Antineutrophil Cytoplasmic Antibodies (ANCA)-Associated Crescentic Glomerulonephritis and Propylthiouracil Therapy

Nephron ◽  
1996 ◽  
Vol 73 (4) ◽  
pp. 701-703 ◽  
Author(s):  
Shigekazu Yuasa ◽  
Mayuko Hashimoto ◽  
Takafumi Yura ◽  
Tohru Sumikura ◽  
Norihiro Takahashi ◽  
...  
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Antineutrophil Cytoplasmic Antibodies

scholarly journals Rare case of atypical crescentic glomerulonephritis and interstitial lung disease with negative anti-GBM antibody and positive anti-MPO antibody

2019 ◽  
Vol 12 (8) ◽  
pp. e229256 ◽  
Author(s):  
Alexander Hanna ◽  
Jenny Ross ◽  
Fernanda Heitor
Keyword(s):  
Hepatitis B ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Rare Case ◽  
Crescentic Glomerulonephritis ◽  
Kidney Biopsy ◽  
Flank Pain ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Hepatitis B Infection ◽  
Double Positive

A 70-year-old man presented with 1 month of haematuria and mild right-sided flank pain with no other symptoms. Diagnostic workup included serum studies which showed the presence of antimyeloperoxidase antibodies, a kidney biopsy which demonstrated necrotising crescentic glomerulonephritis with linear immunofluorescence of the basement membrane, and electron microscopy which exhibited thickening of the glomerular basement membrane. Incidentally, the patient was discovered to have a latent hepatitis B infection, which complicated immunosuppressive therapy. He was treated with a course of plasmapheresis and methylprednisolone, followed by entecavir for hepatitis B prophylaxis, and finally by rituximab. This case of glomerulonephritis was notable for its resemblance to the better known Goodpasture’s disease. Typically, Goodpasture’s syndrome exists on a spectrum from seronegative disease to double-positive disease that presents with both anti–glomerular basement membrane (anti-GBM) and cytoplasmic-antineutrophil cytoplasmic antibodies/antiproteinase 3 antibodies (c-ANCA/anti-PR3). However, this patient’s glomerulonephritis was unique because he presented negative for anti-GBM antibodies and positive for perinuclear-antineutrophil cytoplasmic antibodies/antimyeloperoxidase antibodies (p-ANCA/anti-MPO).

Antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with anti-GBM crescentic glomerulonephritis

2005 ◽  
Vol 63 (06) ◽  
pp. 423-428 ◽  
Author(s):  
G. Yang ◽  
Z. Tang ◽  
Y. Chen ◽  
C. Zeng ◽  
H. Chen ◽  
...  
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Chinese Patients ◽  
Antineutrophil Cytoplasmic Antibodies

Takayasu's Arteritis Coexisting with Wegener's Granulomatosis in a Teenager with Renal Insufficiency: Case Report

1999 ◽  
Vol 2 (4) ◽  
pp. 385-388 ◽  
Author(s):  
Carmen Mejia-Hernandez ◽  
Antonio Alvarez-Mendoza ◽  
Beatriz DeLeon-Bojorge
Keyword(s):  
Renal Insufficiency ◽  
Elevated Level ◽  
Wegener’S Granulomatosis ◽  
Crescentic Glomerulonephritis ◽  
Takayasu’S Arteritis ◽  
Wegener's Granulomatosis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Infectious Agents ◽  
Takayasu's Arteritis ◽  
Severe Renal Insufficiency

A case of Wegener's granulomatosis (WG) coexisting with Takayasu's arteritis (TA) in a 12-year-old girl is presented. She presented with fulminant and severe renal insufficiency due to crescentic glomerulonephritis. At autopsy, aortic lesions of Takayasu's arteritis coexisted with pulmonary and renal findings of WG, and the patient's serum at autopsy had an elevated level of antineutrophil cytoplasmic antibodies (ANCA). Both forms of vasculitis have been thought to be triggered by infectious agents and it is postulated that this occurrence accounts for the coexistence of the two forms of vasculitis in this case.

scholarly journals Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis Associated with Multiple Myeloma

2015 ◽  
Vol 5 (2) ◽  
pp. 124-129 ◽  
Author(s):  
Cyriacus Uzoma Anaele ◽  
Weeraporn Srisung ◽  
Yvette Tomacruz ◽  
Melvin Laski
Keyword(s):  
Multiple Myeloma ◽  
Serum Protein ◽  
Crescentic Glomerulonephritis ◽  
Interstitial Fibrosis ◽  
Protein Electrophoresis ◽  
Serum Protein Electrophoresis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Normocytic Anemia ◽  
Tubular Atrophy ◽  
Cell Counts

Pauci-immune crescentic glomerulonephritis (PICGN) is most commonly associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of chronic, sclerosing ANCA-negative PICGN discovered when a patient presented with multiple myeloma. A 57-year-old woman presented with complaints of nausea, emesis and weakness. She was found to be in renal failure with a serum creatinine of 9.4 mg/dl, mild hyperkalemia and acidosis. She was noted to have normochromic, normocytic anemia with normal platelet and white cell counts, normal plasma proteins and serum protein electrophoresis. Further studies revealed increased concentrations of κ and λ light chains in a ratio of 34.89; a bone marrow biopsy found 12% plasma cells. Serum protein electrophoresis revealed no spike. ANCA, anti-glomerular basement membrane, antineutrophil antibody, hepatitis panel and serum complements were normal. A kidney biopsy result showed chronic sclerosing PICGN plus tubular necrosis, severe tubular atrophy, interstitial fibrosis and severe arteriosclerosis. Congo red stains were negative and electron microscopy showed no intraglomerular deposits. The patient was subsequently treated for myeloma with bortezomib and dexamethasone with good hematologic response but never recovered renal function. She remains on outpatient hemodialysis. Renal manifestations of myeloma often involve glomerular deposition disease, tubulointerstitial disease, with characteristic proteinaceous casts, or both. In contrast, our patient demonstrated neither of these findings but had chronic sclerosing PICGN. Crescentic glomerulonephritis occurring in patients with plasma cell dyscrasias has been previously reported, but the association remains extremely rare.

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