Different Expression and Clinical Role of S100A4 in Serous Ovarian Carcinoma at Different Anatomic Sites

Tumor Biology ◽  
2009 ◽  
Vol 30 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Gunhild M. Mælandsmo ◽  
Vivi Ann Flørenes ◽  
Mai T.P. Nguyen ◽  
Kjersti Flatmark ◽  
Ben Davidson
Keyword(s):  
Ovarian Carcinoma ◽  
Clinical Role ◽  
Serous Ovarian Carcinoma

scholarly journals Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma

2018 ◽  
Vol 474 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Marta Brunetti ◽  
Arild Holth ◽  
Ioannis Panagopoulos ◽  
Anne Cathrine Staff ◽  
Francesca Micci ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Clinical Role ◽  
Dipeptidyl Peptidases

scholarly journals The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma

2020 ◽  
Vol 21 (15) ◽  
pp. 5237 ◽  
Author(s):  
Natalie Filippov-Levy ◽  
Reuven Reich ◽  
Ben Davidson
Keyword(s):  
Matrix Metalloproteinase ◽  
Cell Signaling ◽  
Ovarian Carcinoma ◽  
Serous Carcinoma ◽  
Spheroid Formation ◽  
Clinical Role ◽  
Cerna Network ◽  
Non Coding Rna ◽  
Long Non Coding Rna

The objective of the present study was to analyze the biological and clinical role of the long non-coding RNA LOC642852 in ovarian carcinoma (OC). LOC642852 expression was analyzed in seven OC cell lines (OVCAR-3, OVCAR-8, OVCA 433, OVCA 429, OC 238, DOV13, ES-2) and 139 high-grade serous carcinoma (HGSC) specimens (85 effusions, 54 surgical specimens). Following LOC642852 knockout (KO) using the CRISPR/Cas9 system, OVCAR-8 HGSC cells were analyzed for spheroid formation, migration, invasion, proliferation, matrix metalloproteinase (MMP) activity, and expression of cell signaling proteins. OVCAR-8 cells with LOC642852 KO were significantly less motile and less invasive compared to controls, with no differences in spheroid formation, proliferation, or matrix metalloproteinase (MMP) activity. Total Akt and Erk levels were comparable in controls and KO cells, but their phosphorylation was significantly increased in the latter. In clinical specimens, LOC642852 was overexpressed in ovarian tumors and omental/peritoneal metastases compared to effusion specimens (p = 0.013). A non-significant trend for shorter overall (p = 0.109) and progression-free (p = 0.056) survival was observed in patients with HGSC effusions with high LOC642852 levels. Bioinformatics analysis showed potential roles for LOC642852 as part of the TLE3/miR-221-3p ceRNA network and in relation to the FGFR3 protein. In conclusion, LOC642852 inactivation via CRISPR/Cas9 affects cell signaling, motility, and invasion in HGSC cells. LOC642852 is differentially expressed in HGSC cells at different anatomical sites. Its potential role in regulating the TLE3/miR-221-3p ceRNA network and FGFR3 merits further research.

scholarly journals Low RAP80 mRNA Expression Correlates with Shorter Survival in Sporadic High-Grade Serous Ovarian Carcinoma

2017 ◽  
Vol 32 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Margarita Romeo ◽  
Niki Karachaliou ◽  
Imane Chaid ◽  
Cristina Queralt ◽  
Itziar De Aguirre ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Mrna Expression ◽  
Residual Disease ◽  
Progression Free Survival ◽  
Figo Stage ◽  
High Grade ◽  
Platinum Compounds ◽  
Serous Ovarian Carcinoma ◽  
Platinum Based Chemotherapy

Objective Homologous recombination (HR) is frequently impaired in sporadic high-grade serous ovarian carcinoma (sHGSOC) due to deficiencies in BRCA1/2 genes, a situation associated with hypersensitivity to platinum compounds. Alterations in other genes can also cause HR deficiency. Preclinical data show that RAP80 is an HR–pathway-related gene that influences BRCA1 activity. RAP80 has been reported to affect outcome in some solid neoplasms. This study investigates the role of RAP80 in sHGSOC survival. Methods mRNA expression of RAP80 was analyzed in tumor samples from 35 patients who postoperatively received standard platinum-based chemotherapy. The effects of RAP80 expression on progression-free survival (PFS) and overall survival (OS) were examined by means of Cox regressions. The clinical variables known to have prognostic value (FIGO stage, residual disease at surgery, and debulking surgery) were included as covariates in the analysis. BRCA1 was analyzed given the moderate correlations with RAP80. Results Median follow-up, PFS and OS were 61.3, 20.2 and 62.8 months, respectively. Low RAP80 expression levels were associated with shorter PFS ( HR = 1.449, p = 0.007) and OS ( HR = 1.331, p = 0.047). Conclusions This is the first study to show a potential prognostic role of RAP80 expression in patients with HGSOC. The results suggest that HR deficiency due to low RAP80 expression is not associated with hypersensitivity to platinum compounds in sHGSOC.

scholarly journals The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (31) ◽  
pp. 31593-31603 ◽  
Author(s):  
Euan A. Stronach ◽  
Paula Cunnea ◽  
Christina Turner ◽  
Tankut Guney ◽  
Radhika Aiyappa ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Interleukin 8 ◽  
High Grade ◽  
Serous Ovarian Carcinoma

The role of secondary cytoreduction in patients with recurrent low-grade serous ovarian carcinoma

2014 ◽  
Vol 133 ◽  
pp. 88-89
Author(s):  
E.R. King ◽  
C.C.L. Sun ◽  
P.T. Ramirez ◽  
K.M. Schmeler ◽  
A. Malpica ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Low Grade ◽  
Serous Ovarian Carcinoma

Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions

2007 ◽  
Vol 38 (7) ◽  
pp. 1030-1036 ◽  
Author(s):  
Ben Davidson ◽  
Aasmund Berner ◽  
Claes G. Trope' ◽  
Tian-Li Wang ◽  
Ie-Ming Shih
Keyword(s):  
Ovarian Carcinoma ◽  
Clinical Role ◽  
Broad Complex ◽  
Zinc Protein
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