Accumulation of T cells and local antippd antibody production in lymphokine-mediated chronic peritoneal inflammation in the guinea pig

1980 ◽  
Vol 132 (1) ◽  
pp. 23-33 ◽  
Author(s):  
W. B. Van Den Berg ◽  
A. C. M. Th. Van Maarsseveen ◽  
H. Mullink ◽  
R. J. Scheper
Keyword(s):  
T Cells ◽  
Guinea Pig ◽  
Antibody Production ◽  
Peritoneal Inflammation

scholarly journals Termination of aquired and natural immunological tolerance with specific complexes.

1975 ◽  
Vol 142 (2) ◽  
pp. 312-320 ◽  
Author(s):  
G S Habicht ◽  
J M Chiller ◽  
W O Weigle
Keyword(s):  
T Cells ◽  
B Cells ◽  
Bovine Serum Albumin ◽  
Guinea Pig ◽  
Serum Albumin ◽  
Gamma Globulin ◽  
Immunological Tolerance ◽  
Detailed Mechanism ◽  
Thyroid Lesions ◽  
Stimulation Of

It was possible to terminate the induced unresponsive state to bovine serum albumin (BSA) and the natural unresponsive state to autologous thyroglobulin in rabbits (RTg) by immunization with complexes composed of heterologous cross-reacting antibody and the tolerated antigens. The unresponsive state was terminated in rabbits made unresponsive by neonatal injections of BSA and then 3 mo later injected with complexes composed of BSA and guinea pig antihuman serum albumin. This termination was manifested by the presence of anti-BSA plaque-forming cells. Similarly, the natural unresponsive state was terminated in adult rabbits injected with complexes between RTg and guinea pig antibovine thyroglobulin (BTg) in that thyroid lesions and circulating anti-RTg were produced. The results can be best explained by the presence of unresponsive T cells and competent B cells, where the guinea pig gamma globulin (antibody) activates T cells specific for the guinea pig gamma globulin portion of the complexes and thus permits stimulation of B cells competent to the exposed determinants of the tolerated (BSA or RTg) portion of the complexes. The detailed mechanism for the activation of B cells in tolerant animals is discussed.

T cell-dependent suppression of antibody production. I. Characteristics of suppressor T cells following tolerance induction

1978 ◽  
Vol 8 (5) ◽  
pp. 360-370 ◽  
Author(s):  
A. Basten ◽  
J. F. A. P. Miller ◽  
R. Loblay ◽  
P. Johnson ◽  
Jennifer Gamble ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antibody Production ◽  
Tolerance Induction ◽  
Suppressor T Cells ◽  
Suppression Of Antibody Production

scholarly journals New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells

2018 ◽  
Vol 19 (3) ◽  
pp. 699-712 ◽  
Author(s):  
Lauriane Padet ◽  
Mélanie Dieudé ◽  
Annie Karakeussian‐Rimbaud ◽  
Bing Yang ◽  
Julie Turgeon ◽  
...  
Keyword(s):  
T Cells ◽  
Antibody Production ◽  
Immune Mechanisms ◽  
B1 Cells

Regulation of Immunoglobulin and Antibody Production Allotype Suppressor T Cells in Mice

1975 ◽  
Vol 27 (1) ◽  
pp. 57-83 ◽  
Author(s):  
Leonore A. Herzenberg ◽  
Ko Okumura ◽  
Charles M. Metzler
Keyword(s):  
T Cells ◽  
Antibody Production ◽  
Suppressor T Cells

scholarly journals GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 ◽  
Vol 136 (5) ◽  
pp. 1195-1206 ◽  
Author(s):  
John C. Ordal ◽  
F. Carl Grumet
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Genetic Control ◽  
Antibody Production ◽  
Lymphoid Cells ◽  
Antigen Challenge ◽  
Graft Versus Host ◽  
K Cells

The transfer of parental (H-2k/k) nonresponder lymphoid cells into heterozygous (H-2k/q) nonresponder recipients at the time of primary challenge with aqueous poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys [(T,G)-A--L] elicited the production of both IgM and IgG anti-(T,G)-A--L antibody. Normally, the production of IgG anti-(T,G)-A--L antibody is restricted to strains possessing the responder Ir-1 allele. The timing and intensity of the graft-versus-host (GVH) reaction required for this effect were found to be critical. Injection of H-2k/k cells into H-2k/q recipients 1 wk before antigen challenge did not elicit IgG anti-(T,G)-A--L antibody production, and markedly suppressed IgM anti-(T,G)-A--L antibody production. The transfer of alloimmune (H-2q-primed) H-2k/k cells at the time of antigen challenge was also associated with no IgG and little IgM anti-(T,G)-A--L antibody production. These data are consistent with the model that nonresponder thymus-derived lymphocytes (T cells) activated in a GVH reaction can substitute for (T,G)-A--L-reactive T cells to induce a shift from IgM to IgG anti-(T,G)-A--L antibody production.

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