factors takes place long before gene activation. In this way, the underlying gene regulatory regions are marked for future activation. The process is called “bookmarking”, which confers transcriptional competence on target genes. Developmental bookmarking is accompanied by a dynamic maturation process, which prepares the genomic loci for stable and efficient transcription. Stable hepatic expression profiles are maintained during development and adulthood by the constant availability of the main regulators. This is achieved by a self-sustaining regulatory network that is established by complex cross-regulatory interactions between the major regulators. This network gradually grows during liver development and provides an epigenetic memory mechanism for safeguarding the optimal expression of the regulators.

The initiation of liver development is dependent on Foxa transcription factors

Nature ◽  
2005 ◽  
Vol 435 (7044) ◽  
pp. 944-947 ◽  
Author(s):  
Catherine S. Lee ◽  
Joshua R. Friedman ◽  
James T. Fulmer ◽  
Klaus H. Kaestner
Keyword(s):  
Transcription Factors ◽  
Liver Development ◽  
Foxa Transcription Factors

scholarly journals Expression of hepatic transcription factors during liver development and oval cell differentiation.

1994 ◽  
Vol 126 (1) ◽  
pp. 223-233 ◽  
Author(s):  
P Nagy ◽  
H C Bisgaard ◽  
S S Thorgeirsson
Keyword(s):  
Cell Proliferation ◽  
Transcription Factors ◽  
Cell Activation ◽  
Liver Parenchyma ◽  
Transcriptional Factors ◽  
Liver Development ◽  
Oval Cells ◽  
Mrna Levels ◽  
Oval Cell ◽  
Adult Rat

The oval cells are thought to be the progeny of a liver stem cell compartment and strong evidence now exists indicating that these cells can participate in liver regeneration by differentiating into different hepatic lineages. To better understand the regulation of this process we have studied the expression of liver-enriched transcriptional factors (HNF1 alpha and HNF1 beta, HNF3 alpha, HNF3 beta, and HNF3 gamma, HNF4, C/EBP, C/EBP beta, and DBP) in an experimental model of oval cell proliferation and differentiation and compared the expression of these factors to that observed during late stages of hepatic ontogenesis. The steady-state mRNA levels of four (HNF1 alpha, HNF3 alpha, HNF4, and C/EBP beta) "liver-enriched" transcriptional factors gradually decrease during the late period of embryonic liver development while three factors (HNF1 beta, HNF3 beta, and DBP) increase. In the normal adult rat liver the expression of all the transcription factors are restricted to the hepatocytes. However, during early stages of oval cell proliferation both small and large bile ducts start to express HNF1 alpha and HNF1 beta, HNF3 gamma, C/EBP, and DBP but not HNF4. At the later stages all of these factors are also highly expressed in the proliferating oval cells. Expression of HNF4 is first observed when the oval cells differentiate morphologically and functionally into hepatocytes and form basophilic foci. At that time the expression of some of the other factors is also further increased. Based on these data we suggest that the upregulation of the "establishment" factors (HNF1 and -3) may be an important step in oval cell activation. The high levels of these factors in the oval cells and embryonic hepatoblasts further substantiates the similarity between the two cell compartments. Furthermore, the data suggest that HNF4 may be responsible for the final commitment of a small portion of the oval cells to differentiate into hepatocytes which form the basophilic foci and eventually regenerate the liver parenchyma.

Transcription factors in liver development, differentiation, and regeneration

Hepatology ◽  
2003 ◽  
Vol 38 (6) ◽  
pp. 1331-1347 ◽  
Author(s):  
Robert H. Costa ◽  
Vladimir V. Kalinichenko ◽  
Ai-Xuan L. Holterman ◽  
Xinhe Wang
Keyword(s):  
Transcription Factors ◽  
Liver Development
Sign in / Sign up

Export Citation Format

Share Document