Division of Leukocytes Already in DNA Synthesis from Patients with Acute Leukemia and Infectious Mononucleosis

1967 ◽  
Vol 38 (3) ◽  
pp. 163-169 ◽  
Author(s):  
A.A. MacKinney, jr.
Keyword(s):  
Acute Leukemia ◽  
Dna Synthesis ◽  
Infectious Mononucleosis

In Vitro suppression of DNA synthesis by a remission induction agent and its correlation with response in adult acute leukemia

1984 ◽  
Vol 20 (4) ◽  
pp. 507-514 ◽  
Author(s):  
Anne-Marie Maddox ◽  
Dennis A. Johnston ◽  
Barthel Barlogie ◽  
Mohamed Haq ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Dna Synthesis ◽  
Remission Induction ◽  
Induction Agent

Concurrent infectious mononucleosis and acute leukemia

1971 ◽  
Vol 50 (2) ◽  
pp. 208-217 ◽  
Author(s):  
David A. Stevens ◽  
Paul H. Levine ◽  
Sook K. Lee ◽  
Marilyn J. Sonley ◽  
Deward E. Waggoner
Keyword(s):  
Acute Leukemia ◽  
Infectious Mononucleosis

Infectious mononucleosis and acute leukemia

JAMA ◽  
1971 ◽  
Vol 215 (7) ◽  
pp. 1159c-1159 ◽  
Author(s):  
J. F. Fraumeni
Keyword(s):  
Acute Leukemia ◽  
Infectious Mononucleosis

scholarly journals The Size and Transit Time of Nondividing Subpool of Precursor Cells in Acute Leukemia

Blood ◽  
1967 ◽  
Vol 29 (1) ◽  
pp. 63-76 ◽  
Author(s):  
MAX SHIUMING LIN ◽  
BERTHA A. BOURONCLE
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Leukemia ◽  
Dna Synthesis ◽  
Transit Time ◽  
Myeloid Leukemia ◽  
Precursor Cells ◽  
Synthesis Time ◽  
In Vitro System ◽  
Acute Myeloid

Abstract 1. In order to elucidate the postulation and to quantitate the size and transit time of the nondividing subpool of precursor cells in acute leukemia, mathematical formulas based on a prolonged-labeling model were derived for the following kinetic parameters: (1) DNA synthesis time and generation time of dividing precursor cells in normal hemopoiesis and in acute leukemia. (2) size and transit time of the nondividing subpool of precursor cells in acute leukemia. The validity of the assumptions made in the model was discussed. 2. In vitro experimental estimation of the above kinetic parameters was done for the myeloid precursor pool in four cases: two with normal hemopoiesis; one, acute myeloid leukemia; one, subacute myeloid leukemia. 3. Variable decrease with time in availability of tritiated thymidine given initially in single dose to the in vitro system was observed and discussed. 4. DNA synthesis time and generation time of the dividing myeloid precursor cells in the two leukemic patients were not significantly different from, and were no shorter than, the corresponding values for normal myeloid precursor cells in the two nonleukemic patients. Thus it allows the prediction that as much as 86 per cent of the myeloid precursor cells in the marrow may be nondividing in acute myeloid leukemia. 5. In a case of acute myeloid leukemia about 87 per cent of the myeloid precursor cells in the marrow were estimated as nondividing with nondividing subpool transit time of about 32 days in closed in vitro system. The probable meanings of these in vitro estimates in vivo were discussed. 6. The result and analytical review of literature support the postulation of heterogeneous acute leukemia precursor cells with the nondividing fraction consisting of end cells being maintained by the dividing fraction. It is also suggested that a small fraction of nondividing cells may be capable of DNA synthesis and thus be initially-labeling. More definitive approaches to the problems await future investigation.

scholarly journals DNA and RNA Synthesis of Circulating Atypical Lymphocytes in Infectious Mononucleosis

Blood ◽  
1965 ◽  
Vol 25 (2) ◽  
pp. 197-203 ◽  
Author(s):  
LOIS B. EPSTEIN ◽  
GEORGE BRECHER
Keyword(s):  
Dna Synthesis ◽  
Infectious Mononucleosis ◽  
Rna Synthesis ◽  
Mononuclear Cells ◽  
Early Period ◽  
Dna And Rna ◽  
Atypical Cells ◽  
Dna And Rna Synthesis ◽  
Considerable Period ◽  
Active Proliferation

Abstract The percentages of mononuclear cells synthesizing DNA and RNA in serial studies of blood from 13 patients with infectious mononucleosis were determined. Early in the disease a high percentage of atypical lymphocytes were in DNA synthesis but this percentage decreased rapidly as the disease progressed. Late in the disease many atypical lymphocytes were still present but few, if any, were synthesizing DNA. Similar results were found for RNA synthesis. Presumably active proliferation of atypical cells in the tissues is restricted to an early period of the disease, whereas release of such atypical cells may continue for a considerable period.

scholarly journals Infectious mononucleosis prior to acute leukemia: A possible role for the epstein-barr virus

Cancer ◽  
1972 ◽  
Vol 30 (4) ◽  
pp. 875-880 ◽  
Author(s):  
Paul H. Levine ◽  
David A. Stevens ◽  
Peter F. Coccia ◽  
Lyubica Dabich ◽  
Augustine Roland
Keyword(s):  
Acute Leukemia ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Infectious Mononucleosis And Acute Leukemia

JAMA ◽  
1971 ◽  
Vol 215 (7) ◽  
pp. 1159 ◽  
Author(s):  
Joseph F. Fraumeni
Keyword(s):  
Acute Leukemia ◽  
Infectious Mononucleosis
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