The Effect of the New H2-Receptor Antagonist Mifentidine on Gastric Secretion, Gastric Emptying and Experimental Gastric and Duodenal Ulcers in the Rat: Comparison with Cimetidine and Ranitidine

Digestion ◽  
1986 ◽  
Vol 33 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Carmelo Scarpignato ◽  
Martin Tangwa ◽  
Roberto Tramacere ◽  
Piero Del Soldato
Keyword(s):  
Gastric Emptying ◽  
Gastric Secretion ◽  
Receptor Antagonist ◽  
Duodenal Ulcers

The effect of the CCKA receptor antagonist loxiglumide on hormonal responses, gastric emptying and appetite in humans

2000 ◽  
Vol 94 (1-3) ◽  
pp. 71
Author(s):  
Linda M. Morgan ◽  
Samantha J. Long ◽  
Andrew Sutton ◽  
Anastasia Giouvanoudi ◽  
Behain Amaee ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Receptor Antagonist ◽  
Hormonal Responses

scholarly journals Effects of the 5-HT3 receptor antagonist ICS 205-930 on fat-delayed gastric emptying and antral motor activity.

1990 ◽  
Vol 30 (1) ◽  
pp. 41-48 ◽  
Author(s):  
G Stacher ◽  
H Bergmann ◽  
C Schneider ◽  
G Steiner-Mittelbach ◽  
G Gaupmann ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Motor Activity ◽  
Receptor Antagonist ◽  
Delayed Gastric Emptying ◽  
Ics 205 930

Effects of bombesin on food intake and gastric acid secretion in cats

1989 ◽  
Vol 256 (1) ◽  
pp. R181-R186
Author(s):  
A. Bado ◽  
M. J. Lewin ◽  
M. Dubrasquet
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Gastric Secretion ◽  
Acid Secretion ◽  
Gastric Fistula ◽  
Single Class ◽  
Heidenhain Pouch ◽  
Daily Food Intake ◽  
Feeding Experiments ◽  
Daily Food

The brain and gut peptide bombesin has been reported both to stimulate gastric secretion and to induce satiety. To understand how the peripheral administration of bombesin affects food intake and whether gastric mechanisms are involved, a comparative study of the doses of bombesin active on gastric secretion, gastric emptying, and food intake was undertaken in cats provided with a gastric fistula and a denervated Heidenhain pouch. The smallest dose of intravenous bombesin that stimulated significantly basal acid secretion (20 pmol.kg-1.h-1) by the gastric fistula also enhanced meal-stimulated acid secretion by the Heidenhain pouch (+138%, P less than 0.01), delayed gastric emptying of a liquid protein meal (-30%, P less than 0.01), and suppressed food intake when the test meal was allowed to reach the stomach (-15%, P less than 0.01). Conversely, in sham-feeding experiments, the same dose of bombesin increased food intake (+35%, P less than 0.01). In full-day experiments conducted in nonfasted cats, bombesin decreased both the food intake in the 4-h period after the infusion and the daily food intake, whereas octapeptide cholecystokinin induced a transient satiety but did not decrease daily food intake. These results indicate that in cats the interaction of bombesin with "pregastric" mechanisms is not sufficient to induce satiety and that a relation could exist between the effects of bombesin on gastric secretion, emptying, and food intake. A single class of receptors might be involved in these peripheral effects of bombesin.

Effects of Met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys

1983 ◽  
Vol 245 (2) ◽  
pp. G196-G200
Author(s):  
P. T. Shea-Donohue ◽  
N. Adams ◽  
J. Arnold ◽  
A. Dubois
Keyword(s):  
Gastric Emptying ◽  
Receptor Antagonist ◽  
Rhesus Monkeys ◽  
Endocrine Cells ◽  
Chloride Ion ◽  
Opiate Receptor ◽  
Sodium Ion ◽  
Dilution Technique ◽  
Gastric Function ◽  
Sodium Potassium

Recent studies have demonstrated the presence of enkephalins in gastric neurons and endocrine cells; however, their role in the regulation of gastric function is unknown. The effect of Met-enkephalin (MET), the stable analogue of Met-enkephalin [D-Ala2]Met-enkephalinamide (DMET), and the opiate receptor antagonist naloxone were studied in five chair-adapted rhesus monkeys. A dye-dilution technique was used to determine simultaneously fractional emptying rate, hydrogen, sodium, potassium, and chloride ion output, and fluid output. Both MET and DMET significantly inhibited fractional emptying rate and H+ secretion following an 80-ml water meal. Only MET, however, significantly altered fluid and sodium ion output. Naloxone had no effect on gastric function following the water meal.

Duodenogastric reflux in the dog

1982 ◽  
Vol 242 (6) ◽  
pp. G603-G607
Author(s):  
A. Sonnenberg ◽  
S. A. Muller-Lissner ◽  
G. Schattenmann ◽  
J. R. Siewert ◽  
A. L. Blum
Keyword(s):  
Gastric Emptying ◽  
Gastric Secretion ◽  
Intravenous Infusion ◽  
Duodenogastric Reflux ◽  
Gastric Volume ◽  
Gastric Digestion ◽  
Protein Meal ◽  
Gastric Emptying Rate

Duodenogastric reflux, gastric emptying, and gastric secretion were measured simultaneously by a double-marker technique after instillation of a liquid lipid meal (300 ml Intralipid) or a protein meal (300 ml Bactopeptone) in five trained mongrel dogs. A lipid meal was emptied slower and elicited less volume secretion than a protein meal. Duodenogastric reflux rate and intragastric accumulation of duodenal contents were similar with both meals. Intravenous infusion of atropine slowed gastric emptying and inhibited gastric volume secretion only in the case of protein meal. Atropine increased duodenogastric reflux rate and gastric accumulation of duodenal contents with both protein and lipid meals. The percentage of duodenal contents inside the stomach increased continuously during gastric emptying; it did not exceed 20% with both meals given alone and 40% with both meals given together with atropine. It is concluded that duodenogastric reflux and gastric accumulation of duodenal contents are common phenomena during gastric digestion of a meal. The degree of such accumulation does not depend on the type of meal. Intragastric accumulation of duodenal contents is increased when duodenogastric reflux rate is stimulated and when gastric emptying rate is inhibited simultaneously.

scholarly journals Effect of Secretin and Cholecystokinin on Gastric Emptying and Gastric Secretion in Man

1970 ◽  
Vol 58 (6) ◽  
pp. 820-827 ◽  
Author(s):  
W.Y. Chey ◽  
S. Hitanant ◽  
J. Hendricks ◽  
S.H. Lorber
Keyword(s):  
Gastric Emptying ◽  
Gastric Secretion
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