The Influence of Adjuvants on Antibody Production and Anaphylactic Hypersensitivity in the Guinea Pig

1970 ◽  
Vol 39 (2-3) ◽  
pp. 234-246 ◽  
Author(s):  
R. Hicks ◽  
N. Skeldon
Keyword(s):  
Guinea Pig ◽  
Antibody Production

Antibody Production in the Guinea Pig to Homologous Uvea.

1964 ◽  
Vol 117 (1) ◽  
pp. 150-154 ◽  
Author(s):  
W. B. Wacker ◽  
M. M. Lipton ◽  
F. E. Ongchua
Keyword(s):  
Guinea Pig ◽  
Antibody Production

scholarly journals Evaluation of Antiasthamic Activity of Electrohomeopathy Formulation Pettorale on Experimental Animals

2021 ◽  
Vol 11 (6) ◽  
pp. 121-126
Author(s):  
Prasant Kumar Sabat
Keyword(s):  
Amino Acids ◽  
Guinea Pig ◽  
Histamine Release ◽  
Antibody Production ◽  
Eosinophil Count ◽  
Leukocyte Count ◽  
Experimental Models ◽  
Phytochemical Screening ◽  
Experimental Animals ◽  
Egg Albumin

Objective: The current study was planned to evaluate the antiasthamatic effect of Electrohomeopathic medicine Pettorale in various experimental models. Methods: The antiasthmatic activity of Electrohomeopathic medicine Pettorale was studied on different experimental animals like histamine induced bronchospasm in guinea pig, haloperidol induced catalepsy in rats, egg albumin induced paw anaphylaxis in rats and milk induced leukocytosis in mice. Conclusion: Preliminary phytochemical screening has revealed the presence of alkaloids, glycosides, carbohydrates, amino acids, proteins, steroids and terpenoids. Petorella exhibited best antihistaminic activity at the dose of 400 mg/kg.  It inhibited haloperidol-induced catalepsy, increased leukocyte count and increased eosinophil count due to milk allergen. Antiasthmatic activity of Pettorale may be possible due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release. Keywords: Electrohomeopathy,   Pettorale, catalepsy, asthma, histamine

"Foreign Serum" Heterophile Antibodies in Patients Receiving Antithymocyte Antisera

Blood ◽  
1973 ◽  
Vol 42 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Bernard Pirofsky ◽  
J. C. Ramirez-Mateos ◽  
Anne August
Keyword(s):  
Guinea Pig ◽  
Antibody Production ◽  
Serum Sickness ◽  
Lymphoproliferative Diseases ◽  
Heterophile Antibody ◽  
Pig Kidney ◽  
Serum Type

Abstract Forty-six patients with venous immunologically mediated or lymphoproliferative diseases received goat antihuman thymocyte antisera globulin (ATG) therapy. Heterophile antibody production occurred in 91 % of these patients, following ATG administration. The heterophile antibody was absorbable with both guinea pig kidney and boiled beef erythrocyte antigens. This corresponds to a form of heterophile antibody previously reported as a "serum sickness" variety. The heterophile antibody was composed of a mixture of gamma G and gamma M antibodies and was partially absorbed by ATG. Serum sickness did not occur in any of these patients, in spite of the production of heterophile antibodies. It is recommended that the involved heterogenetic antigen be termed "foreign serum" variety, and the resulting antibody described as a "foreign serum" type of heterophile antibody.

scholarly journals ALLERGIC IRRITABILITY

1924 ◽  
Vol 40 (4) ◽  
pp. 503-515 ◽  
Author(s):  
Paul A. Lewis ◽  
Dorothy Loomis
Keyword(s):  
Guinea Pig ◽  
Antibody Production ◽  
Natural Resistance ◽  
Functional Nature

The guinea pig infected with virulent tubercle bacilli develops much more anti-sheep amboceptor than do controls when given like amounts of sheep red blood corpuscles. The curve of antibody production in the guinea pig when treated with sheep red blood corpuscles shows a departure from curves previously determined in other animals. These facts were ascertained as part of an effort to learn mbre of the functional nature of the inheritable factors controlling natural resistance to disease. The nature of some of the problems involved is outlined, and the limited bearing of the experiments on these is discussed.

The Effects of Homologous Testicular and Brain and Heterologous Testicular Homogenates combined with Adjuvant upon the Testes of Guinea-Pigs

Development ◽  
1958 ◽  
Vol 6 (1) ◽  
pp. 94-104
Author(s):  
Seymour Katsh ◽  
David W. Bishop
Keyword(s):  
Guinea Pig ◽  
Antibody Production ◽  
Guinea Pigs ◽  
Complement Fixation ◽  
Closely Related Species ◽  
Common Antigens ◽  
Heterologous Sperm ◽  
Species Specific ◽  
Sperm Immobilization ◽  
Ram Sperm

Numerous efforts have demonstrated antibody production after injection of spermatozoa into animals of the same species. For example, Metalnikoff (1900) and Kennedy (1924) reported anti-guinea-pig sperm ‘toxins’ in guinea-pigs; McCartney (1923) noted anti-rat sperm ‘toxins’ in rats; Pfeiffer (1905), Dittler (1920), and Pommerenke (1928) demonstrated anti-rabbit ‘spermatotoxins’ in rabbits. Antibody production against heterologous sperm has also been disclosed: Mudd & Mudd (1929) injected human, guinea-pig, bull, and ram sperm into rabbits and reported that the resultant antibodies were species specific. The absoluteness of specificity, both organ and species, however, has been qualified by the study of Lewis (1934), who found that brain and testicles possess common antigens, and Henle (1938) has extended Mudd & Mudd's (1929) observations on cross-reaction between sperm of closely related species. In the above-mentioned studies the methods for determining antisperm activity of antisera included complement-fixation, sperm-immobilization, agglutination, and precipitin tests.

Accumulation of T cells and local antippd antibody production in lymphokine-mediated chronic peritoneal inflammation in the guinea pig

1980 ◽  
Vol 132 (1) ◽  
pp. 23-33 ◽  
Author(s):  
W. B. Van Den Berg ◽  
A. C. M. Th. Van Maarsseveen ◽  
H. Mullink ◽  
R. J. Scheper
Keyword(s):  
T Cells ◽  
Guinea Pig ◽  
Antibody Production ◽  
Peritoneal Inflammation

scholarly journals INSULIN ANTIBODY VARIATIONS IN RABBITS AND GUINEA PIGS AND MULTIPLE ANTIGENIC DETERMINANTS ON INSULIN

1963 ◽  
Vol 118 (1) ◽  
pp. 55-71 ◽  
Author(s):  
Edward R. Arquilla ◽  
Jack Finn
Keyword(s):  
Guinea Pig ◽  
Antibody Production ◽  
Guinea Pigs ◽  
Genetic Factors ◽  
Insulin Antibodies ◽  
Antigenic Determinants ◽  
Antibody Molecule ◽  
Insulin Molecule ◽  
The Individual ◽  
The Relationship

1. A method is presented for measuring the degree to which insulin antibodies in one antiserum react with an insoluble insulin complex saturated with antibodies from a different antiserum. 2. Many rabbits produce antibodies which bind to portions of the insulin molecule to which antibodies from guinea pigs or other rabbits cannot bind. 3. Occasional guinea pigs produce antibodies which bind to portions of the insulin molecule to which antibodies from rabbits or other guinea pigs cannot bind. 4. Studies with labeled antisera and repeated incubations of test antisera with antibody insulin complexes demonstrate the individual antibody variations to be due to antibodies directed to different determinants and not to dissociation of antibodies from the same determinant on the insulin molecule. 5. More than one antibody molecule can simultaneously bind to an insulin molecule. 6. Insulin has a multiplicity of antigenic determinants. 7. The relationship between antigenic determinants, insulin antibodies, and neutralization of insulin by antisera is discussed. 8. The determinants to which insulin antibodies are directed appear to be characteristic for the individual rabbit or guinea pig immunized. It is postulated therefore that genetic factors direct antibody production toward specific determinants when insulin is the antigen.

scholarly journals Isolation ofLegionella pneumophilafrom water supplies: comparison of methods based on the guinea-pig and culture media

1983 ◽  
Vol 91 (2) ◽  
pp. 179-187 ◽  
Author(s):  
R. B. Fitzgeorge ◽  
P. J. Dennis
Keyword(s):  
Guinea Pig ◽  
Antibody Production ◽  
Legionella Pneumophila ◽  
Intraperitoneal Injection ◽  
Culture Media ◽  
Comparison Of Methods ◽  
Water Supplies ◽  
Immunofluorescent Microscopy

SUMMARYThe detection ofLegionella pneumophilain water via guinea-pig intraperitoneal injection has been compared with direct isolation of these organisms on semiselective BCYEα media. Both techniques were of similar sensitivity, detecting as few as 102L. pneumophilain 10 ml of water. However, at this concentration, detection using guinea-pig intraperitoneal injection was via the indirect parameters of antibody production and immunofluorescent microscopy. Isolation ofL. pneumophilafrom guinea-pig tissue for further investigation required > 107organisms injected and in this respect is relatively much less sensitive than direct isolation on semiselective BCYEα media. SinceL. micdadeiandL. longbeachaeare inhibited by one of the selective supplements used, other supplements and techniques need to be developed in order to avoid possible inhibition of otherLegionellaspecies.

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