Drug penetration into and permeation through human skin assessed by Raman spectroscopy

1999 ◽  
Author(s):  
Adrian C. Williams ◽  
Elizabeth A. Carter ◽  
Howell G. Edwards ◽  
Brian W. Barry
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Drug Penetration

Theoretical Analysis of Blood Alcohol Detection Based on Raman Spectroscopy

2011 ◽  
Vol 314-316 ◽  
pp. 682-685
Author(s):  
Yan Li ◽  
Sheng Wang ◽  
Xiao Lei Wang ◽  
Wen Kui Ma ◽  
Jun Liu
Keyword(s):  
Raman Spectroscopy ◽  
Theoretical Analysis ◽  
Human Skin ◽  
Human Blood ◽  
Rapid Detection ◽  
Health And Safety ◽  
Blood Alcohol ◽  
Alcohol Content ◽  
Broad Application ◽  
Safety Technology

This paper introduces an analysis technology in detecting the alcohol content in human blood after drunken that bases on reflectionof Raman spectroscopy. This is a fast, non-contact, health and safety technology which take advantage of the human skin. The technology has a broad application in rapid detection of alcohol content in human blood.

In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy

2018 ◽  
Vol 19 (7) ◽  
pp. 3177-3186 ◽  
Author(s):  
Vamshi Krishna Tippavajhala ◽  
Taciana D. Magrini ◽  
Daniele C. Matsuo ◽  
Michely G. P. Silva ◽  
Priscila P. Favero ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Skin Hydration ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman

Raman spectroscopy of human skin: looking for a quantitative algorithm to reliably estimate human age

2015 ◽  
Vol 20 (6) ◽  
pp. 065008 ◽  
Author(s):  
Giuseppe Pezzotti ◽  
Marco Boffelli ◽  
Daisuke Miyamori ◽  
Takeshi Uemura ◽  
Yoshinori Marunaka ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin

Infrared and Raman Spectroscopy of Human Skin in vivo

2017 ◽  
Author(s):  
Gerald W. Lucassen ◽  
Peter J. Caspers ◽  
Gerwin J. Puppels ◽  
Maxim E. Darvin ◽  
Juergen Lademann
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Infrared And Raman Spectroscopy

Kinetics of optical clearing of human skin studied in vivo using portable Raman spectroscopy

2020 ◽  
Vol 17 (10) ◽  
pp. 105601
Author(s):  
Qingyu Lin ◽  
Ekaterina N Lazareva ◽  
Vyacheslav I Kochubey ◽  
Yixiang Duan ◽  
Valery V Tuchin
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Optical Clearing ◽  
Portable Raman Spectroscopy ◽  
Kinetics Of ◽  
Portable Raman

scholarly journals Franz Cell Diffusion Testing and Quantitative Confocal Raman Spectroscopy: In Vitro-In Vivo Correlation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 887
Author(s):  
Fotis Iliopoulos ◽  
Peter J. Caspers ◽  
Gerwin J. Puppels ◽  
Majella E. Lane
Keyword(s):  
Raman Spectroscopy ◽  
Propylene Glycol ◽  
Human Skin ◽  
Ternary Mixtures ◽  
Drug Bioavailability ◽  
Confocal Raman Spectroscopy ◽  
Topical Formulations ◽  
Confocal Raman

Previously, we reported the use of Confocal Raman Spectroscopy (CRS) to investigate the topical delivery of actives and excipients. We have also correlated the results from CRS with findings from in vitro diffusion studies in human skin. However, until now CRS has only been used as a semi-quantitative method of determining the skin uptake of molecules, with results expressed as arbitrary units of signal intensity. Clearly, this posed challenges for using CRS to determine skin delivery and to assess the drug bioavailability and bioequivalence of topical formulations. In the present work, the permeation of niacinamide (NIA) from various formulations in human skin was studied in vitro using conventional Franz cells and in vivo using a quantitative CRS method under finite dose conditions. The selection of NIA was based on its wide use in pharmaceutical and personal care formulations for many years. This is the first fully quantitative study to compare these methods. The vehicles investigated were neat Transcutol® P (TC); binary combinations of propylene glycol (PG) with propylene glycol monolaurate (PGML); and ternary mixtures of PG, PGML, and isopropyl myristate (IPM). These solvents were selected to encompass a range of physicochemical properties. NIA permeation was evident from all formulations in vitro and in vivo. The vehicles PG:PGML and PG:PGML:IPM delivered comparable amounts across the skin in vitro at 24 h (100.3–106.7 µg/cm2, p > 0.05) that were significantly higher compared with those of TC (1.3 µg/cm2, p < 0.05). An excellent in vitro in vivo correlation (R2 = 0.98) was found following the linear regression of the cumulative amounts of NIA permeated in vitro and the amounts of NIA at 2 μm in the skin measured with CRS. A very good correlation between the cumulative permeation of NIA in vitro and the total amount of NIA that penetrated the stratum corneum (SC) per unit of surface area (μg/cm2) in vivo was also observed, with a Pearson correlation coefficient (R2) of 0.94. The findings support the use of CRS for the quantitative measurement of actives delivered to the skin in vivo. Future studies will focus on exploring the reproducibility and reliability of the method by investigating the delivery of different actives from a wider range of vehicles. Additionally, quantitative CRS will be evaluated further as a method for assessing the bioequivalence of topical formulations.

Modification of drug penetration into human skin using microemulsions

1997 ◽  
Vol 46 (3) ◽  
pp. 279-285 ◽  
Author(s):  
U Schmalfuß ◽  
R Neubert ◽  
W Wohlrab
Keyword(s):  
Human Skin ◽  
Drug Penetration
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