Effect of various GABA-receptor agonists and antagonists on anaphylactic histamine release in the guinea-pig ileum

1987 ◽  
Vol 20 (3-4) ◽  
pp. 181-184 ◽  
Author(s):  
S. Luzzi ◽  
S. Franchi-Micheli ◽  
M. Ciuffi ◽  
E. Rosi ◽  
L. Zilletti
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Gaba Receptor ◽  
Guinea Pig Ileum ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists ◽  
Anaphylactic Histamine Release

Peptide and non-peptide bradykinin B2 receptor agonists and antagonists: a reappraisal of their pharmacology in the guinea-pig ileum

2000 ◽  
Vol 409 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Stefania Meini ◽  
Riccardo Patacchini ◽  
Alessandro Lecci ◽  
Laura Quartara ◽  
Carlo Alberto Maggi
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Bradykinin B2 Receptor ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists

Substance P-induced histamine release in tracheally perfused guinea pig lungs

1995 ◽  
Vol 78 (4) ◽  
pp. 1234-1241 ◽  
Author(s):  
C. M. Lilly ◽  
A. E. Hall ◽  
I. W. Rodger ◽  
L. Kobzik ◽  
K. J. Haley ◽  
...  
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Guinea Pig ◽  
Histamine Release ◽  
Receptor Activation ◽  
Neurokinin A ◽  
Histamine Liberation ◽  
Nk1 Antagonist ◽  
Nk2 Receptor ◽  
Receptor Agonists And Antagonists

The capacity of substance P (SP) and endogenously released tachykinins to liberate histamine was examined in isolated tracheally perfused guinea pig lungs. Increasing doses of tracheally injected SP were associated with the recovery of increasing amounts of histamine from lung effluent. The mechanism of SP-induced histamine liberation was explored in studies with neurokinin-(NK) receptor agonists and antagonists. Tracheal injection of either the NK1 agonist [Sar9,Met(O2)11]SP or the NK2 agonist [beta-Ala8]-neurokinin A-(4–10) was associated with a significant increase in histamine recovery from lung effluent. In addition, both the NK1 antagonist CP-99994 and the NK2 antagonist SR-48968 significantly inhibited SP-induced histamine release. These findings support the hypothesis that SP can liberate histamine from guinea pigs lungs by a mechanism that depends predominantly on NK1- and NK2-receptor activation. The liberation of endogenous tachykinins by acute tracheal injection of capsaicin was also associated with augmented histamine recovery, which was inhibited by combined NK1- and NK2-receptor blockade. Tracheal injection of SP was associated with an increase in the percentage of airway mast cells exhibiting histological evidence of degranulation. This study demonstrates that exogenous SP, as well as endogenous tachykinins released from capsaicin-sensitive neurons, can liberate histamine, most likely from airway mast cells, by a mechanism that depends predominantly on the activation of NK1 and NK2 receptors.

Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice

1993 ◽  
Vol 111 (2) ◽  
pp. 134-138 ◽  
Author(s):  
Claudio Castellano ◽  
Vincenzo Cestari ◽  
Simona Cabib ◽  
Stefano Puglisi-Allegra
Keyword(s):  
Gaba Receptor ◽  
Memory Storage ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists ◽  
Strain Dependent

5-Hydroxytryptamine4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea pig ileum: Antagonism by tropisetron and DAU 6285

Life Sciences ◽  
1992 ◽  
Vol 50 (21) ◽  
pp. PL173-PL178 ◽  
Author(s):  
Marcello Tonini ◽  
Stefano M. Candura ◽  
Luciano Onori ◽  
Teresa Coccini ◽  
Luigi Manzo ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Circular Muscle ◽  
Cholinergic Transmission ◽  
Guinea Pig Ileum ◽  
Receptor Agonists
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