scholarly journals The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (31) ◽  
pp. 31593-31603 ◽  
Author(s):  
Euan A. Stronach ◽  
Paula Cunnea ◽  
Christina Turner ◽  
Tankut Guney ◽  
Radhika Aiyappa ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Interleukin 8 ◽  
High Grade ◽  
Serous Ovarian Carcinoma

scholarly journals Low RAP80 mRNA Expression Correlates with Shorter Survival in Sporadic High-Grade Serous Ovarian Carcinoma

2017 ◽  
Vol 32 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Margarita Romeo ◽  
Niki Karachaliou ◽  
Imane Chaid ◽  
Cristina Queralt ◽  
Itziar De Aguirre ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Mrna Expression ◽  
Residual Disease ◽  
Progression Free Survival ◽  
Figo Stage ◽  
High Grade ◽  
Platinum Compounds ◽  
Serous Ovarian Carcinoma ◽  
Platinum Based Chemotherapy

Objective Homologous recombination (HR) is frequently impaired in sporadic high-grade serous ovarian carcinoma (sHGSOC) due to deficiencies in BRCA1/2 genes, a situation associated with hypersensitivity to platinum compounds. Alterations in other genes can also cause HR deficiency. Preclinical data show that RAP80 is an HR–pathway-related gene that influences BRCA1 activity. RAP80 has been reported to affect outcome in some solid neoplasms. This study investigates the role of RAP80 in sHGSOC survival. Methods mRNA expression of RAP80 was analyzed in tumor samples from 35 patients who postoperatively received standard platinum-based chemotherapy. The effects of RAP80 expression on progression-free survival (PFS) and overall survival (OS) were examined by means of Cox regressions. The clinical variables known to have prognostic value (FIGO stage, residual disease at surgery, and debulking surgery) were included as covariates in the analysis. BRCA1 was analyzed given the moderate correlations with RAP80. Results Median follow-up, PFS and OS were 61.3, 20.2 and 62.8 months, respectively. Low RAP80 expression levels were associated with shorter PFS ( HR = 1.449, p = 0.007) and OS ( HR = 1.331, p = 0.047). Conclusions This is the first study to show a potential prognostic role of RAP80 expression in patients with HGSOC. The results suggest that HR deficiency due to low RAP80 expression is not associated with hypersensitivity to platinum compounds in sHGSOC.

scholarly journals Morphological basics of ovarian tumor histogenesis

2020 ◽  
Vol 16 (1) ◽  
pp. 78-84
Author(s):  
F. V. Novikov ◽  
I. S. Luneva ◽  
E. S. Mishina ◽  
M. V. Mnikhovich
Keyword(s):  
Stem Cells ◽  
Ovarian Carcinoma ◽  
Fallopian Tube ◽  
Ovarian Tumor ◽  
Surface Epithelium ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
New Hypothesis ◽  
Tumor Histogenesis

Researches about the origin of epithelial ovarian tumors (EOT) tell about its conception. In particular, the origin of cells from the secondary mullerian system. Also, in the article we examine a new hypothesis that the EOT originates in the epithelium of the fallopian tube (FT) – their contradictoriness and new conception of “precursor escape” which tries to explain the phenomenon of injuries absence of FT by high-grade serous ovarian carcinoma. Carcinogenesis from the FT represents great opportunities for reassessment of clinical data. Also, the article represents the role of stem cells of the surface epithelium of ovaries and FT in EOT carcinogenesis.

Neoplastic cellularity is associated with clinical and molecular features of high-grade serous ovarian carcinoma

2015 ◽  
Vol 139 (1) ◽  
pp. 196
Author(s):  
C. Morse ◽  
B. Norquist ◽  
S. Bernards ◽  
M. Harrell ◽  
K. Agnew ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
High Grade ◽  
Molecular Features ◽  
Serous Ovarian Carcinoma
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