The Effect of Mast Cell Chymase on Extracellular Matrix: Studies in Autoimmune Thyroiditis and in Cultured Thyroid Cells

1992 ◽  
Vol 99 (1) ◽  
pp. 141-149 ◽  
Author(s):  
K. Banovac ◽  
R. De Forteza
Keyword(s):  
Extracellular Matrix ◽  
Mast Cell ◽  
Autoimmune Thyroiditis ◽  
Thyroid Cells ◽  
Mast Cell Chymase

Effect of Mast Cell Chymase on the Morphology of Thyroid Cells in vitro

1992 ◽  
Vol 99 (1) ◽  
pp. 133-140 ◽  
Author(s):  
R. De Forteza ◽  
K. Banovac ◽  
E. Koren
Keyword(s):  
Mast Cell ◽  
Thyroid Cells ◽  
Mast Cell Chymase

Interaction of Osteoblasts with Extracellular Matrix: Effect of Mast Cell Chymase

1993 ◽  
Vol 203 (2) ◽  
pp. 221-235 ◽  
Author(s):  
K. Banovac ◽  
F. Banovac ◽  
J. Yang ◽  
E. Koren
Keyword(s):  
Extracellular Matrix ◽  
Mast Cell ◽  
Matrix Effect ◽  
Mast Cell Chymase

scholarly journals Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase: implications for HDL function

2000 ◽  
Vol 41 (6) ◽  
pp. 975-984
Author(s):  
Miriam Lee ◽  
Patrizia Uboldi ◽  
Daniela Giudice ◽  
Alberico L. Catapano ◽  
Petri T. Kovanen
Keyword(s):  
Mast Cell ◽  
Hdl Function ◽  
Mast Cell Chymase

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signaling☆

2006 ◽  
Vol 312 (8) ◽  
pp. 1289-1298 ◽  
Author(s):  
M LESKINEN ◽  
H HEIKKILA ◽  
M SPEER ◽  
J HAKALA ◽  
M LAINE ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Survival Signaling ◽  
Muscle Cell Apoptosis ◽  
Mast Cell Chymase

scholarly journals Mast Cell Adhesion to Extracellular Matrix: Local Effects of Acute Phase Reactants

1997 ◽  
Vol 113 (1-3) ◽  
pp. 295-296 ◽  
Author(s):  
Rami Hershkoviz ◽  
Liana Preciado-Patt ◽  
Ofer Lider ◽  
Mati Fridkin ◽  
Yoseph A. Mekori
Keyword(s):  
Extracellular Matrix ◽  
Mast Cell ◽  
Cell Adhesion ◽  
Acute Phase ◽  
Local Effects ◽  
Acute Phase Reactants

Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells

Allergy ◽  
2018 ◽  
Author(s):  
Xiaoying Zhou ◽  
Tao Wei ◽  
Christopher W. Cox ◽  
Andrew F. Walls ◽  
Yuan Jiang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Epithelial Cells ◽  
Bronchial Epithelium ◽  
Cell Junction ◽  
Junction Molecules ◽  
Mast Cell Chymase

scholarly journals Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

2005 ◽  
Vol 145 (4) ◽  
pp. 424-431 ◽  
Author(s):  
Naotaka Shiota ◽  
Eiichi Kakizoe ◽  
Keiko Shimoura ◽  
Tetsuya Tanaka ◽  
Hideki Okunishi
Keyword(s):  
Mast Cell ◽  
Tight Skin ◽  
Mast Cell Chymase ◽  
Chymase Inhibitor

Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice

2002 ◽  
Vol 103 (s2002) ◽  
pp. 353S-356S ◽  
Author(s):  
Benjamin A. DE CAMPO ◽  
Roy G. GOLDIE ◽  
Arco Y. JENG ◽  
Peter J. HENRY
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Response Curve ◽  
Histological Analysis ◽  
Neutral Endopeptidase ◽  
Converting Enzyme ◽  
Rightward Shift ◽  
Endothelin Converting Enzyme ◽  
Mast Cell Chymase

The present study examined the roles of endothelin-converting enzyme (ECE), neutral endopeptidase (NEP) and mast cell chymase as processors of the endothelin (ET) analogues ET-1(1–21), ET-1(1–31) and big ET-1 in the trachea of allergic mice. Male CBA/CaH mice were sensitized with ovalbumin (10µg) delivered intraperitoneal on days 1 and 14, and exposed to aerosolized ovalbumin on days 14, 25, 26 and 27 (OVA mice). Mice were killed and the trachea excised for histological analysis and contraction studies on day 28. Tracheae from OVA mice had 40% more mast cells than vehicle-sensitized mice (sham mice). Ovalbumin (10µg/ml) induced transient contractions (15±3% of the Cmax) in tracheae from OVA mice. The ECE inhibitor CGS35066 (10µM) inhibited contractions induced by big ET-1 (4.8-fold rightward shift of dose-response curve; P<0.05), but not those induced by either ET-1(1–21) or ET-1(1–31). The chymase inhibitors chymostatin (10µM) and Bowman-Birk inhibitor (10µM) had no effect on contractions induced by any of the ET analogues used. The NEP inhibitor CGS24592 (10µM) inhibited contractions induced by ET-1(1–31) (6.2-fold rightward shift; P<0.05) but not ET-1(1–21) or big ET-1. These data suggest that big ET-1 is processed predominantly by a CGS35066-sensitive ECE within allergic airways rather than by mast cell-derived proteases such as chymase. If endogenous ET-1(1–31) is formed within allergic airways, it is likely to undergo further conversion by NEP to more active products.

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