Antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with anti-GBM crescentic glomerulonephritis

2005 ◽  
Vol 63 (06) ◽  
pp. 423-428 ◽  
Author(s):  
G. Yang ◽  
Z. Tang ◽  
Y. Chen ◽  
C. Zeng ◽  
H. Chen ◽  
...  
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Chinese Patients ◽  
Antineutrophil Cytoplasmic Antibodies

scholarly journals Rare case of atypical crescentic glomerulonephritis and interstitial lung disease with negative anti-GBM antibody and positive anti-MPO antibody

2019 ◽  
Vol 12 (8) ◽  
pp. e229256 ◽  
Author(s):  
Alexander Hanna ◽  
Jenny Ross ◽  
Fernanda Heitor
Keyword(s):  
Hepatitis B ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Rare Case ◽  
Crescentic Glomerulonephritis ◽  
Kidney Biopsy ◽  
Flank Pain ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Hepatitis B Infection ◽  
Double Positive

A 70-year-old man presented with 1 month of haematuria and mild right-sided flank pain with no other symptoms. Diagnostic workup included serum studies which showed the presence of antimyeloperoxidase antibodies, a kidney biopsy which demonstrated necrotising crescentic glomerulonephritis with linear immunofluorescence of the basement membrane, and electron microscopy which exhibited thickening of the glomerular basement membrane. Incidentally, the patient was discovered to have a latent hepatitis B infection, which complicated immunosuppressive therapy. He was treated with a course of plasmapheresis and methylprednisolone, followed by entecavir for hepatitis B prophylaxis, and finally by rituximab. This case of glomerulonephritis was notable for its resemblance to the better known Goodpasture’s disease. Typically, Goodpasture’s syndrome exists on a spectrum from seronegative disease to double-positive disease that presents with both anti–glomerular basement membrane (anti-GBM) and cytoplasmic-antineutrophil cytoplasmic antibodies/antiproteinase 3 antibodies (c-ANCA/anti-PR3). However, this patient’s glomerulonephritis was unique because he presented negative for anti-GBM antibodies and positive for perinuclear-antineutrophil cytoplasmic antibodies/antimyeloperoxidase antibodies (p-ANCA/anti-MPO).

scholarly journals Detection Rate and Antigenic Specificities of Antineutrophil Cytoplasmic Antibodies in Chinese Patients with Clinically Suspected Vasculitis

2004 ◽  
Vol 11 (3) ◽  
pp. 559-562 ◽  
Author(s):  
Gang Xin ◽  
Ming-hui Zhao ◽  
Hai-yan Wang
Keyword(s):  
Detection Rate ◽  
Solid Phase ◽  
Cathepsin G ◽  
Chinese Patients ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Small Vessel Vasculitis ◽  
Antigen Specificity ◽  
Leukocyte Elastase ◽  
Female Ratio ◽  
Male Female Ratio

ABSTRACT The detection rate of antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with clinically suspected small vessel vasculitis was investigated, and their antigen specificity and demographic features were analyzed. A number of sera (n = 5,604) sent to our referral laboratory for ANCA screening were tested by indirect immunofluorescence (IIF), enzyme-linked immunosorbent assays (ELISAs) for myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA. Then the IIF-ANCA-positive sera that were negative for MPO- and PR3-ANCA were further tested by antigen-specific ELISA by using other five highly purified known ANCA antigens as solid-phase ligands. The known antigens included bactericidal/permeability-increasing protein (BPI), human leukocyte elastase (HLE), lactoferrin, cathepsin G, and azurocidins. Of the 5,604 sera, 267 (4.76%) sera were IIF-ANCA positive and 390 (7%) were antinuclear antibody (ANA) positive in the IIF assay. Of the IIF-positive samples, 213 were anti-MPO positive, 32 were anti-PR3 positive, and five cases were positive for both. Of the 48 sera positive for IIF-ANCA but negative for MPO- and PR3-ANCA, 13 sera (27%) recognized other target antigens, 7 sera recognized BPI, 5 recognized HLE, 1 recognize cathepsin G, and 1 recognized azurocidin. None of the sera recognized lactoferrin, and one serum sample recognized both BPI and HLE. The majority of ANCA-positive patients presented in summer or winter. There was no difference in gender (male/female ratio, 1:1.12) in ANCA-positive patients with a mean age of 53.1 years. The male/female ratio was 1.17:1 for patients over 60 years of age; however, it was 1:4 for patients under 20 years of age. We conclude that ANCA-related diseases are not rare in China, and the major antigens are MPO and PR3. When the IIF technique is used to detect ANCA, ANA should be carefully distinguished.

Takayasu's Arteritis Coexisting with Wegener's Granulomatosis in a Teenager with Renal Insufficiency: Case Report

1999 ◽  
Vol 2 (4) ◽  
pp. 385-388 ◽  
Author(s):  
Carmen Mejia-Hernandez ◽  
Antonio Alvarez-Mendoza ◽  
Beatriz DeLeon-Bojorge
Keyword(s):  
Renal Insufficiency ◽  
Elevated Level ◽  
Wegener’S Granulomatosis ◽  
Crescentic Glomerulonephritis ◽  
Takayasu’S Arteritis ◽  
Wegener's Granulomatosis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Infectious Agents ◽  
Takayasu's Arteritis ◽  
Severe Renal Insufficiency

A case of Wegener's granulomatosis (WG) coexisting with Takayasu's arteritis (TA) in a 12-year-old girl is presented. She presented with fulminant and severe renal insufficiency due to crescentic glomerulonephritis. At autopsy, aortic lesions of Takayasu's arteritis coexisted with pulmonary and renal findings of WG, and the patient's serum at autopsy had an elevated level of antineutrophil cytoplasmic antibodies (ANCA). Both forms of vasculitis have been thought to be triggered by infectious agents and it is postulated that this occurrence accounts for the coexistence of the two forms of vasculitis in this case.

The clinical and pathological characteristics of Chinese patients with pauci‐immune crescentic glomerulonephritis

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. 155-159
Author(s):  
Zheng Tang ◽  
Yan Wu ◽  
Xiao‐Dan Yao ◽  
Wei‐Xin Hu ◽  
Hui‐Ping Chen ◽  
...  
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Chinese Patients ◽  
Pathological Characteristics

scholarly journals Antineutrophil cytoplasmic antibodies in Chinese patients with tuberculosis

2018 ◽  
Vol 51 (4) ◽  
pp. 475-478 ◽  
Author(s):  
Gao Huan ◽  
Gao Yang ◽  
Qu Xiao-yu ◽  
Xu Jiancheng ◽  
Song Yan-qing
Keyword(s):  
Chinese Patients ◽  
Antineutrophil Cytoplasmic Antibodies
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