The Effect of Disodium Cromoglycate and Other Inhibitors on in vitro Anaphylactic Histamine Release from Guinea Pig Basophil Leucocytes

1969 ◽  
Vol 36 (5) ◽  
pp. 497-505 ◽  
Author(s):  
M.W. Greaves
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Disodium Cromoglycate ◽  
Anaphylactic Histamine Release

scholarly journals Selective inhibition by antiflamrnin-2 of thromboxane B2release from isolated and perfused guinea-pig lung

1992 ◽  
Vol 1 (4) ◽  
pp. 251-254
Author(s):  
Lidia Sautebin ◽  
Giuseppe Cirino ◽  
Massimo Di Rosa
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Calcium Ionophore ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Amino Acid Residues ◽  
A 23187 ◽  
Normal Lungs

Antiflammin-2 (AF2) is a nonapeptide corresponding to the amino acid residues 246–254 of lipocortin-1 showing anti-inflammatory activity both in vitro and in vivo. The effect of AF2 on the thromboxane B2(TXB2) and histamine release from isolated and perfused guinea-pig lungs has been studied. AF-2 (10–100 nM) inhibited leukotriene C4- (LTC4) (3 ng) and antigen-induced (ovalbumin, 1 mg) TXB2release in normal and sensitized lungs, respectively. In contrast AF-2 (100 nM) did not modify TXB2release induced by histamine (5 μg) or bradykinin (5 μg) in normal lungs. Antigen-induced histamine release was not affected by 100 nM AF-2 infusion. When tested in chopped lung fragments AF-2 (0.1–25 μM) did not modify the release of histamine and TXB2induced by antigen (ovalbumin, 10 μg ml−1) or calcium ionophore A 23187 (1 μM). Our results show that the inhibitory effect of AF-2 on TXB2release is selective and depends on the stimulus applied. In this respect AF-2 mimics, at least in part, the actions of both glucocorticoids and lipocortin-1.

Defibrotide decreases histamine release in a guinea-pig model of myocardial ischemia and reperfusion “in vitro”

1992 ◽  
Vol 36 (S2) ◽  
pp. C333-C335 ◽  
Author(s):  
M. Lupini ◽  
F. Gambassi ◽  
L. Mugnai ◽  
S. Bianchi ◽  
E. Masini ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Guinea Pig ◽  
Histamine Release ◽  
Pig Model ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Guinea Pig Model

Studies on the role of c-AMP in the regulation of the anaphylactic histamine release from guinea pig lung

1973 ◽  
Vol 3 (3) ◽  
pp. 192-193 ◽  
Author(s):  
W. Schmutzler ◽  
G. Poblete-Freundt ◽  
R. Derwall
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Anaphylactic Histamine Release
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