DNA Synthesis in Infectious Mononucleosis and Acute Leukaemia

1963 ◽  
Vol 29 (5) ◽  
pp. 257-266 ◽  
Author(s):  
A.J. Hale ◽  
E.H. Cooper
Keyword(s):  
Dna Synthesis ◽  
Infectious Mononucleosis ◽  
Acute Leukaemia

scholarly journals DNA and RNA Synthesis of Circulating Atypical Lymphocytes in Infectious Mononucleosis

Blood ◽  
1965 ◽  
Vol 25 (2) ◽  
pp. 197-203 ◽  
Author(s):  
LOIS B. EPSTEIN ◽  
GEORGE BRECHER
Keyword(s):  
Dna Synthesis ◽  
Infectious Mononucleosis ◽  
Rna Synthesis ◽  
Mononuclear Cells ◽  
Early Period ◽  
Dna And Rna ◽  
Atypical Cells ◽  
Dna And Rna Synthesis ◽  
Considerable Period ◽  
Active Proliferation

Abstract The percentages of mononuclear cells synthesizing DNA and RNA in serial studies of blood from 13 patients with infectious mononucleosis were determined. Early in the disease a high percentage of atypical lymphocytes were in DNA synthesis but this percentage decreased rapidly as the disease progressed. Late in the disease many atypical lymphocytes were still present but few, if any, were synthesizing DNA. Similar results were found for RNA synthesis. Presumably active proliferation of atypical cells in the tissues is restricted to an early period of the disease, whereas release of such atypical cells may continue for a considerable period.

DNA Synthesis and DNA Content of Leucocytes in Acute Leukaemia

Nature ◽  
1967 ◽  
Vol 216 (5111) ◽  
pp. 134-136 ◽  
Author(s):  
MINOU D. FOADI ◽  
E. H. COOPER ◽  
R. M. HARDISTY
Keyword(s):  
Dna Synthesis ◽  
Dna Content ◽  
Acute Leukaemia

Use of Antibody to aid Visualization of Protein at the Termini of Bacteriophage Ø29 DNA

1980 ◽  
Vol 38 ◽  
pp. 540-541
Author(s):  
Dwight Anderson ◽  
Charlene Peterson ◽  
Gursaran Notani ◽  
Bernard Reilly
Keyword(s):  
Electron Microscopy ◽  
Bacillus Subtilis ◽  
Dna Synthesis ◽  
Restriction Endonuclease ◽  
Protein Complex ◽  
Protein Product ◽  
Viral Dna ◽  
Small Proteins ◽  
Antibody Labeling ◽  
Subtilis Bacteriophage

The protein product of cistron 3 of Bacillus subtilis bacteriophage Ø29 is essential for viral DNA synthesis and is covalently bound to the 5’-termini of the Ø29 DNA. When the DNA-protein complex is cleaved with a restriction endonuclease, the protein is bound to the two terminal fragments. The 28,000 dalton protein can be visualized by electron microscopy as a small dot and often is seen only when two ends are in apposition as in multimers or in glutaraldehyde-fixed aggregates. We sought to improve the visibility of these small proteins by use of antibody labeling.

Therapeutic role of cell kinetics in acute leukaemia

1978 ◽  
Vol 7 (2) ◽  
pp. 339-362 ◽  
Author(s):  
Zalmen A. Arlin ◽  
Jerrold Fried ◽  
Bayard D. Clarkson
Keyword(s):  
Acute Leukaemia ◽  
Cell Kinetics ◽  
Therapeutic Role
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