Gamma-Aminobutyric Acid and Dysregulation of TSH Secretion in Uremic Male Rats

Nephron ◽  
1987 ◽  
Vol 46 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Alan N. Elias ◽  
Nosratola D. Vaziri ◽  
M.R. Pandian ◽  
Krish Iyer ◽  
Mohammad A. Ansari
Keyword(s):  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Tsh Secretion

scholarly journals Chemogenetic activation of mesoaccumbal Gamma-Aminobutyric Acid projections selectively tunes responses to predictive cues when reward value is abruptly decreased

2020 ◽  
Author(s):  
Ken T. Wakabayashi ◽  
Malte Feja ◽  
Martin P.K. Leigh ◽  
Ajay N. Baindur ◽  
Mauricio Suarez ◽  
...  
Keyword(s):  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Inhibitory Circuits ◽  
Gaba Neurons ◽  
Reward Seeking ◽  
Reward Value ◽  
Seeking Behavior ◽  
Adaptive Responding ◽  
Viral Targeting

ABSTRACTBackgroundMesolimbic circuits regulate the attribution of motivational significance to incentive cues that predict reward, yet this network also plays a key role in adapting reward-seeking behavior when the contingencies linked to a cue unexpectedly change. Here we asked whether mesoaccumbal gamma-aminobutyric acid (GABA) projections enhance adaptive responding to incentive cues of abruptly altered reward value, and whether these effects were distinct from global activation of all ventral tegmental area (VTA) GABA circuits.MethodsWe used a viral targeting system to chemogenetically activate mesoaccumbal GABA projections in male rats during a novel cue-dependent operant Value Shifting (VS) task, in which the volume of a sucrose reward associated with a predictive cue is suddenly altered, from the beginning and throughout the session. We compared the results with global activation of VTA GABA neurons, which will activate local inhibitory circuits and long loop projections.ResultsWe found that activation of mesoaccumbal GABA projections decreases responding to incentive cues associated with smaller-than-expected rewards. This tuning of behavioral responses was specific to cues associated with smaller-than-expected rewards, but did not impact measures related to consuming the reward. In marked contrast, activating all VTA(GABA) neurons resulted in a uniform decrease in responding to incentive cues irrespective of changes in the size of the reward.ConclusionsTargeted activation of mesoaccumbal GABA neurons facilitate adaptation in reward-seeking behaviors. This suggests that these projections may play a very specific role in associative learning processes.

Probable gamma-aminobutyric acid involvement in bisphenol A effect at the hypothalamic level in adult male rats

2011 ◽  
Vol 67 (4) ◽  
pp. 559-567 ◽  
Author(s):  
Nancy Cardoso ◽  
Matías Pandolfi ◽  
Justina Lavalle ◽  
Silvia Carbone ◽  
Osvaldo Ponzo ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Hypothalamic Level

CHANGES IN SERUM TSH LEVEL AFTER INTRAVENTRICULAR INJECTION OF VARIOUS NEUROMEDIATORS IN RATS

1978 ◽  
Vol 87 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Henryk Holak ◽  
Agata Baldys ◽  
Barbara Jarzab ◽  
Antoni Wystrychowski ◽  
Jan Skrzypek
Keyword(s):  
Lateral Ventricle ◽  
Aminobutyric Acid ◽  
Intraventricular Injection ◽  
Control Group ◽  
Gamma Aminobutyric Acid ◽  
Control Groups ◽  
Tsh Secretion ◽  
Surgical Manipulations ◽  
The Brain ◽  
Serum Tsh

ABSTRACT The influence of various neuromediators on pituitary TSH secretion in rats has been investigated. Noradrenaline 50 μg/rat, dopamine 50 μg/rat, serotonine-creatinine-sulphate 100 μg/rat, gamma-aminobutyric acid 100 μg/rat, pilocarpine 1 mg/rat, histamine 100 μ/rat were administered into the lateral ventricle of the brain. All agents were dissolved in Parker's fluid. Two control groups of animals were given Parker's fluid and subjected to surgical manipulations, respectively. Plasma TSH level was estimated after 30 min by means of radioimmunoassay. The increase in the TSH level was observed after the injection of serotonine and noradrenaline (4.0 and 3.1 ng/ml, respectively) as compared with control group (0.7 ng/ml).

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

Sign in / Sign up

Export Citation Format

Share Document