Specific Inhibition of Contact Dermatitis to Dinitrochlorobenzene in Guinea Pigs by Injection of Haptens and Protein Conjugates

1964 ◽  
Vol 24 (2) ◽  
pp. 63-85 ◽  
Author(s):  
A.L. de Weck ◽  
J.R. Frey ◽  
H. Geleick
Keyword(s):  
Contact Dermatitis ◽  
Guinea Pigs ◽  
Specific Inhibition ◽  
Protein Conjugates

scholarly journals STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1937 ◽  
Vol 66 (3) ◽  
pp. 337-351 ◽  
Author(s):  
K. Landsteiner ◽  
M. W. Chase
Keyword(s):  
Contact Dermatitis ◽  
Strong Evidence ◽  
Guinea Pigs ◽  
Chemical Properties ◽  
Chemical Compounds ◽  
Protein Conjugates ◽  
Chemical Constitution ◽  
Simple Chemical ◽  
Picryl Chloride ◽  
Cutaneous Administration

It has been shown that by the cutaneous administration of simple chemical compounds in small quantities—2:4:6 trinitrochlorobenzene (picryl chloride) and 2:4 dinitrochlorobenzene, the latter a typical incitant of contact dermatitis in man—it is possible to induce true anaphylactic sensitization in guinea pigs, demonstrable by the intravenous injection of protein conjugates and by the Dale technique, using isolated uterine horns. This furnishes strong evidence for the formation of antigenic conjugates following application of substances of simple chemical constitution. Since the anaphylactic state is induced by the same method of administration that gives rise to cutaneous sensitivity, the assumption would appear justified, when one takes into account the chemical properties of the inciting substances, that the formation of conjugated antigens offers an explanation for the skin effects also. In the experiments with picryl chloride, anaphylactic antibodies, and occasionally precipitins, have been demonstrated. The differences between the cutaneous and anaphylactic types of sensitivity are discussed.

scholarly journals Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by DNFB.

Ensho ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 571-574
Author(s):  
Yoko Shoji ◽  
Tadashi Fukumura ◽  
Toshitaka Kudo ◽  
Akira Yanagawa ◽  
Jingoro Shimada ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Mycophenolic Acid ◽  
Guinea Pigs ◽  
Topical Preparation ◽  
Allergic Contact ◽  
Experimental Allergic

Effect of Highly Radiolabelled 2,4-Dinitrochlorobenzene (DNCB) on Experimental DNCB Contact Dermatitis in Guinea Pigs

Allergy ◽  
1984 ◽  
Vol 39 (7) ◽  
pp. 499-507 ◽  
Author(s):  
G. Filipp ◽  
G. Biro ◽  
F. Bahmer ◽  
H. Mitschke ◽  
G. Lehmann
Keyword(s):  
Contact Dermatitis ◽  
Guinea Pigs

scholarly journals Contact Dermatitis caused by 2-HEMA and GM Dentin Primer Solutions applied to Guinea Pigs and Humans

1996 ◽  
Vol 15 (1) ◽  
pp. 22-30,71 ◽  
Author(s):  
Kazuyuki KATSUNO ◽  
Atsufumi MANABE ◽  
Kazuo ITOH ◽  
Yoshihiro NAKAMURA ◽  
Sadao WAKUMOTO ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Guinea Pigs

scholarly journals Synthese von seitenkettenmodifizierten Analogen des Allergens Primin / Synthesis of Side-Chain-Modified Analogues of the Allergen Primin

1993 ◽  
Vol 48 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Wilfried A. König. ◽  
Holger Faasch ◽  
Holger Heitsch ◽  
Cornelia Colberg ◽  
Björn M. Hausen
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Chain Length ◽  
Guinea Pigs ◽  
Chemical Structure ◽  
Alkyl Chain ◽  
Maximum Activity ◽  
Side Chain ◽  
Allergic Contact ◽  
The Relationship

Benzoquinones such as primin (2-methoxy-6-pentyl-1,4-benzoquinone) from Primula obconica HANCE (Primulaceae) are known to be strong sensitizers and thus the source of severe allergic contact dermatitis (cell-mediated type of allergy). In order to determine the relationship between sensitizing capacity and chemical structure the synthesis of 19 side-chain-modified analogues of primin was carried out. With each of these primin derivatives 10 guinea pigs were sensitized using a modified FCA-method (FCA = Freund’s complete adjuvant). Elicitation was done open epicutaneously with 0.001 molar concentrations. In these sensitization experiments 2-methoxy-6-alkyl-1,4-benzoquinones (chain length C1-C15) showed ascending sensitizing potency with increasing number of the side chain carbon atoms reaching maximum activity at an alkyl chain of 10 to 11 carbons. Beyond this point a decrease of the sensitizing potency in correlation with a further prolongation of the side chain was observed.

Immunogenicity of p-Phenetidine, 2-Hydroxy-p-Phenetidine and their Protein Conjugates in Guinea Pigs, Rabbits and Man

1977 ◽  
Vol 53 (4) ◽  
pp. 319-328 ◽  
Author(s):  
P.E. Erne ◽  
A.F. Geczy ◽  
H. Spengler ◽  
A.L. de Weck ◽  
U.C. Dubach
Keyword(s):  
Guinea Pigs ◽  
Protein Conjugates
Sign in / Sign up

Export Citation Format

Share Document