Modelling of Drug Penetration into Human Skin Using a Multilayer Membrane System

1995 ◽  
Vol 8 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Reinhard Neubert ◽  
Wolfgang Wohlrab ◽  
Christina Bendas
Keyword(s):  
Human Skin ◽  
Membrane System ◽  
Drug Penetration ◽  
Multilayer Membrane

A multilayer membrane system for modelling drug penetration into skin

1991 ◽  
Vol 75 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Reinhard Neubert ◽  
Christina Bendas ◽  
Wolfgang Wohlrab ◽  
Birgit Gienau ◽  
Walter Fürst
Keyword(s):  
Membrane System ◽  
Drug Penetration ◽  
Multilayer Membrane

Modification of drug penetration into human skin using microemulsions

1997 ◽  
Vol 46 (3) ◽  
pp. 279-285 ◽  
Author(s):  
U Schmalfuß ◽  
R Neubert ◽  
W Wohlrab
Keyword(s):  
Human Skin ◽  
Drug Penetration

Drug penetration into and permeation through human skin assessed by Raman spectroscopy

1999 ◽  
Author(s):  
Adrian C. Williams ◽  
Elizabeth A. Carter ◽  
Howell G. Edwards ◽  
Brian W. Barry
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Drug Penetration

scholarly journals Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles

2017 ◽  
Vol 114 (14) ◽  
pp. 3631-3636 ◽  
Author(s):  
Robert Schulz ◽  
Kenji Yamamoto ◽  
André Klossek ◽  
Roman Flesch ◽  
Stefan Hönzke ◽  
...  
Keyword(s):  
Free Energy ◽  
Diffusion Equation ◽  
Human Skin ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Drug Penetration ◽  
Energy Profiles ◽  
Long Time ◽  
Free Energy Profiles

Based on experimental concentration depth profiles of the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration by the 1D general diffusion equation that accounts for spatial variations in the diffusivity and free energy. For this, we numerically invert the diffusion equation and thereby obtain the diffusivity and the free-energy profiles of the drug as a function of skin depth without further model assumptions. As the only input, drug concentration profiles derived from X-ray microscopy at three consecutive times are used. For dexamethasone, skin barrier function is shown to rely on the combination of a substantially reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominant at short times, and a pronounced free-energy barrier at the transition from the epidermis to the dermis underneath, which determines the drug distribution in the long-time limit. Our modeling approach, which is generally applicable to all kinds of barriers and diffusors, allows us to disentangle diffusivity from free-energetic effects. Thereby we can predict short-time drug penetration, where experimental measurements are not feasible, as well as long-time permeation, where ex vivo samples deteriorate, and thus span the entire timescales of biological barrier functioning.

Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin

2019 ◽  
Vol 299 ◽  
pp. 138-148 ◽  
Author(s):  
Janna Frombach ◽  
Michael Unbehauen ◽  
Indah N. Kurniasih ◽  
Fabian Schumacher ◽  
Pierre Volz ◽  
...  
Keyword(s):  
Human Skin ◽  
Antigen Presenting Cells ◽  
Drug Penetration ◽  
Antigen Presenting
Sign in / Sign up

Export Citation Format

Share Document