Chlorpromazine-induced histamine release from guinea-pig skin in vitro?A photosensitive reaction

1976 ◽  
Vol 255 (3) ◽  
pp. 219-223 ◽  
Author(s):  
Sau Kuen Lam ◽  
D. R. Tomlinson
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Pig Skin

Antigen-induced histamine release by penetration of egg albumin antigen through excised guinea pig skin

1981 ◽  
Vol 271 (3) ◽  
pp. 357-360 ◽  
Author(s):  
S. Yamamoto ◽  
I. Kimura ◽  
T. Numata ◽  
T. Yamura
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Egg Albumin ◽  
Pig Skin

scholarly journals In Vitro Anaphylaxis In Guinea-Pig Skin: Amplification By Burimamide

1976 ◽  
Vol 67 (6) ◽  
pp. 696-699 ◽  
Author(s):  
Shoso Yamamoto ◽  
David Francis ◽  
Malcolm W Greaves
Keyword(s):  
Guinea Pig ◽  
Pig Skin

Release of peptide leukotrienes(LTS) from sensitized guinea pig skin in in vitro cutaneous anaphylactic reactions

1991 ◽  
Vol 2 (3) ◽  
pp. 232
Author(s):  
Tsunemi Numata ◽  
Kiyoshi Furutani ◽  
Isamu Kimura ◽  
Satoru Yamada ◽  
Shoso Yamamoto
Keyword(s):  
Guinea Pig ◽  
Pig Skin

scholarly journals Selective inhibition by antiflamrnin-2 of thromboxane B2release from isolated and perfused guinea-pig lung

1992 ◽  
Vol 1 (4) ◽  
pp. 251-254
Author(s):  
Lidia Sautebin ◽  
Giuseppe Cirino ◽  
Massimo Di Rosa
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Calcium Ionophore ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Amino Acid Residues ◽  
A 23187 ◽  
Normal Lungs

Antiflammin-2 (AF2) is a nonapeptide corresponding to the amino acid residues 246–254 of lipocortin-1 showing anti-inflammatory activity both in vitro and in vivo. The effect of AF2 on the thromboxane B2(TXB2) and histamine release from isolated and perfused guinea-pig lungs has been studied. AF-2 (10–100 nM) inhibited leukotriene C4- (LTC4) (3 ng) and antigen-induced (ovalbumin, 1 mg) TXB2release in normal and sensitized lungs, respectively. In contrast AF-2 (100 nM) did not modify TXB2release induced by histamine (5 μg) or bradykinin (5 μg) in normal lungs. Antigen-induced histamine release was not affected by 100 nM AF-2 infusion. When tested in chopped lung fragments AF-2 (0.1–25 μM) did not modify the release of histamine and TXB2induced by antigen (ovalbumin, 10 μg ml−1) or calcium ionophore A 23187 (1 μM). Our results show that the inhibitory effect of AF-2 on TXB2release is selective and depends on the stimulus applied. In this respect AF-2 mimics, at least in part, the actions of both glucocorticoids and lipocortin-1.

The interaction between tetracycline and reconstituted guinea-pig-skin collagen in vitro

1964 ◽  
Vol 86 (3) ◽  
pp. 579-587 ◽  
Author(s):  
Richard Jacobs ◽  
William H. Harris ◽  
Elton P. Katz ◽  
Melvin J. Glimcher
Keyword(s):  
Guinea Pig ◽  
Pig Skin ◽  
Skin Collagen

scholarly journals Toxicity and medical countermeasure studies on the organophosphorus nerve agents VM and VX

2015 ◽  
Vol 471 (2176) ◽  
pp. 20140891 ◽  
Author(s):  
Helen Rice ◽  
Christopher H. Dalton ◽  
Matthew E. Price ◽  
Stuart J. Graham ◽  
A. Christopher Green ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Penetration Rate ◽  
Lethal Dose ◽  
Scientific Advice ◽  
Complete Protection ◽  
Pig Skin ◽  
Syrian Arab Republic ◽  
Medical Countermeasures

To support the effort to eliminate the Syrian Arab Republic chemical weapons stockpile safely, there was a requirement to provide scientific advice based on experimentally derived information on both toxicity and medical countermeasures (MedCM) in the event of exposure to VM, VX or VM–VX mixtures. Complementary in vitro and in vivo studies were undertaken to inform that advice. The penetration rate of neat VM was not significantly different from that of neat VX, through either guinea pig or pig skin in vitro . The presence of VX did not affect the penetration rate of VM in mixtures of various proportions. A lethal dose of VM was approximately twice that of VX in guinea pigs poisoned via the percutaneous route. There was no interaction in mixed agent solutions which altered the in vivo toxicity of the agents. Percutaneous poisoning by VM responded to treatment with standard MedCM, although complete protection was not achieved.

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